Clinical Research Directory

Inclusion Criteria: 1. Age 18-80 years old. 2. Acute ischemic stroke confirmed by CT or MRI at 14 days after onset. 3. Pre-stroke modified Rankin scale (mRS) score≤1. 4. 4≤NIHSS score≤ 25, 1a≤1, NIHSS5a/5b/6a/6b≥2 at least. 5. Moderate or severe motor dysfunction (Fugl-Meyer motor score \< 80). 6. Written informed consent from patients or their legally authorized representatives. Exclusion Criteria: 1. TMS contraindications include metallic foreign bodies in the head, pacemaker, implantable drug pumps, cochlear implants, etc. 2. Epilepsy or history of epilepsy, intracranial hypertension, tumor and other serious neurological disorders; 3. Midline displacement and brain parenchymal mass effect seen in head CT and other images; 4. Head CT or MRI showed bilateral acute cerebral infarction; 5. Evidence of acute intracranial hemorrhage; 6. A history of congenital or acquired hemorrhagic disease, coagulation factor deficiency, or thrombocytopenia disease; 7. After blood pressure control, the systolic blood pressure was still ≥180 mmHg or the diastolic blood pressure was ≥110 mmHg; 8. Patients during pregnancy or lactation and within 90 days of planned pregnancy; 9. Patients with severe mental disorders or dementia who can not cooperate with informed consent and follow-up; 10. Patients with malignancy or severe systemic disease and expected survival of less than 90 days; 11. Participants in other clinical intervention studies within 30 days before randomization or who were participating in other clinical intervention studies. 12. Patients with ataxia (NIHSS 7 ≥ 1) and aphasia (NIHSS 9 ≥ 2).