Clinical Research Directory

Inclusion Criteria: 1. Aged ≥ 18 years or more; 2. acute ischemic stroke within 24 hours from onset to randomization; 3. NIHSS ≥6 points before randomization; 4. Internal carotid artery, or the middle cerebral artery M1 or M2 occlusion confirmed by CTA/MRA/DSA; 5. Baseline ASPECTS score ≥ 3 and ≤10, or cerebral infarction core volume \< 100ml; 6. The patient decides to undergo endovascular therapy; 7. The patient or patient's representative signs a written informed consent form. Exclusion Criteria: 1. CT or MR evidence of hemorrhage; 2. Pre-randomization rectal temperature ≥ 38℃ or axillary/tympanic temperature ≥ 37.5℃; 3. Currently pregnant or lactating (women patients); 4. Allergy to radiographic contrast agents, or nitinol devices; 5. Arterial tortuosity and/or other arterial disease that would prevent the device from reaching the target vessel; 6. Multiple vessel occlusion (e.g., bilateral anterior circulation, or occlusion of both anterior and posterior circulation); 7. Preexisting neurological or psychiatric disease that would confound the neurological functional evaluations; 8. Previous bleeding disorders, severe heart (especially congestive heart failure), liver or kidney disease, or sepsis; 9. Brain tumors with mass effect (except meningiomas) that are radiographically pleasant; 10. Intracranial aneurysm, arteriovenous malformation; 11. Any terminal illness with life expectancy less than 6 months; 12. Participating in other clinical trials.