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A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.
Sponsor: AstraZeneca
Summary
The purpose of eVOLVE-Lung02 is to test the effectiveness (efficacy) and measure the safety of volrustomig in combination with chemotherapy compared with pembrolizumab in combination with chemotherapy as 1L treatment in participants with mNSCLC in PD-L1 \< 50%.
Official title: A Phase III, Two-Arm, Parallel, Randomized, Multi-Center, Open-Label, Global Study to Determine the Efficacy of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for First-Line Treatment of Patients With Metastatic Non-Small Cell Lung Cancer (mNSCLC).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
895
Start Date
2023-10-24
Completion Date
2027-11-12
Last Updated
2026-10-09
Healthy Volunteers
No
Conditions
Interventions
Volrustomig
Volrustomig
Pembrolizumab
Pembrolizumab
Carboplatin
Carboplatin
Paclitaxel
Paclitaxel
Pemetrexed
Pemetrexed
Locations (231)
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Hot Springs, Arkansas, United States
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Springdale, Arkansas, United States
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Long Beach, California, United States
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Lone Tree, Colorado, United States
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Orlando, Florida, United States
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St. Petersburg, Florida, United States
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Indianapolis, Indiana, United States
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Des Moines, Iowa, United States
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Baltimore, Maryland, United States
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Towson, Maryland, United States
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Detroit, Michigan, United States
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Grand Island, Nebraska, United States
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Lincoln, Nebraska, United States
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Omaha, Nebraska, United States
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East Syracuse, New York, United States
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Columbus, Ohio, United States
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Portland, Oregon, United States
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Horsham, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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Memphis, Tennessee, United States
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Nashville, Tennessee, United States
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Nashville, Tennessee, United States
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Houston, Texas, United States
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Irving, Texas, United States
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Fairfax, Virginia, United States
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Tacoma, Washington, United States
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CABA, Argentina
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CABA, Argentina
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CABA, Argentina
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Córdoba, Argentina
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Córdoba, Argentina
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La Plata, Argentina
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La Plata, Argentina
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Rosario, Argentina
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Clayton, Australia
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Fitzroy, Australia
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Heidelberg, Australia
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South Brisbane, Australia
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Sydney, Australia
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Linz, Austria
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Wels, Austria
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Aalst, Belgium
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Antwerp, Belgium
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Ghent, Belgium
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Barretos, Brazil
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Curitiba, Brazil
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Florianópolis, Brazil
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Fortaleza, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Rio de Janeiro, Brazil
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Santa Cruz do Sul, Brazil
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São Paulo, Brazil
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Calgary, Alberta, Canada
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Edmonton, Alberta, Canada
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Winnipeg, Manitoba, Canada
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Halifax, Nova Scotia, Canada
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Barrie, Ontario, Canada
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Oshawa, Ontario, Canada
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Toronto, Ontario, Canada
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Lévis, Quebec, Canada
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Trois-Rivières, Quebec, Canada
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Chicoutimi, Canada
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Beijing, China
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Beijing, China
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Changchun, China
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Changsha, China
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Chengdu, China
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Chengdu, China
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Chongqing, China
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Fuzhou, China
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Guangzhou, China
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Hangzhou, China
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Hangzhou, China
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Lanzhou, China
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Nanchang, China
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Nanchang, China
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Nanjing, China
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Nanning, China
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Shanghai, China
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Shanghai, China
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Shanghai, China
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Shenzhen, China
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Taiyuan, China
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Tianjin, China
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Wuhan, China
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Wuhan, China
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Wuhan, China
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Xi'an, China
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Yangzhou, China
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Zhengzhou, China
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Olomouc, Czechia
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Ostrava - Vitkovice, Czechia
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Prague, Czechia
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Angers, France
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Avignon, France
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Bayonne, France
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Bordeaux, France
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Caen, France