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Pericardiotomy in Cardiac Surgery
Sponsor: Population Health Research Institute
Summary
PRINCE is an international, multicentre, randomized controlled trial of posterior pericardiotomy in patients without a history of atrial fibrillation (AF) or flutter undergoing cardiac surgery.
Official title: Pericardiotomy in Cardiac Surgery Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1400
Start Date
2024-10-21
Completion Date
2031-09-01
Last Updated
2026-10-21
Healthy Volunteers
No
Interventions
Left Posterior Pericardiotomy
The surgeon will perform a left posterior pericardiotomy while the patient is on cardiopulmonary bypass. A soft channel drain will be put into place at an angle directed toward the posterior pericardium. The surgeon will grasp the pericardium and use cautery to make a 4- to 5-cm opening between the left inferior pulmonary vein and the diaphragm. The previously prepared channel drain is cut to the desired length and placed through the pericardiotomy along the diaphragm and into the pleural space.
Locations (19)
University of Louisville
Louisville, Kentucky, United States
Weill Cornell Medicine
New York, New York, United States
Baylor College of Medicine
Houston, Texas, United States
Medical University Vienna
Vienna, State of Vienna, Austria
Medical University of Innsbruck
Innsbruck, Tyrol, Austria
Nova Scotia Health Authority - Halifax Infirmary
Halifax, Nova Scotia, Canada
Hamilton Health Sciences
Hamilton, Ontario, Canada
St. Michael's Hospital
Toronto, Ontario, Canada
Montreal Heart Institute
Montreal, Quebec, Canada
(CHUM) Centre hospitalier de l'Université de Montréal
Montreal, Quebec, Canada
McGill University Health Centre - Royal Victoria Hospital
Montreal, Quebec, Canada
Hôpital du Sacré-Cœur-de-Montréal
Montreal, Quebec, Canada
Policlinico Foggia
Foggia, Foggia, Italy
University of Foggia, Policlinico Foggia
Foggia, Foggia, Italy
IRCSS Policlinico San Donato
San Donato Milanese, Milano, Italy
Maria Pia Hospital
Turin, Turin, Italy
San Bortolo Hospital
Vicenza, Vincenza, Italy
Hospital Universitario del Vinalopo
Alicante, Alicante, Spain
Hospital Clinico San Carlos
Madrid, Madrid, Spain