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A Clinical Study of MK-4208/TERN-701 in Participants With Chronic Myeloid Leukemia (CML) (MK-4208-003/Tern701-1012/CARDINAL)
Sponsor: Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Summary
Researchers are looking for a new way to treat a blood cancer called chronic myeloid leukemia (CML). Researchers want to learn if MK-4208 (Tern-701) can treat this type of blood cancer. The goal of this study is to learn about the safety of different doses (amounts) of MK-4208 (Tern-701) and if people tolerate them. Researchers also want to find the highest dose of MK-4208 (Tern-701) that people can tolerate and may work to treat blood cancer.
Official title: A Phase 1/2 Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of TERN-701 in Participants With Chronic Myeloid Leukemia
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
330
Start Date
2024-03-26
Completion Date
2030-05-31
Last Updated
2026-10-15
Healthy Volunteers
No
Conditions
Interventions
MK-4208
40 mg and 100 mg oral tablets
Locations (54)
University of Alabama Medicine (UAB Medicine)
Birmingham, Alabama, United States
Banner MD Anderson Cancer Center
Gilbert, Arizona, United States
UC Irvine Health
Orange, California, United States
Rocky Mountain Cancer Centers, LLP
Lone Tree, Colorado, United States
Florida Cancer Specialists - South Region Research Office
Fort Myers, Florida, United States
Florida Cancer Affiliates - Ocala
Ocala, Florida, United States
Florida Cancer Specialists - North Region Research Office
St. Petersburg, Florida, United States
Florida Cancer Specialists - East Region Research Office
West Palm Beach, Florida, United States
Georgia Cancer Center at Augusta University
Augusta, Georgia, United States
Memorial Sloan Kettering Cancer Center - Main Campus
New York, New York, United States
Atrium Health Levine Cancer Institute
Winston-Salem, North Carolina, United States
Willamette Valley Cancer Institute and Research Center
Eugene, Oregon, United States
Oregon Health & Science University
Portland, Oregon, United States
Thomas Jefferson University - Center City (Philadelphia)
Philadelphia, Pennsylvania, United States
Tristar BMT
Nashville, Tennessee, United States
The University of Texas M.D. Anderson Cancer Center
Houston, Texas, United States
Huntsman Cancer Institute
Salt Lake City, Utah, United States
Fred Hutchinson Cancer Center
Seattle, Washington, United States
Royal Adelaide Hospital
Adelaide, South Australia, Australia
Monash Medical Centre
Clayton, Victoria, Australia
Peter MacCallum Cancer Centre
Melbourne, Victoria, Australia
Royal Perth Hospital
Perth, Western Australia, Australia
Centre Léon Bérard
Lyon, Auvergne-Rhône-Alpes, France
Institut Bergonié
Bordeaux, France
Institut Paoli Calmettes
Marseille, France
CHU de Nantes (University Hospital of Nantes) - Hôtel Dieu
Nantes, France
Hôpital Saint Louis
Paris, France
Centre Hospitalier Lyon-Sud
Pierre-Bénite, France
Universitätsklinikum Aachen
Aachen, Germany
Charité Campus Virchow-Klinikum - Universitätsmedizin Berlin
Berlin, Germany
Universitätsklinikum Frankfurt
Frankfurt am Main, Germany
Medizinische Hochschule Hannover
Hanover, Germany
Universitätsklinikum Jena
Jena, Germany
Universitätsklinikum Mannheim
Mannheim, Germany
Klinikum rechts der lsar der Technischen Universität München
München, Germany
Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant'Orsola
Bologna, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy
Fondazione IRCCS San Gerardo dei Tintori - SC Centro di Ricerca Fase I
Monza, Italy
Fondazione IRCCS San Gerardo dei Tintori
Monza, Italy
Auckland City Hospital
Auckland, New Zealand
Christchurch Hospital
Christchurch, New Zealand
Uijeorigbu Eulji Medical Center, Eulji University
Uijeongbu-si, Gyeonggi-do, South Korea
Hallym University Sacred Heart Hospital
Anyang-si, Gyeonggido, South Korea
Dong-A University hospital
Busan, South Korea
Keimyung University Dongsan Hospital
Daegu, South Korea
Hospital Universitari Vall d'Hebrón
Barcelona, Spain
Hospital Clínic de Barcelona
Barcelona, Spain
Hospital Universitari Germans Trias i Pujol (ICO Badalona)
Barcelona, Spain
Hospital Universitario de Gran Canaria Doctor Negrín
Las Palmas, Spain
Hospital Universitario de La Princesa
Madrid, Spain
Hospital Universitario Ramón y Cajal
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital de Día Quirónsalud Zaragoza
Zaragoza, Spain
Imperial College Healthcare NHS Trust
London, England, United Kingdom