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Study of ALXN2220 Versus Placebo in Adults With ATTR-CM
Sponsor: Alexion Pharmaceuticals, Inc.
Summary
The primary objective of this study is to access the efficacy of ALXN2220 in the treatment of adult participants with ATTR-CM by evaluating the difference between the ALXN2220 and placebo groups as assessed by the total occurrences of all-cause mortality (ACM) and cardiovascular (CV) clinical events.
Official title: A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Amyloid Depleter ALXN2220 in Adult Participants With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
1182
Start Date
2024-01-11
Completion Date
2028-04-05
Last Updated
2026-10-22
Healthy Volunteers
No
Conditions
Interventions
ALXN2220
Participants will receive ALXN2220 via IV infusion.
Placebo
Participants will receive placebo via IV infusion.
Locations (213)
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Irvine, California, United States
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La Jolla, California, United States
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Palo Alto, California, United States
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San Francisco, California, United States
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Aurora, Colorado, United States
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Washington D.C., District of Columbia, United States
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Jacksonville, Florida, United States
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Weston, Florida, United States
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Atlanta, Georgia, United States
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Atlanta, Georgia, United States
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Chicago, Illinois, United States
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Indianapolis, Indiana, United States
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Boston, Massachusetts, United States
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Boston, Massachusetts, United States
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Kansas City, Missouri, United States
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St Louis, Missouri, United States
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New York, New York, United States
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New York, New York, United States
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Stony Brook, New York, United States
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Chapel Hill, North Carolina, United States
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Durham, North Carolina, United States
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Cleveland, Ohio, United States
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Columbus, Ohio, United States
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Portland, Oregon, United States
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Danville, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Charleston, South Carolina, United States
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Greenville, South Carolina, United States
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Memphis, Tennessee, United States
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Fort Worth, Texas, United States
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Houston, Texas, United States
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Salt Lake City, Utah, United States
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Falls Church, Virginia, United States
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Richmond, Virginia, United States
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Seattle, Washington, United States
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Madison, Wisconsin, United States
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Buenos Aires, Argentina
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CABA, Argentina
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Ciudad de Buenos Aires, Argentina
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Ciudad de Buenos Aires, Argentina
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Córdoba, Argentina
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Bedford Park, Australia
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Box Hill, Australia
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Brisbane, Australia
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Darlinghurst, Australia
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Joondalup, Australia
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Melbourne, Australia
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Westmead, Australia
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Graz, Austria
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Innsbruck, Austria
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Vienna, Austria
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Vienna, Austria
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Wels, Austria
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Bruges, Belgium
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Brussels, Belgium
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Genk, Belgium
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Aracaju, Brazil
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Campinas, Brazil
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Fortaleza, Brazil
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Porto Alegre, Brazil
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Ribeirão Preto, Brazil
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Ribeirão Preto, Brazil
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Rio de Janeiro, Brazil
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Rio de Janeiro, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Calgary, Alberta, Canada
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Winnipeg, Manitoba, Canada
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London, Ontario, Canada
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Toronto, Ontario, Canada
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Chicoutimi, Quebec, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Rimouski, Quebec, Canada
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Beijing, China
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Beijing, China
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Beijing, China
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Beijing, China
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Changsha, China
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Chengdu, China
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Chengdu, China
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Chongqing, China
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Fuzhou, China
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Guangzhou, China
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Guiyang, China
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Hangzhou, China
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Hangzhou, China
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Harbin, China
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Hefei, China
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Jinan, China
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Nanjing, China
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Shanghai, China
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Tianjin, China
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Wuhan, China
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Xi'an, China
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Prague, Czechia
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Prague, Czechia
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Aarhus, Denmark