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RECRUITING

NCT06073431

LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

Sponsor: University of Rochester

View on ClinicalTrials.gov

Summary

This study evaluates cancer-related weight and muscle mass loss, symptoms, and physical function (cachexia) in patients undergoing treatment for colorectal, lung, or pancreatic cancer that cannot be removed by surgery (unresectable) or is stage IV. Patients with these cancer types are at risk for developing cancer cachexia (CC), which is defined as weight loss, muscle loss, and fat loss due to cancer. CC has been associated with reduced physical performance, impaired quality of life, and poorer survival. Many studies that have evaluated treatments for cancer-related weight and muscle loss have aimed to treat all patients with weight loss exactly the same and, unfortunately, have not been successful. Like different cancer types, weight and muscle loss related to cancer may have different causes in different individuals and the best treatment strategy for this condition may not be a one-size-fits-all approach. Information gathered from this study may help researchers develop new diagnostic criteria for CC and design better treatments and clinical trials for cancer-related weight and muscle loss in the future to improve the quality of life in patients with advanced colorectal, lung, or pancreatic cancer.

Official title: Longitudinal Observational Trial to Uncover Subtypes of Cancer Cachexia

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

800

Start Date

2023-12-04

Completion Date

2028-09-30

Last Updated

2026-01-09

Healthy Volunteers

Conditions

Advanced Colorectal Carcinoma Advanced Lung Non-Small Cell Carcinoma Advanced Pancreatic Adenocarcinoma Stage IV Colorectal Cancer AJCC v8 Stage IV Lung Cancer AJCC v8 Stage IV Pancreatic Cancer AJCC v8 Unresectable Colorectal Carcinoma Unresectable Lung Non-Small Cell Carcinoma Unresectable Pancreatic Adenocarcinoma

Interventions

PROCEDURE

Biospecimen Collection

Undergo collection of blood and archived tumor samples

PROCEDURE

Computed Tomography

Undergo CT or PET/CT scan

OTHER

Electronic Health Record Review

Medical records reviewed

OTHER

Medical Device Usage and Evaluation

Wear actigraph

OTHER

Physical Performance Testing

Undergo physical function tests

PROCEDURE

Positron Emission Tomography

Undergo PET/CT scan

OTHER

Survey Administration

Complete surveys

Locations (225)

Mercy Hospital Fort Smith

Fort Smith, Arkansas, United States

Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, United States

Boulder Community Foothills Hospital

Boulder, Colorado, United States

Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, United States

Rocky Mountain Cancer Centers - Centennial

Centennial, Colorado, United States

The Women's Imaging Center

Denver, Colorado, United States

Colorado Blood Cancer Institute

Denver, Colorado, United States

Rocky Mountain Cancer Centers-Midtown

Denver, Colorado, United States

Rocky Mountain Cancer Centers-Rose

Denver, Colorado, United States

Rocky Mountain Cancer Centers - Swedish

Englewood, Colorado, United States

The Melanoma and Skin Cancer Institute

Englewood, Colorado, United States

Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado, United States

Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, United States

Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado, United States

Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, United States

Beebe South Coastal Health Campus

Millville, Delaware, United States

Helen F Graham Cancer Center

Newark, Delaware, United States

Medical Oncology Hematology Consultants PA

Newark, Delaware, United States

Christiana Care Health System-Christiana Hospital

Newark, Delaware, United States

Beebe Health Campus

Rehoboth Beach, Delaware, United States

Christiana Care Health System-Wilmington Hospital

Wilmington, Delaware, United States

MedStar Georgetown University Hospital

Washington D.C., District of Columbia, United States

Northside Hospital

Atlanta, Georgia, United States

Northeast Georgia Medical Center Braselton

Braselton, Georgia, United States

John B Amos Cancer Center

Columbus, Georgia, United States

Northside Hospital - Duluth

Duluth, Georgia, United States

Northeast Georgia Medical Center-Gainesville

Gainesville, Georgia, United States

The Longstreet Clinic - Gainesville

Gainesville, Georgia, United States

Northside Hospital - Gwinnett

Lawrenceville, Georgia, United States

Memorial Health University Medical Center

Savannah, Georgia, United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, United States

Tift Regional Medical Center

Tifton, Georgia, United States

South Georgia Medical Center/Pearlman Cancer Center

Valdosta, Georgia, United States

Hawaii Cancer Care Inc - Waterfront Plaza