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Bioavailability of Hydroxytyrosol in Healthy Adult Humans
Sponsor: Anglia Ruskin University
Summary
Brief summary: There is current scientific interest in hydroxytyrosol due to its anti-inflammatory and antioxidant properties, efficient protection of vascular tissue and ability to neutralise free radicals via hydrogen donation. Recognised as the potent polyphenol within a commercially available olive-fruit water (OliPhenolia®), data from this research will determine the dose of OliPhenolia® required for the optimum absorption and metabolism of hydroxytyrosol. The primary aim of this research is to identify the dose of hydroxytyrosol (0.5, 1.0 or 1.5 mg∙kg-1) within OliPhenolia® that demonstrates the greatest area under the plasma concentration curve for hydroxytyrosol over a four-hour period. A secondary aim is to assess maximum concentration (CMAX) and time to maximum concentration (TMAX) of total hydroxytyrosol and secondary metabolites (Tyrosol, HT-3-glucoronide, HT-3-sulphate, 3,4-Dihydroxyphenylacetic Acid, Homovanillic Acid and Oleuropein) following consumption of 3 randomised doses of OliPhenolia® on separate occasions with healthy adult volunteers.
Official title: The Dose Response of a Commercially Available Olive Fruit Water (OliPhenolia®) on the Bioavailability of Hydroxytyrosol, and Its Metabolites, Over a Four-hour Time Period in Healthy Adult Humans.
Key Details
Gender
All
Age Range
21 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
8
Start Date
2024-02-03
Completion Date
2024-07-30
Last Updated
2026-10-20
Healthy Volunteers
Yes
Conditions
Interventions
OliPhenolia®)
Olive derived hydroxytyrosol will be ingested via a commercially available olive fruit wastewater (OliPhenolia®) in a dose relative to participant body mass. Participants will consume three doses within the entire study, one dose per visit, separated by a ≥3 day wash out period.
Locations (1)
Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University
Cambridge, United Kingdom