Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study to Assess the Efficacy and Safety of Afimkibart (Also Known as RO7790121) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis
Sponsor: Hoffmann-La Roche
Summary
This Phase III, multicenter, double-blind, placebo-controlled, treat-through study will evaluate the efficacy and safety of Afimkibart (RO7790121) compared with placebo in participants with moderately to severely active ulcerative colitis (UC).
Official title: A Phase III, Multicenter, Double-Blind, Placebo-Controlled, Treat-Through Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With RO7790121 in Patients With Moderately to Severely Active Ulcerative Colitis
Key Details
Gender
All
Age Range
16 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2024-09-17
Completion Date
2031-01-30
Last Updated
2026-09-14
Healthy Volunteers
No
Interventions
Afimkibart
Afimkibart will be administered as IV infusion. Afimkibart will be administered as SC injection.
Placebo
Placebo matching IV afimkibart. Placebo matching SC afimkibart.
Locations (184)
Digestive Health Specialists of the Southeast (Gastroenterology Associates of Dothan) - Dothan
Dothan, Alabama, United States
Om Research LLC
Lancaster, California, United States
University of California Irvine
Orange, California, United States
Peak Gastroenterology Associates
Colorado Springs, Colorado, United States
Access Research Institute
Brooksville, Florida, United States
Gastro Florida
Clearwater, Florida, United States
Clinical Research of Osceola, LLC
Kissimmee, Florida, United States
Auzmer Research
Lakeland, Florida, United States
Florida Research Institute - Lakewood
Lakewood Rch, Florida, United States
Homestead Associates in Research, Inc.
Miami, Florida, United States
Allied Biomedical Research Institute, Inc
Miami, Florida, United States
Miami Beach Clinical Research Center
Miami Beach, Florida, United States
Theia Clinical Research Centers, LLC
Tampa, Florida, United States
Florida Medical Clinic
Zephyrhills, Florida, United States
Gastroenterology Associates of Central Georgia
Macon, Georgia, United States
Grand Teton Research Group, PLLC
Idaho Falls, Idaho, United States
The University of Chicago
Chicago, Illinois, United States
Indiana University Health University Hospital
Indianapolis, Indiana, United States
Gastroenterology Health Partners, PLLC
New Albany, Indiana, United States
Tri-State Gastroenterology Associates
Crestview Hills, Kentucky, United States
Gastroenterology Health Partners, PLLC
Louisville, Kentucky, United States
Louisiana Research Center - GastroIntestinal Associates
Shreveport, Louisiana, United States
Brigham & Womens Hosp
Boston, Massachusetts, United States
Boston University
Boston, Massachusetts, United States
Allied Gastrointestinal Associates, PA
Flowood, Mississippi, United States
Intercity Gastroenterology
Fresh Meadows, New York, United States
Pioneer Clinical Research NY
New York, New York, United States
Digestive Health Partners, PA
Asheville, North Carolina, United States
Peters Medical Research (PMR), LLC
High Point, North Carolina, United States
Monroe Biomedical Research
Monroe, North Carolina, United States
Cleveland Clinic Foundation
Cleveland, Ohio, United States
Ohio Gastroenterology Group
Columbus, Ohio, United States
Gastro Intestinal Research Institute of Northern Ohio
Westlake, Ohio, United States
University Gastroenterology
Providence, Rhode Island, United States
Medical University of South Carolina (MUSC)
Charleston, South Carolina, United States
Gastro One
Cordova, Tennessee, United States
Gastrointestinal Associates of Northeast Tennessee
Johnson City, Tennessee, United States
The University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, United States
GI Alliance
Garland, Texas, United States
TDDC dba GI Alliance Research
Mansfield, Texas, United States
Carta - Clinical Associates In Research Therapeutics Of America;LLC
San Antonio, Texas, United States
Southern Star Research Institute, LLC.
