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A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines
Sponsor: Takeda
Summary
Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects the joints and skin in people who have psoriasis (PsO). The main aim of the study is to know how well zasocitinib (TAK-279) works in participants with active PsA who have not previously been treated with biologic disease-modifying antirheumatic drugs. The participants will be treated with either zasocitinib, active comparator, or placebo. Participants will be in the study for up to 60 weeks.
Official title: A Multi-Center, Randomized, Double-Blind, Placebo- and Active-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of Zasocitinib (TAK-279) in Subjects With Active Psoriatic Arthritis Who Are Naïve to Biologic Disease-Modifying Antirheumatic Drugs (LATITUDE-PsA-3001)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1088
Start Date
2025-03-03
Completion Date
2028-01-28
Last Updated
2026-10-14
Healthy Volunteers
No
Conditions
Interventions
Zasocitinib
Zasocitinib over-encapsulated tablets.
Active Comparator
Active comparator capsule.
Placebo
Zasocitinib or active comparator matching placebo.
Locations (188)
AARR- Chandler AZ
Chandler, Arizona, United States
Arizona Arthritis & Rheumatology Research, PLLC | Phoenix, AZ
Phoenix, Arizona, United States
Arizona Arthritis & Rheumatology Research, PLLC | Phoenix, AZ
Phoenix, Arizona, United States
Arizona Arthritis & Rheumatology Research, PLLC | Phoenix, AZ
Phoenix, Arizona, United States
First OC Dermatology Research Inc.
Fountain Valley, California, United States
Purushotham & Akther Kotha MD
La Mesa, California, United States
Triwest Research Associates LLC
La Mesa, California, United States
The Cohen Medical Centers
Thousand Oaks, California, United States
Foothill Arthritis Clinic
Tujunga, California, United States
Medvin Clinical Research
Whittier, California, United States
Denver Arthritis Clinic | Denver, CO
Denver, Colorado, United States
Arthritis & Rheumatic Disease Specialties (AARDS)
Aventura, Florida, United States
RASF- Clinical Research Center
Boca Raton, Florida, United States
Clinical Research of West Florida | Clearwater, FL
Clearwater, Florida, United States
GNP Research, LLC | Hollywood, FL
Cooper City, Florida, United States
Driven Research LLC
Coral Gables, Florida, United States
Tectum Medical Research
Davie, Florida, United States
Sweet Hope Research Specialty, Inc, d/b/a Neoclinical Research
Hialeah, Florida, United States
Bioresearch Partners
Miami, Florida, United States
HMD Research LLC
Orlando, Florida, United States
Millennium Research | Ormond Beach, FL
Ormond Beach, Florida, United States
IRIS Research and Development | Plantation, FL
Plantation, Florida, United States
Sarasota Arthritis Research Center
Sarasota, Florida, United States
West Broward Rheumatology Associates, Inc.
Tamarac, Florida, United States
Clinical Research of West Florida | Tampa, FL
Tampa, Florida, United States
Marietta Rheumatology Associates
Marietta, Georgia, United States
GSCP/CIS
Orland Park, Illinois, United States
Greater Chicago Specialty Physicians LLC/CIS
Schaumburg, Illinois, United States
Accurate Clinical Research, Inc. | Lake Charles
Lake Charles, Louisiana, United States
Klein & Associates, M.D., P.A.
