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Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease
Sponsor: Bristol-Myers Squibb
Summary
The purpose of this study is to assess the effectiveness, safety, and tolerability of BMS-986446 an Anti-MTBR Tau Monoclonal Antibody in participants with Early Alzheimer's Disease.
Official title: A Randomized, Double-blind, Placebo-controlled, Global Proof-of-concept Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986446, an Anti-MTBR Tau Monoclonal Antibody, in Participants With Early Alzheimer's Disease (TargetTau-1)
Key Details
Gender
All
Age Range
50 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
310
Start Date
2024-03-20
Completion Date
2028-04-17
Last Updated
2026-11-02
Healthy Volunteers
No
Conditions
Interventions
BMS-986446
Specified dose on specified days
Placebo
Specified dose on specified days
Locations (176)
Local Institution - 0068
Chandler, Arizona, United States
Local Institution - 0102
Gilbert, Arizona, United States
Local Institution - 0019
Phoenix, Arizona, United States
Local Institution - 0018
Scottsdale, Arizona, United States
Local Institution - 0026
Scottsdale, Arizona, United States
Local Institution - 0077
Tucson, Arizona, United States
Local Institution - 0038
Tucson, Arizona, United States
Local Institution - 0164
Encino, California, United States
Local Institution - 0139
Fullerton, California, United States
Local Institution - 0191
Irvine, California, United States
Local Institution - 0234
Long Beach, California, United States
Local Institution - 0142
Los Alamitos, California, United States
Local Institution - 0037
Napa, California, United States
Local Institution - 0209
Sacramento, California, United States
Local Institution - 0052
San Francisco, California, United States
Local Institution - 0137
Santa Ana, California, United States
Local Institution - 0046
Sherman Oaks, California, United States
Local Institution - 0106
Danbury, Connecticut, United States
Local Institution - 0148
New Haven, Connecticut, United States
Local Institution - 0056
New Haven, Connecticut, United States
Local Institution - 0153
Stamford, Connecticut, United States
Local Institution - 0022
Altamonte Springs, Florida, United States
Local Institution - 0048
Atlantis, Florida, United States
Local Institution - 0228
Boca Raton, Florida, United States
Local Institution - 0250
Boca Raton, Florida, United States
Local Institution - 0224
Bradenton, Florida, United States
Local Institution - 0020
Clermont, Florida, United States
Local Institution - 0009
Daytona Beach, Florida, United States
Local Institution - 0213
Fort Myers, Florida, United States
Local Institution - 0059
Greenacres City, Florida, United States
Local Institution - 0207
Hialeah, Florida, United States
Local Institution - 0212
Hialeah, Florida, United States
Local Institution - 0198
Hialeah, Florida, United States
Local Institution - 0151
Lady Lake, Florida, United States
Local Institution - 0146
Lakeland, Florida, United States
Local Institution - 0192
Maitland, Florida, United States
Local Institution - 0143
Maitland, Florida, United States
Local Institution - 0027
Merritt Island, Florida, United States
Local Institution - 0203
Miami, Florida, United States
Local Institution - 0058
Miami, Florida, United States
Local Institution - 0034
Miami, Florida, United States
Local Institution - 0211
Miami, Florida, United States
Local Institution - 0195
Miami, Florida, United States
Local Institution - 0014
Miami, Florida, United States
Local Institution - 0005
Miami, Florida, United States
Local Institution - 0208
Miami, Florida, United States
Local Institution - 0013
Miami, Florida, United States
Local Institution - 0008
Miami, Florida, United States
Local Institution - 0199
Miami, Florida, United States
Local Institution - 0206
Miami, Florida, United States
Local Institution - 0176
Miami, Florida, United States
Local Institution - 0071
Miami, Florida, United States
Local Institution - 0156
Miami, Florida, United States
Local Institution - 0249
Miami, Florida, United States
Local Institution - 0039
Miami, Florida, United States
Local Institution - 0225
Miami, Florida, United States
Local Institution - 0197
Miami Springs, Florida, United States
Local Institution - 0217
Naples, Florida, United States
Local Institution - 0017
New Port Richey, Florida, United States
Local Institution - 0144
Ocala, Florida, United States
Local Institution - 0202
Orlando, Florida, United States
Local Institution - 0219
Orlando, Florida, United States
Local Institution - 0035
Orlando, Florida, United States
Local Institution - 0238
Orlando, Florida, United States
Local Institution - 0210
Port Orange, Florida, United States
Local Institution - 0204
Sarasota, Florida, United States
Local Institution - 0012
Stuart, Florida, United States
Local Institution - 0136
Stuart, Florida, United States
Local Institution - 0200
Tampa, Florida, United States
Local Institution - 0080
Tampa, Florida, United States
Local Institution - 0087
Tampa, Florida, United States
Local Institution - 0042
Tampa, Florida, United States
Local Institution - 0194
Viera, Florida, United States
Local Institution - 0011
Wellington, Florida, United States
Local Institution - 0223
West Palm Beach, Florida, United States
Local Institution - 0149
West Palm Beach, Florida, United States
Local Institution - 0029
Windermere, Florida, United States
Local Institution - 0101
Winter Park, Florida, United States
Local Institution - 0154
Winter Park, Florida, United States
Local Institution - 0105
Columbus, Georgia, United States
Local Institution - 0236
Chicago, Illinois, United States
Local Institution - 0021
Chicago, Illinois, United States
Local Institution - 0161
Elk Grove Village, Illinois, United States
Local Institution - 0003
Gurnee, Illinois, United States
Local Institution - 0145
Park Ridge, Illinois, United States
Local Institution - 0081
Springfield, Illinois, United States
Local Institution - 0235
Boston, Massachusetts, United States
Local Institution - 0025
Boston, Massachusetts, United States
Local Institution - 0015
Braintree, Massachusetts, United States
Local Institution - 0174
Foxborough, Massachusetts, United States
Local Institution - 0118
Methuen, Massachusetts, United States
Local Institution - 0040
Newton, Massachusetts, United States
Local Institution - 0120
Plymouth, Massachusetts, United States
Local Institution - 0045
Watertown, Massachusetts, United States
Local Institution - 0119
Portsmouth, New Hampshire, United States
Local Institution - 0031
Princeton, New Jersey, United States
Local Institution - 0062
Toms River, New Jersey, United States
Local Institution - 0060
Albany, New York, United States
Local Institution - 0157
Amherst, New York, United States
Local Institution - 0061
Manhasset, New York, United States