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A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
Sponsor: Regeneron Pharmaceuticals
Summary
This study is researching experimental (study) drugs called pozelimab and cemdisiran. The study is focused on participants who have Geographic Atrophy (GA) caused by Age-related Macular Degeneration (AMD). Geographic atrophy is a medical term that refers to later-stage cases of AMD which is an eye condition affecting central vision (what one sees straight ahead). The purpose of this study is to evaluate the progression rate of Geographic Atrophy in eyes of patients treated with cemdisiran alone or in combination with pozelimab compared to those treated with placebo. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug(s) * How much study drug(s) are in the blood at different times * Whether the body makes antibodies against the study drug(s) (which could make the study drug(s) less effective or could lead to side effects)
Official title: A Multicenter, Randomized, Double-Masked, Placebo-Controlled Phase 3 Study of the Efficacy, Safety, and Tolerability of Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
Key Details
Gender
All
Age Range
50 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
975
Start Date
2024-10-30
Completion Date
2033-04-09
Last Updated
2026-10-13
Healthy Volunteers
No
Interventions
Pozelimab
Subcutaneous (SC) injection
Cemdisiran
SC injection
Placebo
SC injection
Locations (231)
Barnet Dulaney Perkins Eye Center-Ophthamalogy
Chandler, Arizona, United States
Barnet Dulaney Perkins Eye Center
Phoenix, Arizona, United States
Associated Retina Consultants
Phoenix, Arizona, United States
Retinal Research Institute
Phoenix, Arizona, United States
Retina Macula Institute of Arizona
Scottsdale, Arizona, United States
Retina Associates of Tuscan
Tucson, Arizona, United States
Retina Partners of Northwest Arkansas, PLLC
Springdale, Arkansas, United States
Retina Vitreous Associates Medical Group
Beverly Hills, California, United States
Retina Specialists of Beverly Hills- Department of Ophthalmology
Beverly Hills, California, United States
The Retina Partners
Encino, California, United States
Eye Medical Center of Fresno
Fresno, California, United States
Retina Consultants of Orange County
Fullerton, California, United States
Salehi Retina Institute dba Retina Associates of Southern California
Huntington Beach, California, United States
University of California Irvine
Irvine, California, United States
University of California San Diego, Jacobs Retina Center
La Jolla, California, United States
South Coast Retina Center
Long Beach, California, United States
American Institute of Research
Los Angeles, California, United States
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States
Jules Stein Eye Institute in David Geffen School of Medicine at UCLA
Los Angeles, California, United States
Retinal Consultants Medical Group Inc Modesto
Modesto, California, United States
Northern California Retina Vitreous Associates Medical Group, Inc.
Mountain View, California, United States
California Retina Consultants
Oxnard, California, United States
Desert Retina Consultants
Palm Desert, California, United States
California Eye Specialists Medical Group Inc.
Pasadena, California, United States
Retina Consultants San Diego
Poway, California, United States
California Eye Specialists Medical Group, Inc.
Redlands, California, United States
Optic Eye Care
Rowland Heights, California, United States
UC Davis Health Eye Center
Sacramento, California, United States
Vrmg Inc
Sacramento, California, United States
Retinal Consultants Medical Group (RCMG) - Greenback Lane Retina Center
Sacramento, California, United States
West Coast Retina Medical Group, Inc.
