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Phase 3 Study of Plozasiran in Adults With Hypertriglyceridemia
Sponsor: Arrowhead Pharmaceuticals
Summary
This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with hypertriglyceridemia (HTG). After providing informed consent eligible participants will be randomized to receive 4 doses (once every 3 months) of plozasiran or placebo and be evaluated for efficacy and safety.
Official title: Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults With Hypertriglyceridemia
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1456
Start Date
2024-05-21
Completion Date
2026-09-08
Last Updated
2026-09-25
Healthy Volunteers
No
Conditions
Interventions
Plozasiran Injection
ARO-APOC3 Injection
Placebo
sterile normal saline (0.9% NaCl)
Locations (235)
Research Site 1
Birmingham, Alabama, United States
Research Site 2
Mobile, Alabama, United States
Research Site 3
Beverly Hills, California, United States
Research Site 4
Canoga Park, California, United States
Research Site 5
Garden Grove, California, United States
Research Site 6
Huntington Beach, California, United States
Research Site 7
Lake Forest, California, United States
Research Site 8
Lincoln, California, United States
Research Site 9
Long Beach, California, United States
Research Site 10
Montclair, California, United States
Research Site 11
Oxnard, California, United States
Research Site 12
Redding, California, United States
Research Site 13
Van Nuys, California, United States
Research Site 14
Colorado Springs, Colorado, United States
Research Site 15
Clearwater, Florida, United States
Research Site 16
Hialeah, Florida, United States
Research Site 17
Lake City, Florida, United States
Research Site 18
Miami Lakes, Florida, United States
Research Site 19
Mt. Dora, Florida, United States
Research Site 20
North Miami Beach, Florida, United States
Research Site 21
Orlando, Florida, United States
Research Site 22
Pensacola, Florida, United States
Research Site 23
Sarasota, Florida, United States
Research Site 24
Tamarac, Florida, United States
Research Site 25
Lawrenceville, Georgia, United States
Research Site 26
Macon, Georgia, United States
Research Site 27
Savannah, Georgia, United States
Research Site 28
Sugar Hill, Georgia, United States
Research Site 29
Park Ridge, Illinois, United States
Research Site 30
Elkhart, Indiana, United States
Research Site 31
Indianapolis, Indiana, United States
Research Site 32
South Bend, Indiana, United States
Research Site 33
Overland Park, Kansas, United States
Research Site 34
Topeka, Kansas, United States
Research Site 35
Louisville, Kentucky, United States
Research Site 36
Zachary, Louisiana, United States
Research Site 37
Annapolis, Maryland, United States
Research Site 38
Baltimore, Maryland, United States
Research Site 39
Flint, Michigan, United States
Research Site 40
Minneapolis, Minnesota, United States
Research Site 41
Olive Branch, Mississippi, United States
Research Site 42
Jefferson City, Missouri, United States
Research Site 43
St Louis, Missouri, United States
Research Site 44
Norfolk, Nebraska, United States
Research Site 46
Omaha, Nebraska, United States
Research Site 45
Omaha, Nebraska, United States
Research Site 47
Las Vegas, Nevada, United States
Research Site 48
Summit, New Jersey, United States
Research Site 52
New York, New York, United States
Research Site 51
New York, New York, United States
Research Site 53
Riverhead, New York, United States
Research Site 54
Rochester, New York, United States
Research Site 49
The Bronx, New York, United States
Research Site 50
The Bronx, New York, United States
Research Site 55
Vestal, New York, United States
Research Site 56
Asheboro, North Carolina, United States
Research Site 57
Morehead City, North Carolina, United States
Research Site 58
Wilmington, North Carolina, United States
Research Site 59
Winston-Salem, North Carolina, United States
Research Site 60
Beavercreek, Ohio, United States
Research Site 61
Cincinnati, Ohio, United States
Research Site 63
Columbus, Ohio, United States
Research Site 62
Columbus, Ohio, United States
Research Site 64
Norman, Oklahoma, United States
Research Site 66
Oklahoma City, Oklahoma, United States
Research Site 65
Oklahoma City, Oklahoma, United States
Research Site 67
Horsham, Pennsylvania, United States
Research Site 68
Newport, Pennsylvania, United States
Research Site 69
Newport, Pennsylvania, United States
Research Site 70
Philadelphia, Pennsylvania, United States
Research Site 71
Wilkes-Barre, Pennsylvania, United States
Research Site 72
Fort Mill, South Carolina, United States
Research Site 73
Greenville, South Carolina, United States
Research Site 74
Chattanooga, Tennessee, United States
Research Site 75
Powell, Tennessee, United States
Research Site 76
El Paso, Texas, United States
Research Site 77
Fort Worth, Texas, United States
Research Site 86
Houston, Texas, United States
Research Site 84
Houston, Texas, United States
Research Site 85
Houston, Texas, United States
Research Site 78
Houston, Texas, United States
Research Site 80
Houston, Texas, United States
Research Site 83
Houston, Texas, United States
Research Site 82
Houston, Texas, United States
Research Site 79
Houston, Texas, United States
Research Site 81
Houston, Texas, United States
Research Site 87
Laredo, Texas, United States
Research Site 88
Missouri City, Texas, United States
Research Site 89
Plano, Texas, United States
Research Site 90
San Antonio, Texas, United States
Research Site 91
Sugar Land, Texas, United States
Research Site 92
Tomball, Texas, United States
Research Site 93
Victoria, Texas, United States
Research Site 94
Bountiful, Utah, United States
Research Site 95
St. George, Utah, United States
Research Site 96
Manassas, Virginia, United States
Research Site 97
Seattle, Washington, United States
Research Site 102
CABA, Buenos Aires, Argentina
Research Site 100
CABA, Buenos Aires, Argentina
Research Site 103
Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina