Clinical Research Directory
Browse clinical research sites, groups, and studies.
Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents
Sponsor: AstraZeneca
Summary
The intention of the study is to demonstrate superiority of Saruparib (AZD5305) + physician's choice NHA relative to placebo + physician's choice NHA by assessment of radiographic progression-free survival (rPFS) in participants with mCSPC.
Official title: A Randomized, 2-cohort, Double-blind, Placebo-controlled, Phase III Study of Saruparib (AZD5305) in Combination With Physician's Choice New Hormonal Agents in Patients With HRRm and Non-HRRm Metastatic Castration-Sensitive Prostate Cancer (EvoPAR-Prostate01)
Key Details
Gender
MALE
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
1898
Start Date
2023-11-21
Completion Date
2031-04-30
Last Updated
2026-07-29
Healthy Volunteers
No
Interventions
Saruparib
Oral
Placebo
Oral
Abiraterone Acetate
Oral
Darolutamide
Oral
Enzalutamide
Oral
Locations (322)
Research Site
Chandler, Arizona, United States
Research Site
Gilbert, Arizona, United States
Research Site
Phoenix, Arizona, United States
Research Site
Tucson, Arizona, United States
Research Site
Little Rock, Arkansas, United States
Research Site
Springdale, Arkansas, United States
Research Site
Bakersfield, California, United States
Research Site
Fountain Valley, California, United States
Research Site
Fullerton, California, United States
Research Site
Los Angeles, California, United States
Research Site
Montebello, California, United States
Research Site
San Francisco, California, United States
Research Site
Santa Barbara, California, United States
Research Site
Santa Monica, California, United States
Research Site
Santa Rosa, California, United States
Research Site
Golden, Colorado, United States
Research Site
Lakewood, Colorado, United States
Research Site
New Haven, Connecticut, United States
Research Site
Atlanta, Georgia, United States
Research Site
Glenview, Illinois, United States
Research Site
Lake Barrington, Illinois, United States
Research Site
Fort Wayne, Indiana, United States
Research Site
Indianapolis, Indiana, United States
Research Site
Westwood, Kansas, United States
Research Site
Shreveport, Louisiana, United States
Research Site
Scarborough, Maine, United States
Research Site
Baltimore, Maryland, United States
Research Site
Baltimore, Maryland, United States
Research Site
Bethesda, Maryland, United States
Research Site
Towson, Maryland, United States
Research Site
Upper Marlboro, Maryland, United States
Research Site
Grand Rapids, Michigan, United States
Research Site
Troy, Michigan, United States
Research Site
Rochester, Minnesota, United States
Research Site
Bozeman, Montana, United States
Research Site
Las Vegas, Nevada, United States
Research Site
Las Vegas, Nevada, United States
Research Site
Camden, New Jersey, United States
Research Site
Albuquerque, New Mexico, United States
Research Site
East Syracuse, New York, United States
Research Site
New Hyde Park, New York, United States
Research Site
New York, New York, United States
Research Site
Syracuse, New York, United States
Research Site
Durham, North Carolina, United States
Research Site
Cincinnati, Ohio, United States
Research Site
Cincinnati, Ohio, United States
Research Site
Cleveland, Ohio, United States
Research Site
Cleveland, Ohio, United States
Research Site
Columbus, Ohio, United States
Research Site
Portland, Oregon, United States
Research Site
Bala-Cynwyd, Pennsylvania, United States
Research Site
Philadelphia, Pennsylvania, United States
Research Site
Pittsburgh, Pennsylvania, United States
Research Site
Providence, Rhode Island, United States
Research Site
Myrtle Beach, South Carolina, United States
Research Site
North Charleston, South Carolina, United States
Research Site
Sioux Falls, South Dakota, United States
Research Site
Germantown, Tennessee, United States
Research Site
Nashville, Tennessee, United States
Research Site
Dallas, Texas, United States
Research Site
Houston, Texas, United States
Research Site
San Antonio, Texas, United States
Research Site
Sugar Land, Texas, United States
Research Site
Tyler, Texas, United States
Research Site
Wichita Falls, Texas, United States
Research Site
Salt Lake City, Utah, United States
Research Site
Salt Lake City, Utah, United States
Research Site
St. George, Utah, United States
Research Site
Fairfax, Virginia, United States
Research Site
Spokane, Washington, United States
Research Site
Tacoma, Washington, United States
Research Site
Chermside, Australia
Research Site
Darlinghurst, Australia
Research Site
Hyde Park, Australia
Research Site
Kurralta Park, Australia
Research Site
Melbourne, Australia
Research Site
South Brisbane, Australia
Research Site
Graz, Austria
Research Site
Innsbruck, Austria
Research Site
Krems, Austria
Research Site
Linz, Austria
Research Site
Vienna, Austria
Research Site
Vienna, Austria
Research Site
Ghent, Belgium
Research Site
Kortrijk, Belgium
Research Site
Leuven, Belgium
Research Site
Curitiba, Brazil
Research Site
Pelotas, Brazil
Research Site
Porto Alegre, Brazil
Research Site
Rio de Janeiro, Brazil
Research Site
Salvador, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
Calgary, Alberta, Canada
Research Site
Calgary, Alberta, Canada
Research Site
Abbotsford British Columbia, British Columbia, Canada
Research Site
Abbotsford British Columbia, British Columbia, Canada
Research Site
Kelowna, British Columbia, Canada
Research Site
Vancouver, British Columbia, Canada