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Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)
Sponsor: Alexion Pharmaceuticals, Inc.
Summary
The primary objective of this study to evaluate efficacy of ravulizumab compared with placebo on proteinuria reduction and change in eGFR in adult participants with IgAN who are at risk of disease progression.
Official title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Participants With Immunoglobulin A Nephropathy (IgAN)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
584
Start Date
2024-03-29
Completion Date
2030-07-18
Last Updated
2026-10-02
Healthy Volunteers
No
Conditions
Interventions
Ravulizumab
Participants will receive ravulizumab via weight-based intravenous (IV) infusion.
Placebo
Participants will receive placebo via weight-based IV infusion.
Locations (246)
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Alabaster, Alabama, United States
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Phoenix, Arizona, United States
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Los Angeles, California, United States
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Los Angeles, California, United States
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Los Angeles, California, United States
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Orange, California, United States
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San Bernardino, California, United States
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San Diego, California, United States
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San Francisco, California, United States
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Stanford, California, United States
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Torrance, California, United States
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Valencia, California, United States
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Bay Pines, Florida, United States
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Miami, Florida, United States
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Orlando, Florida, United States
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Acworth, Georgia, United States
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Atlanta, Georgia, United States
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Lawrenceville, Georgia, United States
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New Orleans, Louisiana, United States
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Boston, Massachusetts, United States
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Boston, Massachusetts, United States
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Boston, Massachusetts, United States
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Worcester, Massachusetts, United States
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Minneapolis, Minnesota, United States
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Minneapolis, Minnesota, United States
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Kansas City, Missouri, United States
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North Las Vegas, Nevada, United States
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Albany, New York, United States
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New York, New York, United States
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The Bronx, New York, United States
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Columbus, Ohio, United States
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Knoxville, Tennessee, United States
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Arlington, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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San Antonio, Texas, United States
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Shenandoah, Texas, United States
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Charlottesville, Virginia, United States
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Milwaukee, Wisconsin, United States
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Ciudad de Buenos Aires, Argentina
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Ciudad de Buenos Aires, Argentina
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Córdoba, Argentina
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La Plata, Argentina
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Rosario, Argentina
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Canberra, Australia
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Clayton, Australia
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Concord, Australia
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Herston, Australia
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Liverpool, Australia
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Perth, Australia
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Southport, Australia
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St Albans, Australia
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Graz, Austria
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Innsbruck, Austria
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Linz, Austria
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Brussels, Belgium
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Edegem, Belgium
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Leuven, Belgium
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Belo Horizonte, Brazil
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Belo Horizonte, Brazil
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Botucatu, Brazil
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Curitiba, Brazil
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Fortaleza, Brazil
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Recife, Brazil
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Ribeirão Preto, Brazil
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São José do Rio Preto, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Winnipeg, Manitoba, Canada
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Brampton, Ontario, Canada
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London, Ontario, Canada
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Toronto, Ontario, Canada
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Araucania, Chile
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Providencia, Chile
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Santiago, Chile
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Santiago, Chile
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Valdivia, Chile
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Baotou, China
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Beijing, China
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Beijing, China
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Beijing, China
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Changsha, China
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Changzhou, China
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Chengdu, China
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Chengdu, China
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Chongqing, China
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Guangzhou, China
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Hangzhou, China
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Jinan, China
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Jinhua, China
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Lanzhou, China
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Luoyang, China
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Nanchang, China
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Nanchang, China
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Nanjing, China
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Nanjing, China
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Nanjing, China
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Ningbo, China
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Qingdao, China
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Shanghai, China