Clinical Research Directory
Browse clinical research sites, groups, and studies.
An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma
Sponsor: Hoffmann-La Roche
Summary
The purpose of this study is to compare the efficacy and safety of glofitamab in combination with polatuzumab vedotin plus rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) vs Pola-R-CHP in participants with previously untreated CD20-positive large B-cell lymphoma (LBCL).
Official title: A Phase III, Multicenter, Randomized, Open-Label Study Comparing the Efficacy and Safety of Glofitamab (RO7082859) in Combination With Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (Pola-R-CHP) Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
1130
Start Date
2023-09-18
Completion Date
2030-10-30
Last Updated
2026-09-11
Healthy Volunteers
No
Conditions
Interventions
Glofitamab
Participants will receive intravenous (IV) glofitamab
Polatuzumab vedotin
Participants will receive IV polatuzumab vedotin in combination with R-CHP
Rituximab
Participants will receive IV rituximab
Cyclophosphamide
Participants will receive cyclophosphamide as part of CHP chemotherapy
Doxorubicin
Participants will receive IV doxorubicin
Prednisone
Participants will receive oral prednisone as part of CHP chemotherapy
Locations (229)
Alaska Oncology & Hematology, LLC
Anchorage, Alaska, United States
Kaiser Permanente - Anaheim (E. La Palma)
Anaheim, California, United States
University of California, San Francisco-Fresno
Clovis, California, United States
City of Hope National Medical Center
Duarte, California, United States
City of Hope - Lennar Foundation Cancer Center
Irvine, California, United States
Valkyrie Clinical Trials
Los Angeles, California, United States
UCLA Jonsson Comprehensive Cancer Center
Los Angeles, California, United States
Kaiser Permanente - Roseville
Roseville, California, United States
Kaiser Permanente - Santa Clara
Santa Clara, California, United States
Stanford Univ School of Med
Stanford, California, United States
Kaiser Permanente Medical Ctr
Vallejo, California, United States
University of Colorado Cancer Center
Aurora, Colorado, United States
Rocky Mountain Cancer Center - Denver
Littleton, Colorado, United States
Yale University School Of Medicine
New Haven, Connecticut, United States
Medstar Franklin Square Medical Center
Washington D.C., District of Columbia, United States
Miami Cancer Institute of Baptist Health, Inc.
Miami, Florida, United States
Memorial Cancer Institute at Memorial West
Pembroke Pines, Florida, United States
Hawaii Cancer Care
Honolulu, Hawaii, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Chicago, Illinois, United States
Illinois Cancer Care
Peoria, Illinois, United States
Springfield Clinic
Springfield, Illinois, United States
University of Iowa
Iowa City, Iowa, United States
Ascension Via Christi Research
Wichita, Kansas, United States
Ochsner Medical Center
New Orleans, Louisiana, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Dana Farber Cancer Institute
Boston, Massachusetts, United States
Boston Medical Center
Boston, Massachusetts, United States
Henry Ford Health System
Novi, Michigan, United States
M Health Fairview University of Minnesota Medical Center
Minneapolis, Minnesota, United States
St. Luke's Hospital
Chesterfield, Missouri, United States
Washington University School of Medicine
St Louis, Missouri, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
NYU Langone Hospital?Brooklyn
Brooklyn, New York, United States
NYU Long Island Hospital
Mineola, New York, United States
New York University Medical Center PRIME
New York, New York, United States
Memorial Sloan Kettering Cancer Center David H Koch Center for Cancer Care
New York, New York, United States
Weill Cornell Medical College-New York Presbyterian Hospital
New York, New York, United States
