Clinical Research Directory
Browse clinical research sites, groups, and studies.
ACP-204 in Adults With Alzheimer's Disease Psychosis
Sponsor: ACADIA Pharmaceuticals Inc.
Summary
This is a master protocol for 3 independent, seamlessly enrolling, multicenter, randomized, double-blind, placebo-controlled, parallel-group studies in patients with ADP * Substudy 1 (Phase 2) will evaluate efficacy and dose response of ACP-204 30 and 60 mg vs placebo. This substudy will be initiated first. * Substudies 2A and 2B (both: Phase 3) will be confirmatory studies of either both doses (ACP-204 30 and 60 mg, respectively) or a single dose from Part 1 vs placebo. Substudies 2A and 2B will be performed independently of each other and will commence after enrollment of Part 1. All 3 substudies will be analyzed independently of each other. Each substudy individually will consist of a screening period (up to 49 days); a double-blind treatment period (6 weeks); a safety follow-up period (30 days) for patients not rolling over into an open-label extension study; and vital status follow-up (for patients who terminated their substudy early).
Official title: A Master Protocol for Three Independent, Seamlessly Enrolling, Double-blind, Placebo-controlled Efficacy and Safety Studies of ACP-204 in Adults With Alzheimer's Disease Psychosis
Key Details
Gender
All
Age Range
55 Years - 95 Years
Study Type
INTERVENTIONAL
Enrollment
1074
Start Date
2023-11-14
Completion Date
2028-02
Last Updated
2026-10-19
Healthy Volunteers
No
Conditions
Interventions
ACP-204
ACP-204 is a potent and selective antagonist/inverse agonist of 5-hydroxytryptamine (serotonin) receptor subtype 2A.
Placebo
ACP-204 matching placebo
Locations (154)
Chandler Clinical Trials
Chandler, Arizona, United States
Clinical Endpoint LLC
Scottsdale, Arizona, United States
Advanced Research Center, Inc.
Anaheim, California, United States
ATP Clinical Research
Costa Mesa, California, United States
Neuro-Pain Medical Center
Fresno, California, United States
National Institute of Clinical Research
Garden Grove, California, United States
Havana Research Institute LLC
Pasadena, California, United States
Quantum Clinical Research, Inc.
Pasadena, California, United States
Humanity Clinical Research Corp
Aventura, Florida, United States
Arrow Clinical Trials
Daytona Beach, Florida, United States
First Excellent Research Group
Doral, Florida, United States
New Life Medical Research Center Inc.
Hialeah, Florida, United States
Reliable Clinical Research LLC.
Hialeah, Florida, United States
Homestead Associates in Research Inc.
Miami, Florida, United States
Premier Clinical Research Institute, Inc.
Miami, Florida, United States
Central Miami Medical Institute
Miami, Florida, United States
Advanced Clinical Research Network, Corp
Miami, Florida, United States
Verus Clinical Research
Miami, Florida, United States
Future Care Solution, LLC
Miami, Florida, United States
MediClear Medical & Research Center, Inc.
Miami, Florida, United States
ABBA Medical Group LLC
Miami, Florida, United States
Visionary Investigators Network
Miami, Florida, United States
Quantum Clinical Trials
Miami Beach, Florida, United States
New Med Research
Miami Gardens, Florida, United States
Floridian Neuroscience Institutue
Miami Lakes, Florida, United States
Combined Research Orlando Phase I IV
Orlando, Florida, United States
Psych Me Medical Research Inc
Tampa, Florida, United States
Neuroscience Research Institute
West Palm Beach, Florida, United States
Agile Clinical Research Trials LLC
Atlanta, Georgia, United States
Revive Research Institute, Inc.
Elgin, Illinois, United States
Grace Research, LLC
Shreveport, Louisiana, United States
CBH Health LLC, dba CenExcel Gaithersburg
Gaithersburg, Maryland, United States
Khan Revive Research Institute
Rochester Hills, Michigan, United States
Tekton Research, LLC
St Louis, Missouri, United States
Alivation Research, LLC
Lincoln, Nebraska, United States
Dent Neurologic Institute
Amherst, New York, United States
Finger Lakes Clinical Research
Rochester, New York, United States
SUNY Upstate Medical University
Syracuse, New York, United States
Regional Neurological Associates
The Bronx, New York, United States
Insight Clinical Trials LLC
Beachwood, Ohio, United States
Valley Medical Research
Centerville, Ohio, United States
NDx Clinical Research Inc.
