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Open-Label Extension (OLE) Study to Assess Safety, Efficacy, and Tolerability of Lorundrostat in Subjects With Hypertension
Sponsor: Mineralys Therapeutics Inc.
Summary
This study is to evaluate the long-term safety, efficacy and tolerability of lorundrostat (an aldosterone synthase inhibitor) in subjects with hypertension
Official title: An Open-Label Extension Study to Assess the Long-Term Safety, Efficacy, and Tolerability of Lorundrostat in Subjects With Hypertension
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1076
Start Date
2023-07-14
Completion Date
2027-05
Last Updated
2026-11-04
Healthy Volunteers
No
Conditions
Interventions
lorundrostat
Tablet, administered orally
Placebo
Tablet, administered orally
Locations (177)
Accel Research Sites (ARS) - Birmingham Clinical Research Unit
Birmingham, Alabama, United States
G & L Research LLC
Foley, Alabama, United States
Chandler Clinical Trials
Chandler, Arizona, United States
Arizona Kidney
Glendale, Arizona, United States
AKDHC Medical Research Services, AZ
Phoenix, Arizona, United States
Noble Clinical Research
Tucson, Arizona, United States
Del Sol Research Management, LLC
Tucson, Arizona, United States
Entertainment Medical Group, Inc
Beverly Hills, California, United States
CA Institute of Renal Research, CA
Chula Vista, California, United States
Amicis Research Center - Vacaville
Fairfield, California, United States
Amicis Research Center - Granada Hills
Granada Hills, California, United States
Marvel Clinical Research 002, LLC
Huntington Beach, California, United States
University of California San Diego (UCSD) - Altman Clinical and Translational Research Institute (ACTRI)
La Jolla, California, United States
Clinical Trials Research (CTR) - Lincoln
Lincoln, California, United States
Academic Medical Research Institute (AMRI) - Los Angeles
Los Angeles, California, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
Amicis Research Center - Mission Hills
Northridge, California, United States
Amicis Research Center-Northridge
Northridge, California, United States
Northridge Clinical Trials
Northridge, California, United States
Pasadena Clinical Trials
Pasadena, California, United States
Empire Clinical Research
Pomona, California, United States
Clinical Trials Research (CTR) - Sacramento
Sacramento, California, United States
Triwest Research Associates
San Diego, California, United States
San Jose Clinical Trials
San Jose, California, United States
Amicis Research Center - Valencia
Valencia, California, United States
Kidney & Hypertension Center - Victorville
Victorville, California, United States
Blue Coast Research Center (BCRC)
Vista, California, United States
Accelerated Enrollment Solutions (AES) -Vista/Synexus (Radiant Research)
Vista, California, United States
Colorado Kidney (Denver) Nephrology
Denver, Colorado, United States
CMR of Greater New Haven
Hamden, Connecticut, United States
Qway Research
Hialeah, Florida, United States
Indago Research and Health Center
Hialeah, Florida, United States
Clinical Neuroscience Solutions, Inc
Jacksonville, Florida, United States
Nuovida Research Center Corp
Miami, Florida, United States
Clinical Neuroscience Solutions, Inc
Orlando, Florida, United States
Nephrology Associates of Central Florida
Orlando, Florida, United States
AES - Orlando
Orlando, Florida, United States
Pines Care Research Center
Pembroke Pines, Florida, United States
Patron Medical - Andres Patron D.O. (Patron Ventures, LLC)
Pembroke Pines, Florida, United States
Progressive Medical Research
Port Orange, Florida, United States
Infigo Clinical Research (Mid Florida)
Sanford, Florida, United States
Clinical Research of West Florida, Inc.