University of Rochester Medical Center
Rochester, New York, United States
North Shore Hematology Oncology Association PC
Shirley, New York, United States
Montefiore Medical Center
The Bronx, New York, United States
New York Cancer & Blood Specialists
The Bronx, New York, United States
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Levine Cancer Institute
Charlotte, North Carolina, United States
Willamette Valley Cancer Insitute and Research Center
Springfield, Oregon, United States
Kimmel Cancer Center Thomas Jefferson University
Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States
West Penn Hospital
Pittsburgh, Pennsylvania, United States
Avera Cancer Institute
Sioux Falls, South Dakota, United States
Greco-Hainesworth Tennessee Oncology Centers for Research
Chattanooga, Tennessee, United States
West Cancer Center & Research Institute
Germantown, Tennessee, United States
Tennessee Oncology
Nashville, Tennessee, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center
Dallas, Texas, United States
USOR - Texas Oncology - San Antonio Northeast
San Antonio, Texas, United States
University of Vermont
Burlington, Vermont, United States
Virginia Cancer Specialists
Fairfax, Virginia, United States
Virginia Oncology Associates
Newport News, Virginia, United States
Swedish Medical Center
Seattle, Washington, United States
University of Washington - Seattle Cancer Care Alliance
Seattle, Washington, United States
West Virginia University
Morgantown, West Virginia, United States
Univ of Wisconsin Hosp & Clin
Madison, Wisconsin, United States
Instituto Alexander Fleming
Buenos Aires, Argentina
FUNDALEU
Buenos Aires, Argentina
Hospital Aleman de Buenos Aires
Buenos Aires, Argentina
Sanatorio Allende
Córdoba, Argentina
Concord Repatriation General Hospital
Concord, New South Wales, Australia
Prince of Wales Hospital- Department of Hematology
Randwick, New South Wales, Australia
Townsville Hospital
Douglas, Queensland, Australia
Princess Alexandra Hospital Woolloongabba
Woolloongabba, Queensland, Australia
Flinders Medical Centre
Bedford Park, South Australia, Australia
Royal Hobart Hospital
Hobart, Tasmania, Australia
Eastern Health
Box Hill, Victoria, Australia
St Vincent's Hospital Melbourne
Fitzroy, Victoria, Australia
Barwon Health
Geelong, Victoria, Australia
Peter Maccallum Cancer Centre
Melbourne, Victoria, Australia
Sir Charles Gairdner Hospital
Nedlands, Western Australia, Australia
Institut Jules Bordet
Anderlecht, Belgium
UZ Brussel
Brussels, Belgium
AZ Groeninge
Kortrijk, Belgium
CHU de Liège (Sart Tilman)
Liège, Belgium
Hospital Erasto Gaertner
Curitiba, Paraná, Brazil
Instituto D'Or Pesquisa e Ensino
São Paulo, São Paulo, Brazil
Hospital das Clinicas - FMUSP, Oncologia
São Paulo, São Paulo, Brazil
Queen Elizabeth II Health Sciences Centre
Halifax, Nova Scotia, Canada
William Osler Health Centre - Brampton Civic Hospital
Brampton, Ontario, Canada
Health Sciences North
Greater Sudbury, Ontario, Canada
Centre Hospitalier de l'Universite de Montreal (CHUM)
Montreal, Quebec, Canada
CHA Hopital de I enfant-Jesus
Québec, Quebec, Canada
Beijing Cancer Hospital
Beijing, China
Peking University Third Hospital
Beijing, China
The First Hospital of Jilin University
Changchun, China
Hunan Cancer Hospital
Changsha, China
West China Hospital, Sichuan University
Chengdu, China
Sichuan Provincial People's Hospital
Chengdu, China
Second Affiliated Hospital of Third Military Medical University
Chongqing, China
Fujian Cancer Hospital
Fuzhou, China
Southern Medical University Nanfang Hospital
Guangdong Province Guangzhou City, China
Sun yat-sen University Cancer Center
Guangzhou, China
Zhujiang Hospital, Southern Medical University
Guangzhou, China
Harbin Medical University Cancer Hospital
Harbin, China
Anhui Province Cancer Hospital
Hefei, China