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Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
Sponsor: AstraZeneca
Summary
The purpose of this study is to evaluate efficacy and safety of Dato-DXd in combination with rilvegostomig or rilvegostomig monotherapy compared with pembrolizumab monotherapy as a first line therapy in participants with locally advanced or metastatic non-squamous NSCLC with high PD-L1 expression (TC ≥ 50%) and without actionable genomic alterations.
Official title: A Phase III, Randomised, Open-label, Global Study of Datopotamab Deruxtecan (Dato-DXd) in Combination With Rilvegostomig or Rilvegostomig Monotherapy Versus Pembrolizumab Monotherapy for the First-line Treatment of Participants With Locally-advanced or Metastatic Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations (TROPION-Lung10)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
675
Start Date
2024-04-11
Completion Date
2029-12-28
Last Updated
2026-10-28
Healthy Volunteers
No
Conditions
Interventions
Datopotamab Deruxtecan
Datopotamab Deruxtecan IV (intravenous)
Rilvegostomig
Rilvegostomig IV (intravenous)
Pembrolizumab
Pembrolizumab IV (intravenous)
Locations (290)
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Anchorage, Alaska, United States
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Tucson, Arizona, United States
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Little Rock, Arkansas, United States
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Springdale, Arkansas, United States
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Anaheim, California, United States
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Beverly Hills, California, United States
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Fountain Valley, California, United States
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Newport Beach, California, United States
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Clermont, Florida, United States
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Gainesville, Florida, United States
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Miami Beach, Florida, United States
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Orange City, Florida, United States
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Orlando, Florida, United States
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Orlando, Florida, United States
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West Palm Beach, Florida, United States
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Atlanta, Georgia, United States
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Atlanta, Georgia, United States
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Atlanta, Georgia, United States
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Atlanta, Georgia, United States
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Hinsdale, Illinois, United States
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Noblesville, Indiana, United States
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Paducah, Kentucky, United States
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Annapolis, Maryland, United States
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Boston, Massachusetts, United States
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Boston, Massachusetts, United States
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Dearborn, Michigan, United States
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Farmington Hills, Michigan, United States
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Grand Rapids, Michigan, United States
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Traverse City, Michigan, United States
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Hattiesburg, Mississippi, United States
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Kansas City, Missouri, United States
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Bozeman, Montana, United States
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Grand Island, Nebraska, United States
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Omaha, Nebraska, United States
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Las Vegas, Nevada, United States
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Reno, Nevada, United States
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Voorhees Township, New Jersey, United States
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Stony Brook, New York, United States
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Greenville, North Carolina, United States
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Salisbury, North Carolina, United States
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Cincinnati, Ohio, United States
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Columbus, Ohio, United States
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Maumee, Ohio, United States
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Toledo, Ohio, United States
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Portland, Oregon, United States
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Greenville, South Carolina, United States
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Sioux Falls, South Dakota, United States
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Chattanooga, Tennessee, United States
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Knoxville, Tennessee, United States
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Fort Worth, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Kingwood, Texas, United States
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Odessa, Texas, United States
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Fort Belvoir, Virginia, United States
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Leesburg, Virginia, United States
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Midlothian, Virginia, United States
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Richmond, Virginia, United States
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Tacoma, Washington, United States
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Vancouver, Washington, United States
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Wenatchee, Washington, United States
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Appleton, Wisconsin, United States
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Birtinya, Australia
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Blacktown, Australia
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Clayton, Australia
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Gosford, Australia
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Melbourne, Australia
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South Brisbane, Australia
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Wodonga, Australia
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Innsbruck, Austria
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Krems, Austria
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Linz, Austria
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Rankweil, Austria
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Vienna, Austria
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Vienna, Austria
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Wels, Austria
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Anderlecht, Belgium
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Bruges, Belgium
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Hasselt, Belgium
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La Louvière, Belgium
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Liège, Belgium
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Barretos, Brazil
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Curitiba, Brazil
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Florianópolis, Brazil
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Ipatinga, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Rio de Janeiro, Brazil
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Santa Maria, Brazil
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São Paulo, Brazil
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Taubaté, Brazil
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Vancouver, British Columbia, Canada
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Winnipeg, Manitoba, Canada
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St. John's, Newfoundland and Labrador, Canada
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London, Ontario, Canada
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Newmarket, Ontario, Canada
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Oshawa, Ontario, Canada
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Toronto, Ontario, Canada
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Lévis, Quebec, Canada