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MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)
Sponsor: Pfizer
Summary
The purpose of this study is to learn about the study medicine called elranatamab.This study aims to compare elranatamab to other medicines for the treatment of MM (a type of cancer). This study is seeking participants who: * Are 18 years of age or older and have MM. * Have received treatments before for MM. * Have MM that has returned or not responded to their most recent treatment. Half of the participants will receive elranatamab. The other half of participants will receive a combination therapy selected by the study doctor. The selected combination therapy will include 2 to 3 different medicines commonly used to treat MM. Elranatamab will be given as a shot under the skin at the study clinic about once a week. This may change to a smaller number of shots later in the study. The medicines in the combination therapy will be taken by mouth (at home or at the study clinic) AND will be given either as: * a shot under the skin at the study clinic * through a needle in the vein at the study clinic The number of times these medicines will be taken depends on what combination therapy the study doctor selects. Participants may continue to receive elranatamab or a combination therapy until their MM is no longer responding. The study team will see how each participant is doing with the study treatment during regular visits at the study clinic. The study team will continue to follow-up with participants after study treatment with telephone contacts (or visits). The study will compare the experiences of people receiving elranatamab to those people receiving a combination therapy. This will help learn about the safety and how effective elranatamab is.
Official title: A PHASE 3, OPEN-LABEL STUDY OF ELRANATAMAB MONOTHERAPY VERSUS ELOTUZUMAB, POMALIDOMIDE, DEXAMETHASONE (EPd) OR POMALIDOMIDE, BORTEZOMIB, DEXAMETHASONE (PVd) OR CARFILZOMIB, DEXAMETHASONE (Kd) IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO RECEIVED PRIOR ANTI-CD38 DIRECTED THERAPY
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
492
Start Date
2024-02-08
Completion Date
2027-12-30
Last Updated
2026-08-24
Healthy Volunteers
No
Conditions
Interventions
Elranatamab
Elranatamab will be administered subcutaneously
Elotuzumab
Elotuzumab will be administered intravenously
Pomalidomide
Pomalidomide will be administered orally
Dexamethasone
Dexamethasone will be administered orally
Bortezomib
Bortezomib will be administered subcutaneously or intravenously
Carfilzomib
Carfilzomib will be administered intravenously
Locations (270)
Infirmary Cancer Care
Mobile, Alabama, United States
Western Regional Medical Center, Inc. dba. City of Hope Phoenix
Goodyear, Arizona, United States
Beverly Hills Cancer Center
Beverly Hills, California, United States
Clovis Community Medical Center
Clovis, California, United States
Community Cancer Institute
Clovis, California, United States
Clinical Research Advisors (Encino Satellite Location)
Encino, California, United States
University of California San Francisco
Fresno, California, United States
Community Regional Medical Center
Fresno, California, United States
Hoag Health Center Irvine
Irvine, California, United States
Hoag Hospital Irvine
Irvine, California, United States
Clinical Research Advisors (Korea Town Satellite Location)
Los Angeles, California, United States
Clinical Research Advisors (West Hollywood Satellite Location)
Los Angeles, California, United States
Valkyrie Clinical Trials
Los Angeles, California, United States
Hoag Memorial Hospital Presbyterian
Newport Beach, California, United States
Mission Community Hospital (Satellite Site)
Panorama City, California, United States
University of California Davis (UC Davis) Comprehensive Cancer Center
Sacramento, California, United States
University of California
Sacramento, California, United States
UCHealth Poudre Valley Hospital
Fort Collins, Colorado, United States
UCHealth Harmony
Fort Collins, Colorado, United States
UCHealth Greeley Hospital
Greeley, Colorado, United States
UCHealth Longs Peak Hospital
Longmont, Colorado, United States
UCHealth Longs Peak Medical Center
Longmont, Colorado, United States
UCHealth - Medical Center of the Rockies
Loveland, Colorado, United States
Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center
Coral Gables, Florida, United States
University of Miami Hospital and Clinics - Deerfield Beach
Deerfield Beach, Florida, United States
Sylvester Comprehensive Cancer Center- Doral
Doral, Florida, United States
Sylvester Comprehensive Cancer Center - Hollywood
Hollywood, Florida, United States
Sylvester Comprehensive Cancer Center
Miami, Florida, United States
University of Miami Hospital and Clinics - Griffin Cancer Research Building
Miami, Florida, United States
University of Miami Hospital and Clinics
Miami, Florida, United States
Baptist Hospital of Miami
Miami, Florida, United States
Miami Cancer Institute at Baptist Health, Inc.
Miami, Florida, United States
Sylvester Comprehensive Cancer Center- Kendall
Miami, Florida, United States
BRCR Global
Plantation, Florida, United States
BRCR Medical Center Inc
Plantation, Florida, United States
Brcr Medical Center, Inc.
Plantation, Florida, United States
HCA Florida Westside Hospital
Plantation, Florida, United States
BRCR Medical Center Inc.
