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A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients
Sponsor: AstraZeneca
Summary
This is a global, randomised, Phase III, multicentre, open-label study evaluating the efficacy, safety and the degree of added benefit of the Surovatamig (AZD0486) plus rituximab combination compared to Investigator's choice of 3 standard immunochemotherapy regimen, conducted in participants with untreated FL.
Official title: A Phase III, Multicentre, Randomised, Open-label Study to Compare the Efficacy and Safety of AZD0486 Plus Rituximab Versus Chemotherapy Plus Rituximab in Previously Untreated Participants With Follicular Lymphoma (SOUNDTRACK-F1)
Key Details
Gender
All
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
1018
Start Date
2024-08-07
Completion Date
2031-11-26
Last Updated
2026-10-21
Healthy Volunteers
No
Conditions
Interventions
Surovatamig
a fully human bispecific monoclonal IgG4 antibody
R-CHOP
Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone
R-CVP
Rituximab, Cyclophosphamide, Vincristine and Prednisone
BR
Bendamustine, Rituximab
Locations (244)
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Huntsville, Alabama, United States
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Anchorage, Alaska, United States
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Phoenix, Arizona, United States
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Clovis, California, United States
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Los Alamitos, California, United States
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San Diego, California, United States
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Santa Monica, California, United States
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Aurora, Colorado, United States
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New Haven, Connecticut, United States
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Newark, Delaware, United States
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Jacksonville, Florida, United States
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Atlanta, Georgia, United States
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Macon, Georgia, United States
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Evanston, Illinois, United States
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Peoria, Illinois, United States
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Fort Wayne, Indiana, United States
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Des Moines, Iowa, United States
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Iowa City, Iowa, United States
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Lexington, Kentucky, United States
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Louisville, Kentucky, United States
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Baton Rouge, Louisiana, United States
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Baltimore, Maryland, United States
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Bethesda, Maryland, United States
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Columbia, Maryland, United States
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Boston, Massachusetts, United States
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Boston, Massachusetts, United States
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Ann Arbor, Michigan, United States
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Detroit, Michigan, United States
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Ypsilanti, Michigan, United States
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Rochester, Minnesota, United States
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Saint Paul, Minnesota, United States
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Chesterfield, Missouri, United States
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Springfield, Missouri, United States
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Hackensack, New Jersey, United States
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New Brunswick, New Jersey, United States
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Albany, New York, United States
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Brooklyn, New York, United States
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Mineola, New York, United States
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New Hyde Park, New York, United States
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New York, New York, United States
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New York, New York, United States
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New York, New York, United States
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Charlotte, North Carolina, United States
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Charlotte, North Carolina, United States
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Wilmington, North Carolina, United States
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Winston-Salem, North Carolina, United States
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Blue Ash, Ohio, United States
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Cincinnati, Ohio, United States
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Columbus, Ohio, United States
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Eugene, Oregon, United States
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Portland, Oregon, United States
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Pittsburgh, Pennsylvania, United States
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Nashville, Tennessee, United States
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Austin, Texas, United States
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Lubbock, Texas, United States
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Shenandoah, Texas, United States
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Tyler, Texas, United States
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Salt Lake City, Utah, United States
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Fairfax, Virginia, United States
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Richmond, Virginia, United States
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Tacoma, Washington, United States
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Madison, Wisconsin, United States
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Milwaukee, Wisconsin, United States
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Clayton, Australia
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Darlinghurst, Australia
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Garran, Australia
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Heidelberg, Australia
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Macquarie University, Australia
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Nedlands, Australia
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Brussels, Belgium
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Brussels, Belgium
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Ghent, Belgium
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Mechelen, Belgium
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Porto Alegre, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Winnipeg, Manitoba, Canada
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Halifax, Nova Scotia, Canada
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Barrie, Ontario, Canada
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Hamilton, Ontario, Canada
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Oshawa, Ontario, Canada
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Toronto, Ontario, Canada
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Chicoutimi, Quebec, Canada
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Montreal, Quebec, Canada
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Québec, Quebec, Canada
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Saint-Jérôme, Quebec, Canada
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Beijing, China
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Beijing, China
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Beijing, China
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Changchun, China
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Changsha, China
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Chengdu, China
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Chongqing, China
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Fuzhou, China
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Guangzhou, China
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Guangzhou, China
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Guangzhou, China
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Hangzhou, China
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Hangzhou, China
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Harbin, China