Clinical Research Directory
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A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
Sponsor: Bristol-Myers Squibb
Summary
The purpose of this study is to compare the efficacy of Nivolumab and Relatlimab in combination with chemotherapy to Pembrolizumab with Chemotherapy in participants with stage IV or recurrent Non-squamous Non-small Cell Lung Cancer with PD-L1 expression ≥ 1%
Official title: A Phase 3, Randomized, Open-label Study of Nivolumab + Relatlimab Fixed-dose Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy as First-line Treatment for Participants With Non-squamous (NSQ), Stage IV or Recurrent Non-small Cell Lung Cancer and With Tumor Cell PD-L1 Expression ≥ 1%
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1000
Start Date
2024-10-07
Completion Date
2032-08-04
Last Updated
2026-10-23
Healthy Volunteers
No
Conditions
Interventions
Nivolumab
Specified dose on specified days
Relatlimab
Specified dose on specified days
Pembrolizumab
Specified dose on specified days
Carboplatin
Specified dose on specified days
Pemetrexed
Specified dose on specified days
Cisplatin
Specified dose on specified days
Locations (329)
Local Institution - 0487
Mobile, Alabama, United States
Southern Arizona VA Health Care System
Tucson, Arizona, United States
Local Institution - 0112
Los Angeles, California, United States
University of California Davis (UC Davis) Comprehensive Cancer Center
Sacramento, California, United States
Local Institution - 0159
San Francisco, California, United States
UCLA Hematology/Oncology - Santa Monica
Santa Monica, California, United States
Local Institution - 0500
Grand Junction, Colorado, United States
Local Institution - 0472
Westminster, Colorado, United States
Local Institution - 0206
Miami, Florida, United States
Local Institution - 0162
Pembroke Pines, Florida, United States
Florida Cancer Specialists - North
St. Petersburg, Florida, United States
Florida Clinical Trials Group.
Tamarac, Florida, United States
Florida Cancer Specialists - East
West Palm Beach, Florida, United States
Local Institution - 0509
Coeur d'Alene, Idaho, United States
Local Institution - 0376
Chicago Ridge, Illinois, United States
Cancer Center of Kansas
Wichita, Kansas, United States
Saint Elizabeth Medical Center Edgewood
Edgewood, Kentucky, United States
Baptist Health Lexington
Lexington, Kentucky, United States
Local Institution - 0502
Paducah, Kentucky, United States
Local Institution - 0505
Annapolis, Maryland, United States
Profound Research LLC - MHP MedOnc Royal Oak - Oakland Medical Group Location
Royal Oak, Michigan, United States
Local Institution - 0226
Hattiesburg, Mississippi, United States
Local Institution - 0498
Kansas City, Missouri, United States
Local Institution - 0308
Bozeman, Montana, United States
Renown Regional Medical Center
Reno, Nevada, United States
Local Institution - 0507
Morristown, New Jersey, United States
Local Institution - 0346
Paterson, New Jersey, United States
Local Institution - 0523
Summit, New Jersey, United States
Local Institution - 0381
Albuquerque, New Mexico, United States
Local Institution - 0356
Hawthorne, New York, United States
Local Institution - 0392
New York, New York, United States
Local Institution - 0380
Northport, New York, United States
University of Rochester Medical Center
Rochester, New York, United States
Local Institution - 0511
Schenectady, New York, United States
SUNY Upstate Medical University
Syracuse, New York, United States
Local Institution - 0357
The Bronx, New York, United States
Local Institution - 0352
Asheville, North Carolina, United States
East Carolina University
Greenville, North Carolina, United States
Local Institution - 0369
Canton, Ohio, United States
