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Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients
Sponsor: PrECOG, LLC.
Summary
The goal of the study is to collect data on patients treated outside of a clinical trial (in routine clinical practice) with standard of care osimertinib with or without chemotherapy in Epidermal Growth Factor Receptor (EGFR)-mutant Non-Small Cell Lung Cancer (NSCLC) to better understand the safety and effectiveness of these standard of care regimens.
Official title: Prospective Non-Interventional Study Comparing Standard of Care Osimertinib +/- Chemotherapy for EGFR-Mutated Non-Small Cell Lung Cancer (NSCLC) Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2024-09-17
Completion Date
2029-08
Last Updated
2026-09-09
Healthy Volunteers
No
Conditions
Interventions
Osimertinib
Single agent Osimertinib by mouth once daily. Dosing and administration of osimertinib will be administered as per routine standard of care per the package insert or per institutional guidelines.
Osimertinib + Chemotherapy
Osimertinib by mouth once daily + Chemotherapy. Chemotherapy choice will be per treating physician. Dosing and administration of osimertinib +/- chemotherapy agents will be administered as per routine standard of care per the package insert or per institutional guidelines.
Locations (146)
University of Alabama at Birmingham
Birmingham, Alabama, United States
Mercy Clinic Fort Smith Communities
Fort Smith, Arkansas, United States
Mercy Research
Fort Smith, Arkansas, United States
Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, United States
Stanford Cancer Center Emeryville
Emeryville, California, United States
Stanford Cancer Institute Palo Alto
Palo Alto, California, United States
Stanford Cancer Center South Bay
San Jose, California, United States
John Muir Health
Walnut Creek, California, United States
Bayhealth
Dover, Delaware, United States
Satellite of Bayhealth Sussex
Milford, Delaware, United States
Sibley Johns Hopkins University
Washington D.C., District of Columbia, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: Liberty County Cancer Care
Hinesville, Georgia, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: Regional Cancer Care
Jesup, Georgia, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, United States
Advocate Good Shepherd Hospital
Barrington, Illinois, United States
Northwestern University
Chicago, Illinois, United States
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, United States
Advocate Illinois Masonic Medical Center
Chicago, Illinois, United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, United States
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois, United States
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois, United States
Advocate South Suburban Hospital
Hazel Crest, Illinois, United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, United States
Carle Cancer Institute Normal
Normal, Illinois, United States
Advocate Christ Medical Center
Oak Lawn, Illinois, United States
Northwestern Medicine Orland Park
Orland Park, Illinois, United States
Advocate Lutheran General Hospital
Park Ridge, Illinois, United States
Carle Founation Hospital
Urbana, Illinois, United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States
University of Maryland Greenebaum Comprehensive Cancer Center
Baltimore, Maryland, United States
Greater Baltimore Medical Center
Baltimore, Maryland, United States
Tufts Medical Center
Boston, Massachusetts, United States
Lowell General Hosptial
Lowell, Massachusetts, United States
Tufts Medical Center Cancer Center Stoneham
Stoneham, Massachusetts, United States
Minnesota Oncology - Burnsville
Burnsville, Minnesota, United States
Cambridge Medical Center
Cambridge, Minnesota, United States
Mercy Hospital
Coon Rapids, Minnesota, United States
Fairview Southdale Hospital
Edina, Minnesota, United States
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, United States
Saint John's Hospital - Healtheast
Maplewood, Minnesota, United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota, United States
Hennepin County Medical Center
Minneapolis, Minnesota, United States
Health Partners Inc.
Minneapolis, Minnesota, United States
Monticello Cancer Center
Monticello, Minnesota, United States
New Ulm Medical Center
New Ulm, Minnesota, United States
Fairview Northland Medical Center
Princeton, Minnesota, United States
North Memorial Medical Health Center
Robbinsdale, Minnesota, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, United States
Metro MN
Saint Louis Park, Minnesota, United States
Regions Hospital
Saint Paul, Minnesota, United States
United Hospital
Saint Paul, Minnesota, United States
Saint Francis Regional Medical Center
Shakopee, Minnesota, United States
Lakeview Hospital
Stillwater, Minnesota, United States
Ridgeview Medical Center
Waconia, Minnesota, United States
Rice Memorial Hospital
Willmar, Minnesota, United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, United States
Fairview Lakes Medical Center
Wyoming, Minnesota, United States
Baptist Memorial Hospital and Cancer Center - Golden Triangle
Columbus, Mississippi, United States
Baptist Cancer Center - Grenada
Grenada, Mississippi, United States
Jackson Oncology Associates PLLC
Jackson, Mississippi, United States
Mississippi Baptist Medical Center
Jackson, Mississippi, United States
Baptist Memorial Hospital and Cancer Center - Union
New Albany, Mississippi, United States
Baptist Memorial Hospital and Cancer Center - Oxford
Oxford, Mississippi, United States
Baptist Memorial Hospital and Cancer Center - Desoto
Southhaven, Mississippi, United States
Mercy Clinic Joplin, LLC
Joplin, Missouri, United States
Mercy Clinic Cancer and Hematology
Rolla, Missouri, United States
Mercy Clinic Springfield Communities
Springfield, Missouri, United States
Mercy Clinic East Communities
St Louis, Missouri, United States
Mercy Clinic East Communities
St Louis, Missouri, United States
Virtua Samson Cancer Center
Moorestown, New Jersey, United States
Atlantic Health Cancer Consortium Community Oncology Research Program
Morristown, New Jersey, United States
Morristown Medical Center
Morristown, New Jersey, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States
The Valley Hospital - Luckow Pavilion
Paramus, New Jersey, United States
Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey, United States
Overlook Medical Center
Summit, New Jersey, United States
Virtua Voorhees
Voorhees Township, New Jersey, United States
The Cancer Institute at St. Francis Hospital
East Hills, New York, United States
Montefiore
New York, New York, United States
SUNY Upstate Medical University
Syracuse, New York, United States
Montefiore Medical Center-Einstein Campus
The Bronx, New York, United States
Good Samaritan University Hospital
West Islip, New York, United States
UNC Pardee Cancer Center
Hendersonville, North Carolina, United States
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina, United States
Aultman
Canton, Ohio, United States
Miami Valley Hospital South
Centerville, Ohio, United States
Miami Valley Hospital North
Englewood, Ohio, United States
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, United States
Miami Valley Cancer Care and Infusion
Greenville, Ohio, United States
Upper Valley Medical Center
Troy, Ohio, United States
Mercy Clinic Oklahoma Communities, Inc.
Oklahoma City, Oklahoma, United States
Geisinger Medical Center
Danville, Pennsylvania, United States
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania, United States
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, United States
Lewistown Hospital
Lewistown, Pennsylvania, United States
Lankenau Medical Center
Paoli, Pennsylvania, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States