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Residual Inhibition of 40 Hz Burst Sound in Tinnitus Patients
Sponsor: Eye & ENT Hospital of Fudan University
Summary
Tinnitus affects 10-15% of adults and is frequently associated with impaired quality of life, anxiety, and sleep disturbance. Conventional sound therapies based on continuous masking provide inconsistent and short-lived relief, and the neural mechanisms underlying residual inhibition (RI) remain unclear. This study aims to determine whether 40 Hz burst stimulation with high-frequency carriers can achieve longer-lasting RI than continuous sound, and to explore its underlying neural mechanisms using EEG.
Official title: Reversible Suppression of a Phantom Percept is Associated With State-dependent Cortical Network Reconfiguration
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
363
Start Date
2024-10-28
Completion Date
2026-02-11
Last Updated
2026-10-27
Healthy Volunteers
No
Conditions
Interventions
Personalized 40 Hz Broadband Stimulation
Broadband acoustic stimulus (125 Hz-12 kHz) amplitude-modulated at 40 Hz with a 50% duty cycle. A polynomial regression and FFT-based algorithm applies individualized frequency weighting, combining population data (70%) and patient-specific responses (30%). Delivered for 60 seconds at 10 dB above the individual minimum masking level (MML).
40 Hz Pure Tone Stimulation
Pure tone stimulus at the optimized frequency (matched to tinnitus characteristics or high-frequency carrier), amplitude-modulated at 40 Hz with a 50% duty cycle. Delivered for 60 seconds at 10 dB above MML.
Continuous Broadband Noise
Continuous broadband noise spanning 125 Hz-12 kHz without 40 Hz modulation. Delivered for 60 seconds at 10 dB above MML as an active control condition.
Locations (1)
Eye & ENT Hospital of Fudan University
Shanghai, Shanghai Municipality, China