Local Institution - 0486
Centerville, Ohio, United States
University of Cincinnati Medical Center
Cincinnati, Ohio, United States
Local Institution - 0199
Cleveland, Ohio, United States
Local Institution - 0519
Elyria, Ohio, United States
Local Institution - 0366
Massillon, Ohio, United States
Local Institution - 0512
Zanesville, Ohio, United States
Lancaster General Hospital - Ann B Barshinger Cancer Institute
Lancaster, Pennsylvania, United States
Local Institution - 0504
Philadelphia, Pennsylvania, United States
Local Institution - 0520
Philadelphia, Pennsylvania, United States
Texas Oncology - West Texas
Abilene, Texas, United States
Local Institution - 0305
Harlingen, Texas, United States
University of Texas MD Anderson Cancer Center
Houston, Texas, United States
Local Institution - 0517
Houston, Texas, United States
The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center
Tyler, Texas, United States
Local Institution - 0302
Salt Lake City, Utah, United States
Local Institution - 0515
Edmonds, Washington, United States
Local Institution - 0516
Issaquah, Washington, United States
Local Institution - 0499
Lacey, Washington, United States
Local Institution - 0508
Seattle, Washington, United States
Hospital Británico de Buenos Aires
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Instituto Alexander Fleming
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
ABB, Buenos Aires F.D., Argentina
Instituto Médico Río Cuarto
Río Cuarto, Córdoba Province, Argentina
Local Institution - 0493
Bariloche, Río Negro Province, Argentina
Sanatorio Parque
Rosario, Santa Fe Province, Argentina
Hospital Privado Universitario de Córdoba
Córdoba, Argentina
Instituto Oncológico de Córdoba
Córdoba, Argentina
Hospital Privado de Comunidad
Mar del Plata, Argentina
Gosford Hospital
Gosford, New South Wales, Australia
GenesisCare North Shore
St Leonards, New South Wales, Australia
The Prince Charles Hospital
Brisbane, Queensland, Australia
Gallipoli Medical Research Ltd
Brisbane, Queensland, Australia
Local Institution - 0057
Elizabeth Vale, South Australia, Australia
Box Hill Hospital
Box Hill, Victoria, Australia
Fiona Stanley Hospital
Murdoch, Western Australia, Australia
St. John of God Murdoch Hospital
Murdoch, Western Australia, Australia
Universitätsklinikum Krems
Krems, Lower Austria, Austria
Klinikum Wels-Grieskirchen GmbH
Wels, Upper Austria, Austria
Klinik Floridsdorf
Vienna, Austria
Antwerp University Hospital
Edegem, Antwerpen, Belgium
UZ Brussel
Brussels, Bruxelles-Capitale, Région de, Belgium
Jessa Ziekenhuis
Hasselt, Limburg, Belgium
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne
Yvoir, Namur, Belgium
AZ Delta vzw
Roeselare, West-Vlaanderen, Belgium
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
Liège, Belgium
Pronutrir
Fortaleza, Ceará, Brazil
Cetus Oncologia - Unidade Belo Horizonte
Belo Horizonte, Minas Gerais, Brazil
CTO - Centro de Tratamento Oncológico
Belém, Pará, Brazil
Liga Norte Riograndense Contra o Câncer
Natal, Rio Grande do Norte, Brazil
Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil
Hospital São Lucas da PUCRS
Porto Alegre, Rio Grande do Sul, Brazil
Clínica de Neoplasias Litoral
Itajaí, Santa Catarina, Brazil
Local Institution - 0501
Timbó, Santa Catarina, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos
Barretos, São Paulo, Brazil
NAIC - Instituto do Câncer
Bauru, São Paulo, Brazil
Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
São Caetano do Sul, São Paulo, Brazil
Instituto do Câncer Brasil-unidade Taubaté
Taubaté, São Paulo, Brazil
Instituto Nacional de Câncer - INCA
Rio de Janeiro, Brazil
Icesp - Instituto Do Câncer Do Estado de São Paulo
São Paulo, Brazil
Local Institution - 0496
São Paulo, Brazil
Local Institution - 0494
Montreal, Quebec, Canada