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RECRUITING

NCT06654336

PHASE2

Study of Recurrence-directed Therapy (RDT) With or Without Androgen-Deprivation Therapy (ADT) In Patients With Radio-recurrent Oligo-metastatic Hormone/Castrate Sensitive Prostate Cancer (romCSPC)

Sponsor: Ontario Clinical Oncology Group (OCOG)

View on ClinicalTrials.gov

Summary

The goal of this study is to determine whether the addition of Androgen Deprivation Therapy (ADT) utilizing the study drug ELIGARD® to Recurrence- Directed Therapy (RDT) improves progression-free survival (PFS) compared to RDT alone in patients with early radio-recurrent oligo-metastatic castrate / hormone sensitive prostate cancer (romCSPC). Participants will be assessed at standard of care clinic visits every 3 months. The follow-up period is 36 months.

Official title: Phase II Randomized Trial of Recurrence-directed Therapy (RDT) With or Without Androgen-Deprivation Therapy (ADT) In Radio-recurrent Oligo-metastatic Hormone/Castrate Sensitive Prostate Cancer (romCSPC).

Key Details

Gender

MALE

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

162

Start Date

2026-05-06

Completion Date

2031-06

Last Updated

2026-10-13

Healthy Volunteers

Conditions

Prostate Adenocarcinoma Castration Sensitive Prostate Cancer

Interventions

RADIATION

Recurrence-directed therapy (RDT)

RDT options include radiotherapy or surgical resection.

DRUG

ELIGARD 22.5mg

ADT in the form of ELIGARD 22.5 mg every 3 months for a total of 12 months.

Inclusion Criteria: 1. Previous biopsy-proven localized prostate adenocarcinoma (without predominant features of sarcomatoid, small cell or neuroendocrine carcinoma) treated with definitive or salvage radiotherapy ≥ 2 years or more before enrollment. 2. Recurrent Oligo-metastatic CSPC, M0 on conventional imaging (bone scan and CT scan of chest/abdomen/pelvis) with ≤ 5 metastases cumulative on all imaging, including MRI and PSMA-PET. Note: Patients with conventional imaging M1 oligometastatic CSPC, who have no more than 5 metastatic sites in all imaging modalities including MRI and PSMA-PET, will be accepted for study enrollment. 3. All sites of recurrent disease must be amenable to treatment with radiotherapy or surgery in the judgment of the investigator. 4. Biochemical recurrent prostate cancer with ONE of the following PSA recurrence definitions: 1. After definitive radiotherapy (prostate in situ), with PSA ≥ nadir + 2ng/ml; 2. After prostatectomy and adjuvant/salvage radiotherapy, with PSA ≥ nadir + 0.2ng/ml. Exclusion Criteria: 1. Age \< 18. 2. ECOG Performance Status ≥3. 3. PSA ≥ 20 ng/ml. 4. Treatment with ADT within 2 years from study enrollment or treatment with any androgen receptor axis within 6 months from study enrollment. 5. Prior treatment with chemotherapy for prostate cancer or bilateral orchiectomy. Note: prior chemotherapy for a different type of cancer is allowed if the patient has been continuously disease-free for \> 3 years. 6. Intracranial or intrathecal metastasis. 7. Spinal cord compression, or spinal intramedullary metastasis. 8. Prior malignancy (except non metastatic, non- melanomatous skin cancer) unless disease free for \> 3 years. 9. Bilateral hip prosthesis, treated earlier with definitive prostate radiotherapy, who have evidence of local disease recurrence within the prostate and no option for salvage treatment with brachytherapy or surgery. 10. Previous documented hypersensitivity to ELIGARD® or other GnRH agonist analogs of components of such preparations.

Locations (5)

Juravinski Cancer Centre

Hamilton, Ontario, Canada

The Ottawa Hospital Regional Cancer Centre

Ottawa, Ontario, Canada

University Health Network Princess Margaret Cancer Centre

Toronto, Ontario, Canada

Jewish General Hospital

Montreal, Quebec, Canada

McGill University Health Centre (MUHC) - Glen Site