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Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis
Sponsor: Gilead Sciences
Summary
The goal of this study is to learn if emvistegrast (formerly GS-1427) is effective in treating participants with moderate to severe ulcerative colitis. The study will compare participants in different treatment groups treated with emvistegrast with participants treated with placebo. The primary objective of this study is to assess the efficacy of emvistegrast, compared with placebo control, in achieving clinical response at Week 12.
Official title: A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Dose-Ranging Study Evaluating the Efficacy and Safety of GS-1427 in Adult Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
228
Start Date
2024-03-27
Completion Date
2028-04
Last Updated
2026-04-09
Healthy Volunteers
No
Conditions
Interventions
emvistegrast
Administered orally
Placebo-to-match emvistegrast
Administered orally
Locations (181)
Onyx Clinical Research (Clinic Location)
Peoria, Arizona, United States
Om Research LLC
Camarillo, California, United States
VVCRD Research
Garden Grove, California, United States
310 Clinical Research
Inglewood, California, United States
US San Diego Health System
La Jolla, California, United States
Om Research LLC
Lancaster, California, United States
UCSF Benioff Children's Hospital Oakland
Oakland, California, United States
University Of California, Davis
Sacramento, California, United States
SDG Clinical Research, LLC
San Diego, California, United States
Acclaim Clinical Research
San Diego, California, United States
Peak Gastroenterology Associates
Colorado Springs, Colorado, United States
Peak Gastroenterology Associates
Colorado Springs, Colorado, United States
Gastro Florida
Clearwater, Florida, United States
Best Quality Research, Inc
Hialeah, Florida, United States
United Research Institute LLC
Hialeah, Florida, United States
University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer Center(Drug shipment)-Research Pharmacy
Miami, Florida, United States
Medical Professional Clinical Research Center, Inc.
Miami, Florida, United States
Blessed Health Care & Research, Inc
Miami, Florida, United States
Alliance Clinical Research of Tampa, LLC
New Port Richey, Florida, United States
Digestive and Liver Center of Florida, LLC
Orlando, Florida, United States
Clinical Research of Osceola
Orlando, Florida, United States
Encore Medical Research of Weston, LLC
Weston, Florida, United States
EBGS Clinical Research Center
Snellville, Georgia, United States
The University of Chicago Medical Center (Duchossois Center for Advanced Medicine)
Chicago, Illinois, United States
Onyx Clinical Research
Peoria, Illinois, United States
Robley Rex VA Medical Center
Louisville, Kentucky, United States
Louisiana Research Center, LLC
Shreveport, Louisiana, United States
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center.
Wyoming, Michigan, United States
Mayo Clinic
Rochester, Minnesota, United States
Gastroenterology Associates of North Mississippi
Oxford, Mississippi, United States
Digestive Health Specialists (Clinic Visits)
Tupelo, Mississippi, United States
St Charles Clinical Research
Weldon Spring, Missouri, United States
Tandem - Allied Clinical Research, LLC
Freehold, New Jersey, United States
N.Y. Total Medical Care, PC
Brooklyn, New York, United States
NYU Langone Long Island Clinical Research Associates
Great Neck, New York, United States
Lenox Hill Hospital
Manhasset, New York, United States
NYU Grossman School of Medicne
New York, New York, United States
Carolina Research
Greenville, North Carolina, United States
Piedmont Healthcare
Statesville, North Carolina, United States
Dayton Gastroenterology, LLC
Beavercreek, Ohio, United States
Gastro Health Research
Cincinnati, Ohio, United States
NexGen Research
Lima, Ohio, United States
Gastro Intestinal Research Institute of Northern Ohio, LLC
Westlake, Ohio, United States
Penn State University Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
Skyline gastroenterology of west Tennessee
Jackson, Tennessee, United States
Quality Medical Research
Nashville, Tennessee, United States
Vanderbilt Inflammatory Bowel Disease Clinic
Nashville, Tennessee, United States
Gastroenterology Research of San Antonio
Fredericksburg, Texas, United States
Amel Med Llc
Georgetown, Texas, United States
GI Alliance - Mansfield
Mansfield, Texas, United States
Clinical Associates in Research Therapeutics of America, LLC
San Antonio, Texas, United States
Southern Star Research Institute, LLC.