Dayton, Ohio, United States
Abington Neurological Associates
Abington, Pennsylvania, United States
Horizon Clinical Research Group
Cypress, Texas, United States
Prolato Clinical Research Center-Patton
Houston, Texas, United States
University of Texas Health Science Center
Houston, Texas, United States
Clinical Trial Network LLC
Houston, Texas, United States
Kaleidoscope Clinical Research
Houston, Texas, United States
Steven South Goldstein MD and Associates
Houston, Texas, United States
World Research Link
Pasadena, Texas, United States
R & H Clinical Research Inc.
Stafford, Texas, United States
Tranquil Clinical Research
Webster, Texas, United States
Clinica Neurologica e Neurocirurgica de Joinville
Joinville, Santa Catarina, Brazil
L2IP - Instituto de Pesquisas Clínicas Ltda
Brasília, Brazil
Hospital Universitario de Brasilia
Brasília, Brazil
CECPAR Centro de Estudos Clinicos do Parana
Curitiba, Brazil
TrialTech Tecnologia com Pesquisas em Medicamentos
Curitiba, Brazil
Inst. de Neurologia de Curitiba Hospital Ecoville
Curitiba, Brazil
Instituto Mederi de Pesquisa e Saude
Passo Fundo, Brazil
Hospital Moinhos de Vento
Porto Alegre, Brazil
Nucleo de Pesquisa Clínica do Rio Grande do Sul
Porto Alegre, Brazil
Ruschel Medicina e Pesquisa Clínica
Rio de Janeiro, Brazil
Facili-Centro Integrado de Psiquiatria
São Bernardo do Campo, Brazil
BR Trials-Ensaios Clinicos e Consultoria
São Paulo, Brazil
Hospital Sao Paulo
São Paulo, Brazil
Santa Paula Hospital Clinical Research Center
São Paulo, Brazil
Hospital das Clínicas da Faculdade de Medicina USP
São Paulo, Brazil
ET Dr. Ivo Natsov - AIPSMC in Psychiatry
Cherven Bryag, Bulgaria
Medical Center Lifemed
Kardzhali, Bulgaria
DCC "Higia"
Pazardzhik, Bulgaria
Medical center Medconsult Pleven OOD
Pleven, Bulgaria
UMHAT Sv. Georgi EAD
Plovdiv, Bulgaria
Medical center Spectar-Plovdic EOOD
Plovdiv, Bulgaria
Mental Health Centre - Prof. N Shipkovenski EOOD
Sofia, Bulgaria
DCC St. Vrach and St. St. Kuzma and Damian OOD
Sofia, Bulgaria
UMHAT "Alexandrovska" EAD
Sofia, Bulgaria
UMHAT Alexandrovska EAD
Sofia, Bulgaria
Medical Center Hera EOOD
Sofia, Bulgaria
Medical Center Intermedica
Sofia, Bulgaria
UMHAT Prof. Dr. St. Kirkovich AD
Stara Zagora, Bulgaria
Psicomed Estudios Medicos
Antofagasta, Chile
Biomedica Research Group
Santiago, Chile
Especialidades Medicas L y S
Santiago, Chile
CIC de la Universidad Catolica CICUC
Santiago, Chile
BRAIN-SOUL THERAPY s.r.o.
Kladno, Czech Republic, Czechia
Ad71 S.R.O.
Prague, Czech Republic, Czechia
Fakultni nemocnice u sv. Anny v Brne
Brno, Czechia
NEUROHK s.r.o
Choceň, Czechia
CLINTRIAL s.r.o.
Prague, Czechia
FORBELI s.r.o.
Prague, Czechia
INEP medical s.r.o
Prague, Czechia
Vestra Clinics s.r.o.
Rychnov nad Kněžnou, Czechia
Hopital Neurologique Bron
Bron, France
Centre pour Personnes Âgées
Colmar, France
Centre Memoire Ressources Recherche CMRR
Dijon, France
CHU de Limoges-Hopital Dupuytren
Limoges, France
Hospices Civils de Lyon HCL
Lyon, France
Hôpital Lariboisière
Paris, France
Hopital BROCA
Paris, France
CHU Rouen-Hospital Charles Nicolle
Rouen, France