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RECRUITING

NCT06008197

PHASE3

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

Sponsor: Colorado Prevention Center

View on ClinicalTrials.gov

Summary

Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricular ejection fraction.

Official title: Randomized Trial to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Heart Failure Patients With Left Ventricular Ejection Fraction Greater Than or Equal to 40% Hospitalized Due to an Episode of Acute Decompensated Heart Failure (REDEFINE-HF)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

5200

Start Date

2024-01-17

Completion Date

2027-12

Last Updated

2026-09-10

Healthy Volunteers

Conditions

Heart Failure Acute Heart Failure

Interventions

DRUG

Finerenone

Oral finerenone

DRUG

Placebo

Matching oral placebo

Locations (356)

Birmingham, AL Investigative Site 10012

Birmingham, Alabama, United States

Fairhope, AL Investigative Site 10004

Fairhope, Alabama, United States

Huntsville, AL Investigative Site 10026

Huntsville, Alabama, United States

Glendale, AZ Investigative Site 10096

Glendale, Arizona, United States

Phoenix, AZ Investigative Site 10115

Phoenix, Arizona, United States

Scottsdale, AZ Investigative Site 10003

Scottsdale, Arizona, United States

Chula Vista, CA Investigative Site 10111

Chula Vista, California, United States

Huntington Beach, CA Investigative Site 10031

Huntington Beach, California, United States

Los Angeles, CA Investigative Site 10089

Los Angeles, California, United States

Sacramento, CA Investigative Site 10024

Sacramento, California, United States

San Francisco, CA Investigative Site 10023

San Francisco, California, United States

Tarzana, CA Investigative Site 10409

Tarzana, California, United States

Van Nuys, CA Investigative Site 10109

Van Nuys, California, United States

West Hills, CA Investigative Site 10013

West Hills, California, United States

Aurora, CO Investigative Site 10001

Aurora, Colorado, United States

Denver, CO Investigative Site 10005

Denver, Colorado, United States

Bradenton, FL Investigative Site 10125

Bradenton, Florida, United States

Brooksville, FL Investigative Site 10077

Brooksville, Florida, United States

Fort Lauderdale, FL Investigative Site 10114

Fort Lauderdale, Florida, United States

Fort Myers, FL Investigative Site 10076

Fort Myers, Florida, United States

Hialeah, FL Investigative Site 10104

Hialeah, Florida, United States

Jacksonville, FL Investigative Site 10028

Jacksonville, Florida, United States

Miami, FL Investigative Site 10105

Miami, Florida, United States

Miami, FL Investigative Site 10040

Miami, Florida, United States

Miramar, FL Investigative Site 10113

Miramar, Florida, United States

Tamarac, Florida Investigative Site 10127

Tamarac, Florida, United States

Atlanta, GA Investigative Site 10022

Atlanta, Georgia, United States

Duluth, GA Investigative Site 10083

Duluth, Georgia, United States

Boise, Idaho Investigative Site 10073

Boise, Idaho, United States

Chicago, IL Investigative Site 10062

Chicago, Illinois, United States

Glenview, IL Investigative Site 10021

Glenview, Illinois, United States

Naperville, IL Investigative Site 10025

Naperville, Illinois, United States

Peoria, IL Investigative Site 10019

Peoria, Illinois, United States

Peoria, IL Investigative Site 10010

Peoria, Illinois, United States

Indianapolis, IN Investigative Site 10074

Indianapolis, Indiana, United States

Indianapolis, IN Investigative Site 10008

Indianapolis, Indiana, United States

Merrillville, IN Investigative Site 10064

Merrillville, Indiana, United States

Kansas City, KS Investigative Site 10060

Kansas City, Kansas, United States

Cynthiana, KY Investigative Site 10124

Cynthiana, Kentucky, United States

Lexington, KY Investigative Site 10080

Lexington, Kentucky, United States

Lexington, KY Investigative Site 10118

Lexington, Kentucky, United States

Louisville, KY Investigative Site 10006

Louisville, Kentucky, United States

Louisville, KY Investigative Site 10086

Louisville, Kentucky, United States

Paducah, KY Investigative Site 10079

Paducah, Kentucky, United States

Baton Rouge, LA Investigative Site 10030

Baton Rouge, Louisiana, United States

Hammond, LA Investigative Site 10106

Hammond, Louisiana, United States

West Monroe, LA Investigative Site 10090

West Monroe, Louisiana, United States

Baltimore, MD Investigative Site 10101

Baltimore, Maryland, United States

Bowie, MD Investigative Site 10020

Bowie, Maryland, United States

Boston, MA Investigative Stie 10087

Boston, Massachusetts, United States

Minneapolis, MN Investigative Site 10091

Minneapolis, Minnesota, United States

Minneapolis, MN Investigative Site 10035

Minneapolis, Minnesota, United States

Tupelo, MS Investigative Site 10100

Tupelo, Mississippi, United States

Kansas City, MO Investigative Site 10002

Kansas City, Missouri, United States

Omaha, NE Investigative Site 10018

Omaha, Nebraska, United States

Camden, NJ Investigative Site 10033

Camden, New Jersey, United States

Roslyn, NY Investigative Site 10058

Roslyn, New York, United States

Stony Brook, NY Investigative Site 10017

Stony Brook, New York, United States

Greenville, NC Investigative Site 10122

Greenville, North Carolina, United States

Akron, OH Investigative Site 10081

Akron, Ohio, United States

Centerville, OH Investigative Site 10119

Centerville, Ohio, United States

Cincinnati, OH Investigative Site 10088

Cincinnati, Ohio, United States

Bartlesville, OK Investigative Site 10095

Bartlesville, Oklahoma, United States

Philadelphia, PA Investigative Site 10068

Philadelphia, Pennsylvania, United States

Pittsburg, PA Investigative Site 1044

Pittsburgh, Pennsylvania, United States

Providence, RI Investigative Site 10050

Providence, Rhode Island, United States

Charleston, SC Investigative Site 10056

Charleston, South Carolina, United States

Germantown, TN Investigative Site 10063

Germantown, Tennessee, United States

Memphis, TN Investigative Site 10059

Memphis, Tennessee, United States

Nashville, TN Investigative Site 10071

Nashville, Tennessee, United States

Amarillo, TX Investigative Site 10045

Amarillo, Texas, United States

Austin, TX Investigative Site 10015

Austin, Texas, United States

Dallas, TX Investigative Site 10042

Dallas, Texas, United States

Houston, TX Investigative Site 10085

Houston, Texas, United States

Plano, TX Investigative Site 10014

Plano, Texas, United States

Burlington, VT Investigative Site 10053

Burlington, Vermont, United States

Norfolk, VA Investigative Site 10009

Norfolk, Virginia, United States

Richmond, VA Investigative Site 10069

Richmond, Virginia, United States

Richmond, VA Investigative Site 10067

Richmond, Virginia, United States

Salem, VA Investigative Site 10048

Salem, Virginia, United States

Spokane, WA Investigative Site 10123

Spokane, Washington, United States

Milwaukee, WI Investigative Site 10061

Milwaukee, Wisconsin, United States

Buenos Aires Investigative Site 20017

Buenos Aires, Buenos Aires, Argentina

Buenos Aires Investigative Site 20009

Buenos Aires, Buenos Aires, Argentina

La Plata, Buenos Aires Investigative Site 20023

La Plata, Buenos Aires, Argentina

Lanús, Buenos Aires Investigative Site 20024

Lanus, Buenos Aires, Argentina

Corrientes Investigative Site 20001

Corrientes, Corrientes Province, Argentina

Córdoba Investigative Site 20025