San Antonio, Texas, United States
Tyler Research Institute, LLC.
Tyler, Texas, United States
University of Virginia Medical Center
Charlottesville, Virginia, United States
Emeritas Research Group
Lansdowne Town Center, Virginia, United States
Gastroenterology Consultants of Southwest Virginia
Roanoke, Virginia, United States
Macquarie University
Sydney, New South Wales, Australia
Mater Adult Hospital - Mater Misericordiae Ltd and Mater Research Ltd
South Brisbane, Queensland, Australia
Princess Alexandra Hospital - Metro South Health
Woolloongabba, Queensland, Australia
The Queen Elizabeth Hospital
Woodville, South Australia, Australia
Monash Health - Monash Medical Centre
Clayton, Victoria, Australia
Northern Hospital - Northern Health
Epping, Victoria, Australia
Saint Vincent's Hospital Melbourne
Fitzroy, Victoria, Australia
Footscray Hospital - Westerm Health
Footscray, Victoria, Australia
Medical University Innsbruck, University Hospital for Internal Medicine I
Innsbruck, Austria
Regional Hospital Salzburg, University Clinic for Internal Medicine I
Salzburg, Austria
Medical University Vienna, Department of Internal Medicine Division Gastroenterology and Hepatology
Vienna, Austria
Imeldaziekenhuis
Bonheiden, Belgium
AZ Groeninge
Kortrijk, Belgium
Vitaz
Sint-Niklaas, Belgium
TDDA Specialty Reserach
Vaughan, Canada
PreventaMed, s.r.o.
Olomouc, Czechia
Nemocnice Slany
Slaný, Czechia
Centre Hospitalier Universitaire Grenoble Alpes(CHUGA) - Service Hepato-Gastroentérologie, 7éme unité D
La Tronche, France
CHU Nantes Gastroenterology department
Nantes, France
Hospices Civilis de Lyon - Hospital Lyon Sud Department of Gastroenterology
Pierre-Bénite, France
ARENSIA Exploratory Medicine
Tbilisi, Georgia
Universitatsklinikum Carl Gustav Carus an der TU Dresden, Medizinische Klinik und Poliklinik |
Dresden, Germany
Studiengesellschaft BSF UG
Halle, Germany
University Hospital Schleswig-Holstein, Clinic for Internal Medicine
Kiel, Germany
Ulm University Hospital, Centre for Internal Medicine I
Ulm, Germany
Queen Mary Hospital
Hong Kong, Hong Kong
Princess Margaret Hospital
Hong Kong, Hong Kong
Békés Varmegye Kozponti Korhaz, dr Rethy Pal 4. Belgyégyaszat - Gasztroenterologia
Békéscsaba, Hungary
Semmelweis Egyetem AOK
Budapest, Hungary
Semmelweis Egyetem Általanos Orvostudományi Kar
Budapest, Hungary
Clinexpert Gyógycentrum
Budapest, Hungary
Azienda Ospedaliero-Universitaria Di Bologna IRCCS
Bologna, Italy
Azienda Ospedaliera Brotzu - P.O. San Michele
Cagliari, Italy
AOU "Renato Dulbecco" - Digestive Physiopathology Unit
Catanzaro, Italy
San Raffaele Hospital IRCCS
Milan, Italy
IRCCS Ospedale Sacro Cuore Don Calabria
Negrar, Italy
Azienda Ospedale Universita di Padova
Padova, Italy
AOOR Villa Sofia- Cervello
Palermo, Italy
Campus Biomedico University Hospital Foundation
Roma, Italy
Ospedale Sandro Pertini
Roma, Italy
IRCCS Policlinico San Donato
San Donato Milanese, Italy
Ospedale Casa Sollievo della Sofferenza IRCCS, Opera di San Pio da Pietrelcina
San Giovanni Rotondo, Italy
Azienda Ospedaliera Ordine Mauriziano di Torino
Torino, Italy