Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
RECRUITING
NCT06644781
PHASE3

A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)

Sponsor: Daiichi Sankyo

View on ClinicalTrials.gov

Summary

This study is designed to assess the efficacy and safety of ifinatamab deruxtecan (I-DXd) in patients with unresectable advanced or metastatic esophageal squamous cell carcinoma (ESCC) who have experienced disease progression following treatment with a platinum-based systemic therapy and an immune checkpoint inhibitor (ICI) compared with investigator's choice of chemotherapy (ICC).

Official title: A Phase 3, Multicenter, Randomized, Open-label Study of Ifinatamab Deruxtecan (I-DXd) in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

510

Start Date

2025-03-27

Completion Date

2029-11-01

Last Updated

2026-10-26

Healthy Volunteers

No

Interventions

DRUG

Ifinatamab deruxtecan

Intravenous administration

DRUG

Docetaxel

Intravenous administration

DRUG

Paclitaxel

Intravenous administration

DRUG

Irinotecan hydrochloride (HCl)

Intravenous administration

Locations (168)

Mayo Clinic Hospital

Phoenix, Arizona, United States

Providence Medical Foundation

Fullerton, California, United States

USC Norris Comprehensive Cancer Center

Los Angeles, California, United States

Univ of California Irvine College of Medicine

Orange, California, United States

Henry Ford Health System

Detroit, Michigan, United States

Mayo Clinic Rochester

Rochester, Minnesota, United States

MidAmerica Cancer Care - American Oncology Partners

Kansas City, Missouri, United States

Morristown Medical Center

Morristown, New Jersey, United States

Maimonides Cancer Center

Brooklyn, New York, United States

Penn State University Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

Baptist Cancer Center

Memphis, Tennessee, United States

SCRI Oncology Partners

Nashville, Tennessee, United States

John Peter Smith Hospital

Fort Worth, Texas, United States

Virginia Cancer Specialists

Fairfax, Virginia, United States

Institut Jules Bordet

Brussels, Belgium

Cliniques Universitaires Saint-Luc

Brussels, Belgium

Antwerp University Hospital

Edegem, Belgium

Universitair Ziekenhuis Gent

Ghent, Belgium

UZ Leuven

Leuven, Belgium

Chu de Liege

Liège, Belgium

Anyang Cancer Hospital

Anyang, China

Beijing Cancer Hospital

Beijing, China

Jilin Cancer Hospital

Changchun, China

The First Hospital of Jilin University

Changchun, China

Changzhou Cancer Hospital

Changzhou, China

Sichuan cancer hospital

Chengdu, China

West China Hospital Sichuan University

Chengdu, China

Fujian Cancer Hospital

Fuzhou, China

The First Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, China

Zhejiang Cancer Hospital

Hangzhou, China

Harbin Medical University Cancer Hospital

Harbin, China

Anhui Provincial Cancer Hospital

Hefei, China

The First Affiliated Hospital of Fujian Medical University

Hefei, China

The Second Hospital of Anhui Medical University

Hefei, China

Jieyang Peoples Hospital

Jieyang, China

Jinan Central Hospital

Jinan, China

Shandong Cancer Hospital

Jinan, China

Affiliated Hospital of Jining Medical University

Jining, China

Linyi Cancer Hospital

Linyi, China

The First Affiliated Hospital of Henan University of Science and Technology

Luoyang, China

Guangxi Medical University Affiliated Tumor Hospital

Nanning, China

Cancer Hospital of Shantou University Medical College

Shantou, China

Liaoning Cancer Hospital and Institute

Shenyang, China

Tianjin Medical University Cancer Institute and Hospital

Tianjin, China

The First Affiliated Hospital of Xinxiang Medical University

Weihui, China

Hubei Cancer Hospital

Wuhan, China

Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, China

Zhongshan Hospital Xiamen University

Xiamen, China

Subei Peoples Hospital

Yangzhou, China

Henan Cancer Hospital

Zhengzhou, China

Aarhus University Hospital

Arhus N, Denmark

Rigshospitalet

Copenhagen, Denmark

Odense University Hospital. Department of Research, Oncology

Odense C, Denmark

Sainte Catherine Institut du cancer Avignon en Provence

Avignon, France

CHU Brest - Hôpital de la Cavale Blanche

Brest, France

Centre Georges François Leclerc

Dijon, France

Hopital Claude Huriez - Chu Lille

Lille, France

Centre Leon Berard

Lyon, France

Institut Paoli Calmettes

Marseille, France

Institut Régional du Cancer de Montpellier

Montpellier, France

Chru De Nantes Hotel-Dieu

Nantes, France

Centre Antoine Lacassagne

Nice, France

Hôpital Européen Georges Pompidou

Paris, France

Hăpital Saint-Antoine

Paris, France

Chu Bordeaux - Hăpital Haut-Lăvăque

Pessac, France

CHU Poitiers - Hôpital la Milétrie

Poitiers, France

Crlcc Eugene Marquis

Rennes, France

Institut Curie - Centre Renă Huguenin

Saint-Cloud, France

Institut de Cancărologie de Strasbourg Europe - Icans

Strasbourg, France

CHU Toulouse Rangueil Service dOncologie médicale

Toulouse, France

Charité - Campus Charité Mitte

Berlin, Germany

Vivantes Klinikum Im Friedrichshain

Berlin, Germany

Universitaetsklinikum Bonn Aoer

Bonn, Germany

Universitaetsklinikum Carl Gustav Carus TU Dresden

Dresden, Germany

Krankenhaus Nordwest GmbH

Frankfurt am Main, Germany

Hämatologisch Onkologische Praxis Eppendorf HOPE

Hamburg, Germany

Asklepios Klinik Altona

Hamburg, Germany

Universitaetsklinikum Jena

Jena, Germany

Universitaetsklinikum Leipzig AoeR

Leipzig, Germany

Klinikum Nuernberg Nord

Nuremberg, Germany

Universitaetsklinikum Tuebingen

Tübingen, Germany

Clinica Oncologica-AOU delle Marche second floor

Ancona, Italy

National Institute of Gastroenterology Saverio De Bellis Research Hospital

Castellana Grotte, Italy

IRCCS Ospedale Policlinico San Martino

Genova, Italy

IRCCS Ospedale San Raffaele

Milan, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, Italy

Azienda Ospedaliera Universitaria Luigi Vanvitelli

Naples, Italy

IOV - Istituto Oncologico Veneto IRCCS

Padova, Italy

Azienda Ospedaliero Universitaria Pisana

Pisa, Italy

Fondazione Policlinico Gemelli

Rome, Italy

IRCCS Istituto Clinico Humanitas

Rozzano, Italy

A.O. Pia Fondazione Cardinale G. Panico

Tricase, Italy

National Cancer Center Hospital

Chūōku, Japan

Hiroshima University Hospital

Hiroshima, Japan

National Cancer Center Hospital East

Kashiwa, Japan

Kagawa University Hospital

Kita-gun, Japan

Kobe City Hospital Organization Kobe City Medical Center General Hospital

Kobe, Japan

Cancer Institute Hospital of JFCR

Kōtoku, Japan

Nho Shikoku Cancer Center

Matsuyama, Japan

Aichi Cancer Center

Nagoya, Japan

And 68 more locations on ClinicalTrials.gov