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Investigating Near-Threshold Perception During Anesthetic Sedation
Sponsor: University of Michigan
Summary
The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia. Propofol is FDA approved for use in patients undergoing an anesthetic for medical treatment but is not approved for use in healthy volunteers.
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2024-05-10
Completion Date
2025-11-02
Last Updated
2026-10-30
Healthy Volunteers
Yes
Conditions
Interventions
Functional Magnetic Resonance Imaging (fMRI) with propofol
Three 16-min sessions in wakeful baseline, light sedation, and recovery will be conducted (Fig. 2). Light sedation will be achieved by IV infusion of propofol to achieve effect-site concentrations of 1.0 μg/ml. Infusion rate will be manually controlled. An initial bolus dose (525 µg/kg) and subsequent infusion rate (82 µg/kg/min) for each participant
Locations (1)
University of Michigan
Ann Arbor, Michigan, United States