Hagerstown, Maryland, United States
Henry Ford Health System-Rheumatology Department
Detroit, Michigan, United States
Michigan Rheumatology Group, P.C. - Grand Blanc Office
Grand Blanc, Michigan, United States
Ash Research Clinic - Howell
Howell, Michigan, United States
June DO, PC Private Practice - Dr. Justus Fiechtner
Lansing, Michigan, United States
Clinical Research Institute of Michigan
Saint Clair Shores, Michigan, United States
Saint Louis Rheumatology
St Louis, Missouri, United States
Albuquerque Center for Rheumatology PC
Albuquerque, New Mexico, United States
Santa Fe Rheumatology
Santa Fe, New Mexico, United States
NYU Langone Health | Joseph S. and Diane H. Steinberg Ambulatory Care Center - Rheumatology Department
Brooklyn, New York, United States
Accellacare of Hickory
Hickory, North Carolina, United States
University Hospitals | UH Cleveland Medical Center - Department of Medicine - Rheumatology Division
Cleveland, Ohio, United States
Paramount Medical Research & Consulting, LLC
Middleburg Heights, Ohio, United States
PA Regional Center for Arthritis and Osteoporosis Research
Wyomissing, Pennsylvania, United States
West Tennessee Research Institute
Jackson, Tennessee, United States
Accurate Clinical Research
Baytown, Texas, United States
Novel Research | Bellaire Location
Bellaire, Texas, United States
Novel Research | Bellaire Location
Bellaire, Texas, United States
Accurate Clinical Research
Houston, Texas, United States
Introscience Research | Northwest Houston Arthritis Center - Houston, TX
Houston, Texas, United States
West Texas Clinical Research
Lubbock, Texas, United States
Southwest Rheumatology Research, LLC | Mesquite, TX
Mesquite, Texas, United States
Clinical Investigations of Texas
Plano, Texas, United States
Arthritis Northwest, PLLC | Spokane, WA
Spokane, Washington, United States
Université Libre de Bruxelles
Anderlecht, Brussels Capital, Belgium
University Hospital Ghent
Ghent, Flanders, Belgium
ReumaClinic Genk
Genk, Limburg, Belgium
St Pierre Brussels
Brussels, Belgium
Centre Hospitalier Universitaire (CHU) de Liege - Domaine Universitaire du Sart Tilman
Liège, Belgium
Diagnostic Consultative Centre - Focus-5 - LZIP EOOD
Sofia, Sofia-Grad, Bulgaria
Military Medical Academy Multiprofile Hospital for Not Yet Recruiting Treatment - Sofia
Sofia, Sofia-Grad, Bulgaria
Centre of Rheumatology St. Irina
Sofia, Sofia-Grad, Bulgaria
Medical Center Medconsult Pleven OOD
Pleven, Bulgaria
AES Partner Site -Plovdiv
Plovdiv, Bulgaria
Medical Center Artmed OOD | Plovdiv, Bulgaria
Plovdiv, Bulgaria
Diagnostic- Consultative Center- 1- Ruse EOOD
Rousse, Bulgaria
Dr Stoyanka Vladeva IPSMP VBR | Stara Zagora, Bulgaria
Stara Zagora, Bulgaria
Medical Center Zara-Med EOOD
Stara Zagora, Bulgaria
El Centro de Estudios Reumatologicos (CER)
Providencia, Santiago Metropolitan, Chile
Clinica Dermacross S.A.
Santiago, Santiago Metropolitan, Chile
Centro de Estudios Clinicos
Santiago, Chile
CTR Estudios
Santiago, Chile
Centro Internacional de Estudios Clínicos
Santiago, Chile
Medicinski Centar Kuna and Peric
Zagreb, City of Zagreb, Croatia
Clinical Hospital Centre Osijek
Osijek, Croatia
Clinical Hospital Center Rijeka
Rijeka, Croatia
University Hospital Centre Split
Split, Croatia
General Hospital Zadar
Zadar, Croatia
Revmatologie s.r.o. | Brno, Czech Republic
Brno, Czech Rep, Czechia
L.K.N. Arthrocentrum, s.r.o. - Revmatologicka
Hlučín, Czech Rep, Czechia
Clintrial s.r.o. | Prague, Czech Republic
Prague, Czech Rep, Czechia
Praglandia | Prague, Czech Republic
Prague, Czech Rep, Czechia
MEDICAL Plus s.r.o.
Uherské Hradiště, Czech Rep, Czechia
CCR Ostrava
Ostrava, Moravian-Silesian Region, Czechia
Pv Medical Services
Zlín, NAP, Czechia
Revmatologicky ustav | Clinical Evaluation Department
Prague, Prague, Czechia
Pratia Pardubice a.s.
Pardubice, Czechia
Innomedica OU | Tallinn, Estonia
Tallinn, Harju, Estonia
Center for Clinical and Basic Research
Tallinn, Harju, Estonia
Clinical Research Centre | Tartu, Estonia
Tartu, Tartu, Estonia
North Estonia Medical Centre | Mustamae Building - Internal Medicine Clinic - Rheumatology Department
Tallinn, Estonia
MediTrials OÜ
Tartu, Estonia
Fachklinik Bad Bentheim
Bad Bentheim, Lower Saxony, Germany
Rheumzentrum Prof.Dr.med.Gunther Neeck
Bad Doberan, Mecklenburg-Vorpommern, Germany
Rheumazentrum Ratingen-Studienambulanz
Ratingen, North Rhine-Westphalia, Germany
Universitaetsklinikum Leipzig AoeR
Leipzig, Saxony, Germany
Rheumatologische Schwerpunktpraxis | Berlin, Germany
Berlin, Germany
Städtisches Klinikum Dresden
Dresden, Germany
MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH - Hamburg
Hamburg, Germany
Medicover MVZ München Ost
München, Germany
Porcika Klinika
Hódmezővásárhely, Csongrad-Csanad, Hungary