San Antonio, Texas, United States
Tyler Research Institute, LLC
Tyler, Texas, United States
University of Texas Health Center at Tyler
Tyler, Texas, United States
Tidewater Gastroenterology Pllc T/A Gastro. Assoc. of Tidewater
Chesapeake, Virginia, United States
Gastroenterology Consultants of SWVA
Roanoke, Virginia, United States
CIPREC Centro de Investigacion y Prevencion Cardiovascular
Ciudad Autonoma Buenos Aires, Argentina
Expertia S.A- Mautalen Salud e Investigación
Ciudad Autonoma Buenos Aires, Argentina
The Canberra Hospital
Garran, Australian Capital Territory, Australia
Royal Prince Alfred Hospital
Sydney, New South Wales, Australia
Mater Misericordiae Limited
South Brisbane, Queensland, Australia
Lyell McEwin Hospital
Adelaide, South Australia, Australia
Fiona Stanley Hospital
Murdoch, Western Australia, Australia
Medizinische Universität Innsbruck
Innsbruck, Austria
Barmherzige Brüder Wien
Vienna, Austria
CHC MontLégia
Liège, Belgium
CHU de Liège (Sart Tilman)
Liège, Belgium
Hospital de Clinicas de Porto Alegre X
Porto Alegre, Rio Grande do Sul, Brazil
CPQuali Pesquisa Clinica Ltda
São Paulo, São Paulo, Brazil
BR Trials - Pesquisa Clínica
São Paulo, São Paulo, Brazil
MHAT St. Ivan Rilski
Gorna Oryahovitsa, Bulgaria
South Edmonton Gastroenterology
Edmonton, Alberta, Canada
Hospital Guillermo Grant Benavente
Concepción, Chile
Clinica Universidad de Los Andes
Santiago, Chile
Medwal
Santiago, Chile
Peking University Third Hospital
Beijing, China
Binzhou Medical university hospital
Binzhou, China
the First Hospital of Jilin University
Changchun, China
Sichuan Provincial People's Hospital
Chengdu, China
The First Affiliated Hospital Of Fujian Medical University
Fuzhou, China
The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, China
The sixth affiliated hospital of Sun Yat-Sen University
Guangzhou, China
Anhui Provincial Hospital
Hefei, China
The First Affiliated Hospital of Anhui Medical University
Hefei, China
Huizhou First Hospital
Huizhou, China
Jinhua municipal central hospital
Jinhua, China
The 1st Affiliated Hospital of Nanchang Unversity
Nanchang, China
Nanjing 1st Hospital
Nanjing, China
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, China
Peking University Shenzhen Hospital
Shenzhen, China
Hebei Medical University - The Second Hospital
Shijiazhuang, China
Wuhan Union Hospital Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
Ren Min Hospital Affiliated Wu Han University
Wuhan, China
Wuxi People's Hospital
Wuxi, China
The Second Affiliated Hospital of Xi'an Jiao Tong University
Xi'an, China
The Second Affiliated Hospital of Zhengzhou University
Zhengzhou, China
Zhuzhou Central Hospital
Zhuzhou, China
Borzan Polyclinic
Osijek, Croatia
SurGal Clinic s.r.o.
Brno, Czechia
Nemocnice Ceske Budejovice a.s.
České Budějovice, Czechia
Gastroenterologie s.r.o.
Hradec Králové, Czechia
Herlev Hospital
Herlev, Denmark
CHU Amiens - Hopital Sud
Amiens, France
CHU Dijon Bourgogne Hôpital François Mitterand
Dijon, France
CH Dptal Les Oudairies
La Roche-sur-Yon, France
CHRU de Lille - Hopital Claude Huriez
Lille, France
Hopital Nord
Marseille, France
Institut des MICI, Clinique Ambroise Paré
Neuilly-sur-Seine, France
CHU Nice - Hopital de l'Archet 2
Nice, France
CHU Bordeaux - Hôpital Haut-Lévêque
Pessac, France