San Francisco, California, United States
Orange County Retina Medical Group
Santa Ana, California, United States
Macula Retina Vitreous Research Institute
Torrance, California, United States
University of Colorado
Aurora, Colorado, United States
Retina Consultants of Southern Colorado
Colorado Springs, Colorado, United States
Retina Specialists of Colorado - Denver
Denver, Colorado, United States
Southwest Retina Research Center
Durango, Colorado, United States
Colorado Retina - Lakewood
Lakewood, Colorado, United States
Eye care Center of Northern Colorado doing business as Advanced Vision Research Institute
Longmont, Colorado, United States
Retina Consultants - Manchester
Manchester, Connecticut, United States
Retina Group of New England
Waterford, Connecticut, United States
Advanced Retina Institute-Ophthalmology
Bonita Springs, Florida, United States
Advanced Research
Coral Springs, Florida, United States
Retina Group of Florida
Fort Lauderdale, Florida, United States
National Ophthalmic Research Institute
Fort Myers, Florida, United States
ClearVista Clinical Research, Retina Center Tampa Bay
Hudson, Florida, United States
Florida Retina Institute, Jacksonville Perimeter Park- Ophthalmology
Jacksonville, Florida, United States
Florida Retina Consultants
Lakeland, Florida, United States
Bascom Palmer Eye Institute
Naples, Florida, United States
Florida Retina Institute - Orlando
Orlando, Florida, United States
Retina Care Specialists
Palm Beach Gardens, Florida, United States
Eye Associates of Pinellas
Pinellas Park, Florida, United States
Retina Group of Florida, RAS-Sarasota Retina Center-Ophthalmology
Sarasota, Florida, United States
Retina Vitreous Associates of Florida Saint Petersburg
St. Petersburg, Florida, United States
University of South Florida Ophthalmology
Tampa, Florida, United States
Center for Retina and Macular Disease
Winter Haven, Florida, United States
Southeast Retina Center
Augusta, Georgia, United States
Georgia Retina - Marietta
Marietta, Georgia, United States
University of Illinois at Chicago
Chicago, Illinois, United States
Retinal Vitreal Consultants
Chicago, Illinois, United States
The University of Chicago
Chicago, Illinois, United States
University Retina and Macula Associates PC - Lemont
Lemont, Illinois, United States
Illinois Retina Associates
Oak Park, Illinois, United States
Springfield Clinic Main Campus East
Springfield, Illinois, United States
Midwest Eye Institute
Carmel, Indiana, United States
Retina Associates, LLC
Lenexa, Kansas, United States
University of Louisville
Louisville, Kentucky, United States
Retina Associate New Orleans
Metairie, Louisiana, United States
Ross Davis Retina
Metairie, Louisiana, United States
Ochsner Health
New Orleans, Louisiana, United States
Eye Assoc. of NE LA dba Haik Humble Eye Ctr
West Monroe, Louisiana, United States
Eye Associates of Northeast Louisiana dba Haik Humble Eye Center
West Monroe, Louisiana, United States
The Retina Care Center
Baltimore, Maryland, United States
The Retina Group of Washington
Chevy Chase, Maryland, United States
Cumberland Valley Retina Consultants-Ophthalmology
Hagerstown, Maryland, United States
Mid Atlantic Retina Specialist
Hagerstown, Maryland, United States
Massachusetts Eye And Ear Infirmary
Boston, Massachusetts, United States
Opthalmic Consultants of Boston
Boston, Massachusetts, United States
New England Retina Consultants, PC
Springfield, Massachusetts, United States
Massachusetts Eye Research and Surgery Institution (MERSI)
Waltham, Massachusetts, United States
Vitreo-Retinal Associates PC
Worcester, Massachusetts, United States
Retina Associates of Michigan
Grand Blanc, Michigan, United States
Mississippi Retina Associates
Madison, Mississippi, United States
Deep Blue Retina Clinical Research PLLC
Southaven, Mississippi, United States
Retina Research Institute, LLC
St Louis, Missouri, United States
Nashua Eye Associates
Nashua, New Hampshire, United States
Mid Atlantic Retina - Cherry Hill
Cherry Hill, New Jersey, United States
New Jersey Retina
Teaneck, New Jersey, United States
New Jersey Retina
Toms River, New Jersey, United States
Vision Research Center at Eye Associates of New Mexico
Albuquerque, New Mexico, United States
University of New Mexico, HSC
Albuquerque, New Mexico, United States
Sight MD
Brentwood, New York, United States
Retina Vitreous Surgeons of Central New York, PC
Liverpool, New York, United States
MaculaCare, PLLC
New York, New York, United States
New York Ear & Eye- East 85th
New York, New York, United States
Northwell Health- Manhattan, Ear, Eye and Throat Hospital- Ophthalmology
New York, New York, United States
Retina Associates of New York, Upper East Side
New York, New York, United States
Seeta Eye center
Poughkeepsie, New York, United States
Western Carolina Retinal Associates
Asheville, North Carolina, United States
NC Retina Associates
Cary, North Carolina, United States