Clinical Research Directory

Inclusion Criteria: * Understands the requirements of the study and provides written informed consent prior to undergoing any study-related procedures. * Subject is a male or female between the ages of 18-80 years old, inclusive. * Fitzpatrick skin type II or III. * History of at least one year of herpes labialis induced by UV exposure. * Able to recall exact location of most common or most recent outbreak. * History of at least 50% of cold sore outbreaks occurring with UV (sun) exposure. * At least 1 HSV-1 outbreak within the past 12 months. * Experiences prodromal symptoms before HSV-1 outbreaks. * Subject is willing and able to comply with protocol-specified dosing, visits to the clinic and tracking of pain. Exclusion Criteria: * Outbreak \<2 weeks prior to enrollment. * History of herpes simplex vaccine. * On antiviral suppression within the past 30 days. * Requires more than acetaminophen for pain from recurrent HSV outbreaks. * On any systemic or topical steroid, immune suppressant or chemotherapeutic agent within the past 14 days. * Use of tanning beds, history of sunburn, or beach vacation \<2 weeks prior to enrollment. * History of photosensitivity, lupus erythematosus, or current use of a highly photosensitizing medication in the opinion of the investigator. * Current immunosuppressed state due to underlying disease (i.e. HIV infection) concomitant treatment (i.e. chemotherapy). * Current upper respiratory tract infection or any active illness that could trigger cold sores or affect overall health of the patient or the assessment of the study agent. * Pregnant or intending to become pregnant during the study. * Abnormal skin conditions in the area of the recurrent HSV1 outbreaks. * Enrolled in another clinical trial within the past 30 days. * On any analgesics or NSAIDs that cannot be stopped during the study. * Alcohol or drug abuse.