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An Extension Study to Assess Impact of Multiple Sclerosis (MS) on Physical Function and Provide Continued Ocrelizumab Treatment
Sponsor: Hoffmann-La Roche
Summary
The study will evaluate the physical impact of MS from participant's perspective, provide continued access to ocrelizumab and assess the safety and tolerability of ocrelizumab. From Protocol Version 6 onwards, treatment within this study will be limited to the currently approved doses of ocrelizumab, 600 milligrams (mg), intravenous (IV) infusion or 920 mg, subcutaneous (SC) injection.
Official title: An Open-label, Multicenter Extension Study Evaluating the Patient Perspective of the Physical Impact of Multiple Sclerosis and Providing Continued Access to Ocrelizumab in Patients With Multiple Sclerosis Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Study and Without Access to a Post-trial Access Program
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
500
Start Date
2024-12-13
Completion Date
2029-12-31
Last Updated
2026-10-28
Healthy Volunteers
No
Conditions
Interventions
Ocrelizumab
Ocrelizumab will be administered at the approved dose of 600 mg, IV infusion or 920 mg, SC injection, according to the regimen in the parent study.
Locations (56)
MHAT Avis Medica OOD Department of Neurology
Pleven, Bulgaria
UMHAT 'Dr. Georgi Stranski', EAD
Pleven, Bulgaria
MHATNP Sveti Naum EAD
Sofia, Bulgaria
CHU Amiens Hopital Sud
Amiens Cedex1, France
CHIC Cote Basque Bayonne
Bayonne, France
CHU de Besancon Hopital Jean Minjoz
Besançon, France
Groupe Hospitalier Pellegrin
Bordeaux, France
CHU Brest Hopital La Cavale Blanche
Brest, France
Hopital neurologique Pierre Wertheimer - CHU Lyon
Bron, France
CHU De Caen
Caen, France
Hopital Gabriel Montpied CHU de Clermont-Ferrand
Clermont-Ferrand, France
CH St Vincent de Paul
Lille, France
Hopital Roger Salengro Service de Neurologie
Lille, France
Hopital Gui de Chauliac
Montpellier, France
Hopital Nord Laennec
Nantes, France
Hôpital Pasteur
Nice, France
GroupeHospitalo-Universitaire Caremeau
Nîmes, France
Centre Hospitalier Intercommunal de Poissy
Poissy, France
Hopital de Hautepierre
Strasbourg, France
Gesundheit Nord, Klinikum Bremen-Ost
Bremen, Germany
NeuroPoint Gesellschaft fur vorbeugende Gesundheitspflege mbH
Ulm, Germany
Studienzentrum Nordwest Dr med Joachim Springub Herr Wolfgang Schwarz
Westerstede, Germany
Deutsche Klinik für Diagnostik
Wiesbaden, Germany
Hospital IV Alberto Sabogal Sologuren
Bellavista, Peru
Hospital Nacional Guillermo Almenara Irigoyen
La Victoria, Lima, Peru
Hospital Nacional Dos de Mayo
Lima, Peru
Instituto Nacional de Ciencias Neurológicas - Hospital Mogrovejo
Lima, Peru
Krasnoyarsk State Medical Academy
Krasnoyarsk, Krasnoyarsk Krai, Russia
FSBHI Siberian Clinical Center of the Federal Medical and Biological Agency
Krasnoyarsk, Krasnoyarsk Krai, Russia
Research Center of Neurology of RAMS
Moscow, Moscow Oblast, Russia
City Clinical Hospital #24
Moscow, Moscow Oblast, Russia
Federal center of brain research and neurotechnologies
Moskva, Moscow Oblast, Russia
SBIH City Clinical Hospital #31
Saint Petersburg, Sankt-Peterburg, Russia
LLC Osnova
Saint Petersburg, Sankt-Peterburg, Russia
N.P. Bechtereva Institute of the Human Brain
Saint Petersburg, Sankt-Peterburg, Russia
City Hospital #40 of Kurortniy Administrative District
Saint Petersburg, Sankt-Peterburg, Russia
SHI Sverdlovsk Regional Clinical Hospital #1
Yekaterinburg, Sverdlovsk Oblast, Russia
Vertebronevrologiya LLC
Kazan', Tatarstan Republic, Russia
Ulyanovsk Regional Clinical Hospital
Ulyanovsk, Ulyanovsk Oblast, Russia
Center of Cardiology and Neurology
Kirov, Russia
Regional clinical hospital named after prof. S.V. Ochapovsky
Krasnodar, Russia
FSBIH Siberian Regional Medical Centre of FMBA of Russia
Novosibirsk, Russia
Perm SMA n.a. academ. E.A. Vagner
Perm, Russia
5th Cherkasy City Center of Primary Health Care
Cherkasy, Ukraine
Mun.Med.Proph.Inst.?Chernihiv Reg.Hosp.?
Chernihiv, Ukraine
Bukovinsky SMU RMI Chernivtsi RCH
Chernivtsi, Ukraine
SI USSRI of Medical and Social Problems of Disabilities of MOHU
Dnipro, Ukraine
Regional Clinical Hospital
Ivano-Frankivsk, Ukraine
St.In.Inst. of Neurol.Psych.and Narcol.of the AMSU
Kharkiv, Ukraine
Medical Center Dopomoga Plus
Kyiv, Ukraine
Medical Center of Private Execution First Private Clinic
Kyiv, Ukraine
Volyn Regional Clinical Hospital
Lutsk, Ukraine
Lvivska oblasna tsentralna likarnia
Lviv, Ukraine
Medical Clinical Research Center of Medical Center LLC Health Clinic
Vinnytsi, Ukraine
LCC "Medical center "Unimed"
Zaporizhzhya, Ukraine
Municipal Non-profit Enterprise Zaporizhzhya Regional Hospital Zaporizhzhya Regional Council
Zaporizhzhya, Ukraine