Clinical Research Directory
Browse clinical research sites, groups, and studies.
Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
Sponsor: AbbVie
Summary
Crohn's disease (CD) is a long-lasting disease that causes severe inflammation (redness, swelling), in the digestive tract, most frequently affecting the bowels. It can cause many different symptoms including belly pain, diarrhea, tiredness, and weight loss. Treatments are available but do not work the same for all patients or may stop working over time. This study will evaluate the effectiveness and adverse events of targeted therapies (TaTs) for adult participants with moderate to severe CD. The medicines assessed in this study are risankizumab, trosunilimab, lutikizumab, and ABBV-8736. When participants join the study, they will be randomized into available study treatment groups. Adult participants with CD will be enrolled. Around 590 participants will be enrolled in the study at approximately 300 sites worldwide. Risankizumab and trosunilimab are given as an injection under the skin or as an infusion into the vein. Lutikizumab is given as an injection under the skin. ABBV-8736 is given as an infusion into the vein. There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, endoscopies, checking for side effects and completing questionnaires and a daily diary.
Official title: A Phase 2a Multicenter, Randomized, Platform Study of Targeted Therapies for the Treatment of Adult Subjects With Moderate to Severe Crohn's Disease
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
590
Start Date
2024-09-04
Completion Date
2030-01
Last Updated
2026-09-25
Healthy Volunteers
No
Conditions
Interventions
Risankizumab
Subcutaneous Injection
Lutikizumab
Subcutaneous Injection
Trosunilimab
Intravenous Infusion
Risankizumab
Intravenous Infusion
Trosunilimab
Subcutaneous Injection
ABBV-8736
Intravenous Infusion
Locations (255)
Digestive Health Specialists /ID# 266216
Dothan, Alabama, United States
East View Medical Research /ID# 270377
Mobile, Alabama, United States
Southern California Res. Ctr /ID# 265549
Coronado, California, United States
UC San Diego Health System /ID# 265565
La Jolla, California, United States
uc davis medical center - patient support services building /ID# 265554
Sacramento, California, United States
Clinical Applications Laboratories - San Diego - 3rd Avenue /ID# 267391
San Diego, California, United States
Peak Gastroenterology Associates - Colorado Springs - North Cascade Avenue /ID# 265557
Colorado Springs, Colorado, United States
Danbury Hospital, Western Connecticut Health Network /ID# 265556
Danbury, Connecticut, United States
Yale University School of Medicine /ID# 266786
New Haven, Connecticut, United States
Novum Research /ID# 278128
Clermont, Florida, United States
University of Florida College of Medicine /ID# 266930
Gainesville, Florida, United States
Nature Coast Clinical Research - Inverness /ID# 265874
Inverness, Florida, United States
Atlantic Medical Research /ID# 266207
Margate, Florida, United States
A Plus Research /ID# 265878
Miami, Florida, United States
Sanchez Clinical Research /ID# 265887
Miami, Florida, United States
Advanced Research Institute, Inc /ID# 265548
New Port Richey, Florida, United States
Hillcrest Medical Research, LLC /ID# 267237
Orange City, Florida, United States
Endoscopic Research, Inc. /ID# 267211
Orlando, Florida, United States
Gcp Clinical Research /ID# 278126
Tampa, Florida, United States
AdventHealth Medical Group - Tampa - Bruce B Downs Boulevard /ID# 265538
Tampa, Florida, United States
Florida Medical Clinic - Zephyrhills /ID# 267392
Zephyrhills, Florida, United States
Gastroenterology Associates of Central Georgia /ID# 265547
Macon, Georgia, United States
Treasure Valley Medical Research /ID# 267114
Boise, Idaho, United States
University of Chicago Medical Center /ID# 267400
Chicago, Illinois, United States
OSF St. Francis Medical Center /ID# 266973
Peoria, Illinois, United States
Springfield Clinic Main Campus /ID# 267434
Springfield, Illinois, United States
Indiana University Health University Hospital /ID# 278129
Indianapolis, Indiana, United States
University of Kentucky Chandler Medical Center /ID# 265564
Lexington, Kentucky, United States
Metropolitan Gastroenterology Group - Chevy Chase /ID# 265877
Chevy Chase, Maryland, United States
Velocity Clinical Research - Rockville /ID# 267712
Rockville, Maryland, United States
Lucida Clinical Trials /ID# 266548
New Bedford, Massachusetts, United States
Henry Ford Medical Center - Columbus /ID# 266503
Novi, Michigan, United States
Mayo Clinic-Rochester /ID# 265550
Rochester, Minnesota, United States
GI Associates Research, LLC /ID# 267433
Columbia, Missouri, United States
Bvl Research /ID# 265870
Liberty, Missouri, United States
Washington University /ID# 266938
St Louis, Missouri, United States
Vector Clinical Trials /ID# 265561
