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RECRUITING

NCT06033950

PHASE3

A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists

Sponsor: Colorado Prevention Center

View on ClinicalTrials.gov

Summary

Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients with heart failure and reduced ejection fraction (HFrEF) who are intolerant or ineligible to receive treatment with steroidal mineralocorticoid receptor antagonists (sMRA).

Official title: A Randomized, Double-blind, Placebo-controlled Pragmatic Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure and Reduced Ejection Fraction Who Are Intolerant of or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists (FINALITY-HF)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

2600

Start Date

2024-08-20

Completion Date

2028-01

Last Updated

2026-07-10

Healthy Volunteers

Conditions

Heart Failure

Interventions

DRUG

Finerenone

Oral finerenone.

DRUG

Placebo

Matching oral placebo.

Locations (176)

FIN-10004 Fairhope, AL Investigational Site

Fairhope, Alabama, United States

Phoenix, AZ Investigative Site FIN-10115

Phoenix, Arizona, United States

FIN-10401, Yuma, AZ

Yuma, Arizona, United States

Chula Vista, CA Investigative Site FIN-10419

Chula Vista, California, United States

Chula Vista, CA Investigative Site FIN-10111

Chula Vista, California, United States

FIN-10407, Northridge, CA

Northridge, California, United States

FIN-10412, Orange, CA

Orange, California, United States

FIN-10070, Pamona, CA

Pomona, California, United States

FIN-10024, Sacramento, CA

Sacramento, California, United States

FIN-10406, San Diego, CA

San Diego, California, United States

San Diego, CA Investigative Site FIN-10420

San Diego, California, United States

FIN-10075 San Diego, CA Investigational Site

San Diego, California, United States

San Francisco, CA Investigative Site FIN-10023

San Francisco, California, United States

FIN-10423, Sherman Oaks, CA

Sherman Oaks, California, United States

FON-10409, Tarzana, CA

Tarzana, California, United States

FIN-10109, Van Nuys, CA

Van Nuys, California, United States

FIN-10408, West Covina, CA

West Covina, California, United States

FIN-10013, West Hills, CA

West Hills, California, United States

FIN-10110, Aurora, CO

Aurora, Colorado, United States

FIN-10001, Aurora, CO

Aurora, Colorado, United States

Bradenton, FL Investigative Site FIN-10125

Bradenton, Florida, United States

FIN-10104, Hialeah, FL

Hialeah, Florida, United States

FIN-10028, Jacksonville, FL

Jacksonville, Florida, United States

FIN-10105, Miami, FL

Miami, Florida, United States

FIN-10113, Miramar, FL

Miramar, Florida, United States

FIN-10019, Peoria, IL

Peoria, Illinois, United States

FIN-10064, Merrillville, IN

Merrillville, Indiana, United States

Cynthiana, KY Investigative Site FIN-10124

Cynthiana, Kentucky, United States

FIN-10080, Lexington, KY

Lexington, Kentucky, United States

Lexington, KY Investigative Site FIN-10118

Lexington, Kentucky, United States

FIN-10086, Louisville, KY

Louisville, Kentucky, United States

Louisville, KY Investigative Site FIN-10417

Louisville, Kentucky, United States

FIN-10079, Paducah, KY

Paducah, Kentucky, United States

FIN-10030, Baton Rouge, LA

Baton Rouge, Louisiana, United States

FIN-10106, Hammond, LA

Hammond, Louisiana, United States

FIN-10090, West Monroe, LA

West Monroe, Louisiana, United States

Minneapolis, MN Investigative Site FIN-10035

Minneapolis, Minnesota, United States

FIN-10002 Kansas City, MO Investigational Site

Kansas City, Missouri, United States

FIN-10318, Charlotte, NC

Charlotte, North Carolina, United States

Greenville, NC Investigative Site FIN-10122

Greenville, North Carolina, United States

FIN-10081, Akron, OH

Akron, Ohio, United States

FIN-10119, Centerville, OH

Centerville, Ohio, United States

FIN- 10112, Cincinnati, OH

Cincinnati, Ohio, United States

Orangeburg, SC Investigative Site FIN-10433

Orangeburg, South Carolina, United States

FIN-10015 Austin, TX Investigational Site

Austin, Texas, United States

FIN-10404, Denison, TX

Denison, Texas, United States

FIN-10085, Houston, TX

Houston, Texas, United States

Tyler, TX Investigative Site FIN-10422

Tyler, Texas, United States

FIN-10405, Layton, UT

Layton, Utah, United States

FIN-10053, Burlington, VT

Burlington, Vermont, United States

FIN-10402, Norfolk, VA

Norfolk, Virginia, United States

FIN-10093, Richmond, VA

Richmond, Virginia, United States

Salem, VA Investigative Site FIN-10048

Salem, Virginia, United States

Milwaukee, WI Investigative Site FIN-10428

Milwaukee, Wisconsin, United States

Lanus, Buenos Aires Investigative Site FIN-20024

Lanus, Buenos Aires, Argentina

Rosario, Santa Fe Investigative Site FIN-20022

Rosario, Santa Fe Province, Argentina

Buenos Aires Investigative Site FIN-20031

Buenos Aires, Argentina

Córdoba Investigative Site FIN-20025

Córdoba, Argentina

Córdoba Investigative Site FIN-20030

Córdoba, Argentina

San Juan, San Juan Investigative Site FIN-20020

San Juan, Argentina

San Juan, San Juan Investigative Site FIN-20021

San Juan, Argentina

FIN-21063, Rio Branco, Acre

Rio Branco, Acre, Brazil

FIN-21078, Maceió, Alagoas

Maceió, Alagoas, Brazil

FIN-21072 Salvador, Bahia - BA

Salvador, Bahia - BA, Brazil

Fortaleza, Ceará Investigative Site'FIN-21076

Fortaleza, Ceará, Brazil

Fortaleza, Ceará Investigative Site FIN-21055

Fortaleza, Ceará, Brazil

FIN-21032, Salvador, Bahia

Salvador, Estado de Bahia, Brazil

FIN-21028, Brasilia, Distrito Federal

Brasília, Federal District, Brazil

FIN-21053, Aparecida de Goiânia, Goiás

Aparecida de Goiânia, Goiás, Brazil

FIN-21003 Goiania, Goias Investigational Site

Goiânia, Goiás, Brazil

Belo Horizonte, Minas Gerais