Tamarac, Florida, United States
Endeavor Health - Swedish Hospital
Chicago, Illinois, United States
Endeavor Health - Evanston Hospital
Evanston, Illinois, United States
Endeavor Health - Glenbrook Hospital Ambulatory Care Center
Glenview, Illinois, United States
Endeavor Health - Highland Park Hospital Health Center 1
Highland Park, Illinois, United States
Simmons Cancer Institute at SIU
Springfield, Illinois, United States
Springfield Clinic Main Campus
Springfield, Illinois, United States
HSHS St. John's Hospital
Springfield, Illinois, United States
Springfield Memorial Hospital
Springfield, Illinois, United States
Midwestern Regional Medical Center, Inc. dba City of Hope Chicago
Zion, Illinois, United States
Community Health Network, Inc.
Indianapolis, Indiana, United States
Community Health Network, Inc.
Indianapolis, Indiana, United States
Community Health Network, Inc.
Indianapolis, Indiana, United States
American Oncology Partners, P.A. Dba MidAmerica Cancer Care
Kansas City, Kansas, United States
Ascentist Doctors' Hospital
Leawood, Kansas, United States
American Oncology Partners, P.A. Dba MidAmerica Cancer Care
Merriam, Kansas, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
BIDMC Research Pharmacy
Boston, Massachusetts, United States
American Oncology Partners, P.A. Dba MidAmerica Cancer Care
Belton, Missouri, United States
MIVA Medical
Independence, Missouri, United States
Kansas City VA Medical Center
Kansas City, Missouri, United States
American Oncology Partners, P.A. Dba MidAmerica Cancer Care
Kansas City, Missouri, United States
Bryan Medical Center
Lincoln, Nebraska, United States
NHO Revive Research Institute, LLC
Lincoln, Nebraska, United States
Atlantic Health System Morristown Medical Center
Morristown, New Jersey, United States
WMCHealth Advanced Physician Services
Hawthorne, New York, United States
Northwell Health/ RJ Zuckerberg Cancer Center
Lake Success, New York, United States
North Shore University Hospital
Manhasset, New York, United States
Long Island Jewish Medical Center
New Hyde Park, New York, United States
Westchester Medical Center
Valhalla, New York, United States
Sanford Fargo Medical Center
Fargo, North Dakota, United States
Oncology Hematology Care Clinical Trials, LLC
Cincinnati, Ohio, United States
TriHealth Cancer Institute-Good Samaritan Hospital
Cincinnati, Ohio, United States
Oncology Hematology Care Clinical Trials, LLC
Cincinnati, Ohio, United States
The Jewish Hospital
Cincinnati, Ohio, United States
Oncology Hematology Care Clinical Trials, LLC
Cincinnati, Ohio, United States
TriHealth Cancer Institute- Thomas Comprehensive Care Center
Cincinnati, Ohio, United States
Oncology Hematology Care Clinical Trials, LLC
Cincinnati, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
AHN West Penn Hospital
Pittsburgh, Pennsylvania, United States
Rodhe Island Hospital
Providence, Rhode Island, United States
The Miriam Hospital
Providence, Rhode Island, United States
St Francis Cancer Center
Greenville, South Carolina, United States
Ascension St. Thomas Hospital
Nashville, Tennessee, United States
Tennessee Oncology, PLLC - Investigational Drug Services
Nashville, Tennessee, United States
Tennessee Oncology, PLLC - Nashville Elliston Place Plaza Center for Blood Cancers
Nashville, Tennessee, United States
Tennessee Oncology, PLLC - Nashville Elliston Place Plaza DDU
Nashville, Tennessee, United States
Tennessee Oncology, PLLC - Nashville Elliston Place Plaza Medical Oncology & Hematology
Nashville, Tennessee, United States
Baylor University Medical Center, Investigational Drug Services, Department of Pharmacy
Dallas, Texas, United States
Baylor University Medical Center
Dallas, Texas, United States
Houston Methodist Cancer Center Infusion
Houston, Texas, United States
Houston Methodist Hospital - Department of Pharmacy
Houston, Texas, United States
Houston Methodist Hospital Cancer Center
Houston, Texas, United States
Houston Methodist Clear Lake Hospital (St. John)
Houston, Texas, United States
Houston Methodist Willowbrook Hospital
Houston, Texas, United States
Houston Methodist West Hospital
Houston, Texas, United States
Joe Arrington Cancer Research and Treatment Center
Lubbock, Texas, United States
Houston Methodist Sugar Land Hospital
Sugar Land, Texas, United States
Baylor Scott & White Medical Center - Temple
Temple, Texas, United States
Houston Methodist The Woodlands Hospital
The Woodlands, Texas, United States
WVU Cancer Institute
Morgantown, West Virginia, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin, United States
University of Wisconsin Carbone Cancer Center-University Hospital
Madison, Wisconsin, United States