Las Vegas, Nevada, United States
Nyu Langone Long Island Clinical Research Associates - Lake Success /ID# 265566
Lake Success, New York, United States
Icahn School of Medicine at Mount Sinai /ID# 266857
New York, New York, United States
Northwell Health-Lenox Hill Hospital /ID# 265527
New York, New York, United States
Care Access - Yonkers /ID# 266781
Yonkers, New York, United States
Digestive Health Partners - Biltmore Office /ID# 265539
Asheville, North Carolina, United States
University of Cincinnati /ID# 265589
Cincinnati, Ohio, United States
The Ohio State University /ID# 265577
Columbus, Ohio, United States
Digestive Disease Specialists - Oklahoma /ID# 265901
Oklahoma City, Oklahoma, United States
Penn State Health Milton South Hershey Medical Center /ID# 267126
Hershey, Pennsylvania, United States
University of Pennsylvania - Perelman Center for Advanced Medicine /ID# 265904
Philadelphia, Pennsylvania, United States
Gastroenterology Associates of Orangeburg /ID# 267548
Orangeburg, South Carolina, United States
GI associates of Northeast Tennessee /ID# 265567
Johnson City, Tennessee, United States
Gi Alliance - Cedar Park /ID# 268153
Cedar Park, Texas, United States
Proactive Clinical Research /ID# 267305
El Paso, Texas, United States
Digestive Health Associates of Texas (DHAT) Research Institute - Garland /ID# 266935
Garland, Texas, United States
Houston Methodist Hospital /ID# 265533
Houston, Texas, United States
Caprock Gastro Research - Lubbock /ID# 265541
Lubbock, Texas, United States
GI Alliance - Mansfield /ID# 266947
Mansfield, Texas, United States
Clinical Associates in Research Therapeutics of America, LLC /ID# 265899
San Antonio, Texas, United States
Sun Research Institute /ID# 266723
San Antonio, Texas, United States
Southern Star Research Institute /ID# 278124
San Antonio, Texas, United States
Texas Digestive Disease Consultants - Southlake /ID# 265576
Southlake, Texas, United States
Tyler Research Institute /ID# 265545
Tyler, Texas, United States
Care Access - Ogden /ID# 266428
Ogden, Utah, United States
Care Access - Salt Lake City /ID# 266785
Salt Lake City, Utah, United States
Virginia Mason Hospital and Medical Center /ID# 265574
Seattle, Washington, United States
Washington Gastroenterology - Tacoma /ID# 267302
Tacoma, Washington, United States
Medizinische Universitaet Graz /ID# 275453
Graz, Styria, Austria
Medizinische Universitaet Innsbruck /ID# 265930
Innsbruck, Tyrol, Austria
Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 265929
Linz, Upper Austria, Austria
Klinikum Wels-Grieskirchen Gmbh /ID# 266035
Wels, Upper Austria, Austria
Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 265928
Salzburg, Austria
Medizinische Universitaet Wien /ID# 265926
Vienna, Austria
Imelda Ziekenhuis /ID# 265995
Bonheiden, Antwerpen, Belgium
Universite Libre de Bruxelles - Hopital Erasme /ID# 265993
Anderlecht, Brussels Capital, Belgium
CHU Saint-Pierre /ID# 266431
Brussels, Brussels Capital, Belgium
Cliniques Universitaires UCL Saint-Luc /ID# 265521
Brussels, Brussels Capital, Belgium
Groupe Sante CHC - Clinique du MontLegia /ID# 265522
Liège, Liege, Belgium
Universite Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 265517
Yvoir, Namur, Belgium
Universitair Ziekenhuis Leuven /ID# 265519
Leuven, Vlaams-Brabant, Belgium
AZ Groeninge /ID# 265544
Kortrijk, West-Vlaanderen, Belgium
AZ Oostende /ID# 275534
Ostend, West-Vlaanderen, Belgium
CHU de Liege /ID# 265542
Liège, Belgium
Hospital Tsaritsa Yoanna /ID# 266235
Sofiya, Sofia, Bulgaria
Medical Center - Doverie /ID# 267050
Sofiya, Sofia, Bulgaria
ACIBADEM City Clinic Diagnostic-Consultative Center /ID# 266239
Sofiya, Sofia, Bulgaria
Umbal Kaspela /ID# 266234
Plovdiv, Bulgaria
MHAT Knyaginya Klementina /ID# 266238
Sofia, Bulgaria
Acibadem City Clinic Tokuda University Hospital EAD /ID# 267437
Sofia, Bulgaria
Military Medical Academy Multiprofile Hospital /ID# 267051
Sofia, Bulgaria
UMHAT Multiprofile Hospital for Active Treatment Sveta Marina /ID# 266237
Varna, Bulgaria
University of Calgary /ID# 265524
Calgary, Alberta, Canada
Gastroenterology and Internal Medicine Research Institute /ID# 265610
Edmonton, Alberta, Canada
University of Alberta Hospital /ID# 265614
Edmonton, Alberta, Canada
Medicor Research /ID# 267405
Greater Sudbury, Ontario, Canada
London Health Sciences Centre - University Hospital /ID# 267298
London, Ontario, Canada
Toronto Digestive Disease Associates /ID# 267358
Vaughan, Ontario, Canada
Clinique IMD /ID# 272057
Montreal, Quebec, Canada
Diex Recherche Quebec Inc. /ID# 265611
Québec, Canada
Klinicki Bolnicki Centar Zagreb /ID# 265502
Grad Zagreb, City of Zagreb, Croatia
Poliklinika Solmed /ID# 265509
Zagreb, City of Zagreb, Croatia
Poliklinika Borzan d.o.o. /ID# 265503
Osijek, County of Osijek-Baranja, Croatia
Specialty Hospital Medico /ID# 265504
Rijeka, Primorje-Gorski Kotar County, Croatia