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A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
Sponsor: AstraZeneca
Summary
The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after receiving definitive concurrent chemoradiotherapy (cCRT).
Official title: A Phase III, Randomized, Open-Label, Multi-Center, Global Study of Volrustomig (MEDI5752) as Sequential Therapy Versus Observation in Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma, Who Have Not Progressed Following Definitive Concurrent Chemoradiotherapy (eVOLVE-HNSCC)
Key Details
Gender
All
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
1145
Start Date
2023-12-14
Completion Date
2031-02-28
Last Updated
2026-09-30
Healthy Volunteers
No
Interventions
volrustomig
volrustomig
Locations (306)
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Birmingham, Alabama, United States
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Phoenix, Arizona, United States
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Prescott Valley, Arizona, United States
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Springdale, Arkansas, United States
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Fountain Valley, California, United States
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Fullerton, California, United States
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Los Angeles, California, United States
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Orange, California, United States
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Santa Rosa, California, United States
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Whittier, California, United States
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Aurora, Colorado, United States
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Colorado Springs, Colorado, United States
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Lone Tree, Colorado, United States
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Washington D.C., District of Columbia, United States
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Fort Myers, Florida, United States
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Gainesville, Florida, United States
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Miami, Florida, United States
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Palm Bay, Florida, United States
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West Palm Beach, Florida, United States
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Niles, Illinois, United States
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Des Moines, Iowa, United States
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Kansas City, Kansas, United States
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Louisville, Kentucky, United States
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Baton Rouge, Louisiana, United States
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Shreveport, Louisiana, United States
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Baltimore, Maryland, United States
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Bethesda, Maryland, United States
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Hyattsville, Maryland, United States
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Towson, Maryland, United States
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Upper Marlboro, Maryland, United States
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Boston, Massachusetts, United States
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Fairhaven, Massachusetts, United States
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Ann Arbor, Michigan, United States
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Ann Arbor, Michigan, United States
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Minneapolis, Minnesota, United States
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Columbia, Missouri, United States
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St Louis, Missouri, United States
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St Louis, Missouri, United States
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East Brunswick, New Jersey, United States
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Hackensack, New Jersey, United States
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New Brunswick, New Jersey, United States
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Albuquerque, New Mexico, United States
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New York, New York, United States
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New York, New York, United States
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Stony Brook, New York, United States
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Charlotte, North Carolina, United States
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Winston-Salem, North Carolina, United States
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Cleveland, Ohio, United States
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Portland, Oregon, United States
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Portland, Oregon, United States
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Philadelphia, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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York, Pennsylvania, United States
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Sioux Falls, South Dakota, United States
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Sioux Falls, South Dakota, United States
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Nashville, Tennessee, United States
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Austin, Texas, United States
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Dallas, Texas, United States
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Flower Mound, Texas, United States
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Houston, Texas, United States
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Odessa, Texas, United States
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Tyler, Texas, United States
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Salt Lake City, Utah, United States
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West Jordan, Utah, United States
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Fairfax, Virginia, United States
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Norfolk, Virginia, United States
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Richmond, Virginia, United States
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Spokane, Washington, United States
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Tacoma, Washington, United States
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Tacoma, Washington, United States
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Graz, Austria
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Innsbruck, Austria
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Linz, Austria
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Salzburg, Austria
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Vienna, Austria
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Charleroi, Belgium
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Edegem, Belgium
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Jette, Belgium
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La Louvière, Belgium
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Namur, Belgium
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Barretos, Brazil
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Florianópolis, Brazil
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Fortaleza, Brazil
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Ijuí, Brazil
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Ipatinga, Brazil
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Londrina, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Ribeirão Preto, Brazil
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Rio de Janeiro, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Teresina, Brazil
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Calgary, Alberta, Canada
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Edmonton, Alberta, Canada
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Kelowna, British Columbia, Canada
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Kingston, Ontario, Canada
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London, Ontario, Canada
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Toronto, Ontario, Canada
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Chicoutimi, Quebec, Canada