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A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor
Sponsor: Novo Nordisk A/S
Summary
This study will look at how well CagriSema helps people with type 2 diabetes lower their blood sugar and body weight. CagriSema is a new investigational medicine. Doctors may not yet prescribe CagriSema. CagriSema will be compared to a medicine called tirzepatide that doctors may prescribe in some countries. Participants will get either CagriSema or tirzepatide. Which treatment participant get is decided by chance like flipping a coin. Participant will have an equal chance of receiving either drug. For each participant, the study will last for up to one and a half years.
Official title: Efficacy and Safety of Co-administered Cagrilintide and Semaglutide (CagriSema) 2.4 mg/2.4 mg s.c. Once Weekly Versus Tirzepatide 15 mg s.c. Once Weekly in Participants With Type 2 Diabetes Inadequately Controlled on Metformin With or Without an SGLT2 Inhibitor
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1024
Start Date
2024-01-16
Completion Date
2026-04-06
Last Updated
2026-10-19
Healthy Volunteers
No
Conditions
Interventions
Cagrilintide
Cagrilintide will be administered subcutaneously.
Semaglutide
Semaglutide will be administered subcutaneously.
Tirzepatide
Tirzepatide will be administered subcutaneously.
Locations (197)
Synexus Clin Res-Birmingham
Birmingham, Alabama, United States
Univ of Alabama_Birmingham
Birmingham, Alabama, United States
Prime Medical Group, LLC
Gilbert, Arizona, United States
Velocity Clinical Research-Phoenix
Phoenix, Arizona, United States
Synexus Rsch /Cnt Phnx Med C
Phoenix, Arizona, United States
Arkansas Clinical Research
Little Rock, Arkansas, United States
Unity Health-Searcy Medical Center
Searcy, Arkansas, United States
Velocity Clin Res-Chula Vista
Chula Vista, California, United States
Headlands Research California, LLC
Escondido, California, United States
Neighborhood Healthcare
Escondido, California, United States
St. Jude Heritage Yorba Linda - Pediatric Ste D
Fullerton, California, United States
Diabetes & Endocrine Specialists - La Mesa
La Mesa, California, United States
Diabetes and Endocrine Specialists - La Mesa
La Mesa, California, United States
Velocity Clin Res San Diego
La Mesa, California, United States
Headlands Research CTR Lincoln
Lincoln, California, United States
Loma Linda Univ Hlth Cr Endo
Loma Linda, California, United States
Valley Clinical Trials, Inc.
Northridge, California, United States
Desert Oasis Healthcare
Palm Springs, California, United States
Velocity Clin Res - Panorama
Panorama City, California, United States
Western University of Health Sciences
Pomona, California, United States
Endocrinology Josel Cabaccan
San Jose, California, United States
Mills-Peninsula Medical Center
San Mateo, California, United States
NorCal Endocrinology and Internal Medicine
San Ramon, California, United States
Premier Medical Center, Inc.
Toluca Lake, California, United States
Velocity Clin Res - Panorama
Van Nuys, California, United States
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
University of Colorado Hospital
Aurora, Colorado, United States
Optumcare Clinical Trials,LLC-Golden
Colorado Springs, Colorado, United States
Northeast Res Inst. Inc.