Tampa, Florida, United States
AES The Villages
The Villages, Florida, United States
Palm Beach Diabetes and Endocrine Specialists, PA (PBDES) - West Palm Beach Office)
West Palm Beach, Florida, United States
American Clinical Trials
Acworth, Georgia, United States
Morehouse School of Medicine
Atlanta, Georgia, United States
Coastal Medical
Brunswick, Georgia, United States
Accel Research Sites
Decatur, Georgia, United States
Georgia Clinical Research, LLC
Lawrenceville, Georgia, United States
Alta Pharmaceutical Research Center
Peachtree Corners, Georgia, United States
Elite Clinical Trials
Blackfoot, Idaho, United States
Meridian Family Medicine
Meridian, Idaho, United States
AES Chicago/Synexus Clinical Research
Chicago, Illinois, United States
Eagle Clinical Research
Chicago, Illinois, United States
The University of Chicago Medicine
Chicago, Illinois, United States
Healthcare Research Network - Chicago
Flossmoor, Illinois, United States
Koch Family Medicine, S.C
Morton, Illinois, United States
Southern Illinois School of Medicine
Springfield, Illinois, United States
Hendricks Regional Health Medical Group - Lizton Family Medicine
Brownsburg, Indiana, United States
AES Evansville/Synexus Clinical Research
Evansville, Indiana, United States
ASHA Clinical Research- Munster, LLC
Hammond, Indiana, United States
The Research Group of Lexington, LLC
Lexington, Kentucky, United States
Nephrology Associates of Kentuckiana
Louisville, Kentucky, United States
Alliance for Multispecialty Research, LLC
New Orleans, Louisiana, United States
Northwest Louisiana Nephrology, LLC - Shreveport
Shreveport, Louisiana, United States
Boston Clinical Trials
Boston, Massachusetts, United States
ActiveMed Practices & Research LLC
Methuen, Massachusetts, United States
Hattiesburg Clinic
Petal, Mississippi, United States
Healthcare Research Network-Hazelwood
Hazelwood, Missouri, United States
Clinical Research Consultants (CRC) - Kansas City
Kansas City, Missouri, United States
Quality Clinical Research
Omaha, Nebraska, United States
Henderson Clinical Trials
Henderson, Nevada, United States
Synexus Clinical Research US, Inc.
Henderson, Nevada, United States
Sierra Clinical Research
Las Vegas, Nevada, United States
Oasis Clinical Trials
Las Vegas, Nevada, United States
Las Vegas Clinical Trials
North Las Vegas, Nevada, United States
Renown Regional Medical Center
Reno, Nevada, United States
Albany Medical College
Albany, New York, United States
Erie County Medical Center
Buffalo, New York, United States
AES New York/Synexus Clinical Research
New York, New York, United States
Columbia University
New York, New York, United States
Triad Internal Medicine
Asheboro, North Carolina, United States
East Carolina University (ECU) Physicians - East Carolina Heart Institute - East Carolina University Location
Greenville, North Carolina, United States
Physician's East Endocrinology
Greenville, North Carolina, United States
Carteret Medical Group
Morehead City, North Carolina, United States
Centricity Research New Bern Multispecialty
New Bern, North Carolina, United States
Research Innovations (Elligo Health Research)
Beavercreek, Ohio, United States
Diabetes & Endocrinology Associates of Stark County
Canton, Ohio, United States
Intrepid Research
Cincinnati, Ohio, United States
Cleveland Clinic - Main Campus
Cleveland, Ohio, United States
Arthritis & Osteoarthritis Center of SW Ohio/ dba STAT Research
Vandalia, Ohio, United States
Lynn Institute of Norman (LION Research)
Norman, Oklahoma, United States
Willamette Valley Clinical Studies
Eugene, Oregon, United States
AMS Cardiology (Elligo)
Horsham, Pennsylvania, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Preferred Primary Care Physicians
Pittsburgh, Pennsylvania, United States
Accelerated Enrollment Solutions (AES) - Anderson
Anderson, South Carolina, United States
Wake Research - Notus Clinical Trials, LLC
Charleston, South Carolina, United States
Coastal Carolina Research Center
North Charleston, South Carolina, United States
Chattanooga Medical Research
Chattanooga, Tennessee, United States