Jacksonville, Florida, United States
Bioclinical Research Alliance
Miami, Florida, United States
New Horizon Research Center
Miami, Florida, United States
South Broward Research LLC
Miramar, Florida, United States
West Orange Endocrinology
Ocoee, Florida, United States
Optimal Research Sites
Orange City, Florida, United States
Trans Res Inst for Met & Diab
Orlando, Florida, United States
Oviedo Medical Research, LLC
Oviedo, Florida, United States
Center for Diab,Obes & Metab
Pembroke Pines, Florida, United States
Hope Clin Res & Wellness
Conyers, Georgia, United States
Center for Adv Res & Education
Gainesville, Georgia, United States
Urban Family Practice Assoc
Marietta, Georgia, United States
Endocrine Research Solutions
Roswell, Georgia, United States
Pacific Diabetes & Endo Ctr
Honolulu, Hawaii, United States
St. Luke's Health System
Boise, Idaho, United States
Solaris Clinical Research
Meridian, Idaho, United States
Cedar-Crosse Research Center
Chicago, Illinois, United States
Clinical Invest Special_Gurnee
Gurnee, Illinois, United States
Endeavor Health
Skokie, Illinois, United States
Evanston Premier Hlthcr Res
Skokie, Illinois, United States
American Health Network of Indiana, LLC_Greenfield
Greenfield, Indiana, United States
Iowa Diabetes & Endo Res Ctr
West Des Moines, Iowa, United States
Cotton-O'Neil Diab & Endo Ctr
Topeka, Kansas, United States
Velocity Clin Res Lafayette
Lafayette, Louisiana, United States
MedStar Hlth Res Institute
Hyattsville, Maryland, United States
Joslin Diabetes Center
Boston, Massachusetts, United States
International Diabetes Center
Minneapolis, Minnesota, United States
Belzoni Clinical Research
Belzoni, Mississippi, United States
Velocity Clin Res Gulfport
Gulfport, Mississippi, United States
Diabetes & Endo Specialists Inc
Chesterfield, Missouri, United States
StudyMetrix Research LLC
City of Saint Peters, Missouri, United States
Amicis Centers of Clinical Research
St Louis, Missouri, United States
Velocity Clin Res Albuquerque
Albuquerque, New Mexico, United States
AMC Community Endocrinology
Albany, New York, United States
Velocity Clin Res Syracuse
East Syracuse, New York, United States
Southgate Medical Group, LLP
West Seneca, New York, United States
UNC Eastowne Clinical Research Unit
Chapel Hill, North Carolina, United States
PharmQuest Life Sciences LLC
Greensboro, North Carolina, United States
Carteret Medical Group
Morehead City, North Carolina, United States
Centricity Rsrch MHCity Multi
Morehead City, North Carolina, United States
Piedmont Healthcare/Research
Statesville, North Carolina, United States
Accellacare
Wilmington, North Carolina, United States
Plains Clinical Research Center, LLC
Fargo, North Dakota, United States
Remington Davis Inc
Columbus, Ohio, United States
Advanced Medical Research
Maumee, Ohio, United States
New Venture Medical Research
Wadsworth, Ohio, United States
Lynn Institute of Norman
Norman, Oklahoma, United States
CCT Research
Horsham, Pennsylvania, United States
Thomas Jefferson University_Philadelphia
Philadelphia, Pennsylvania, United States
Clinical Res Collaborative
Cumberland, Rhode Island, United States
Velocity Clin Res Providence
East Greenwich, Rhode Island, United States
Velocity Clinical Res-Anderson
Anderson, South Carolina, United States
Trial Management Associates
Myrtle Beach, South Carolina, United States
Hillcrest Clinical Research
Simpsonville, South Carolina, United States
Spartanburg Medical Research
Spartanburg, South Carolina, United States
AM Diabetes And Endocrinology Center
Bartlett, Tennessee, United States
Holston Medical Group Pc
Bristol, Tennessee, United States
Univ Diab & Endo Consultants
Chattanooga, Tennessee, United States
Jackson Clinic
Jackson, Tennessee, United States
Holston Medical Group
Kingsport, Tennessee, United States
Clinical Neuroscience Solutions
Memphis, Tennessee, United States
HealthStar Physicians PC
Morristown, Tennessee, United States
Clinical Research Associates
Nashville, Tennessee, United States
Arlington Family Res. Ctr Inc
Arlington, Texas, United States
Velocity Clin Res
Austin, Texas, United States
UT Health University of Texas
Bellaire, Texas, United States
Velocity Clin Res, Dallas
Dallas, Texas, United States
North Texas Endocrine Center
Dallas, Texas, United States
Synexus Clin Res Dallas
Dallas, Texas, United States
Cedar Health Research
Dallas, Texas, United States
PrimeCare Medical Group
Houston, Texas, United States
JCCT- Juno NW Houston
Houston, Texas, United States