Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study of the Efficacy and Safety of Efgartigimod in Patients With Primary Sjögren's Syndrome
Sponsor: argenx
Summary
The main purpose of the proposed study is to evaluate the efficacy of efgartigimod PH20 SC in patients with moderate-to-severe Primary Sjögren's Disease (pSjD). The study consists of a double-blinded placebo-controlled treatment period and an open-label treatment period. The maximum study duration for participants in both study parts is approximately 105 weeks.
Official title: A Phase 3 Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial With Open-Label Extension to Evaluate the Efficacy, Safety, and Tolerability of Efgartigimod PH20 Subcutaneous Administered by Prefilled Syringe in Adult Patients With Primary Sjögren's Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
631
Start Date
2025-01-15
Completion Date
2028-07
Last Updated
2026-04-16
Healthy Volunteers
No
Conditions
Interventions
Efgartigimod PH20 SC
subcutaneous efgartigimod PH20 SC given by prefilled syringe
Placebo PH20 SC
subcutaneous placebo PH20 SC given by prefilled syringe
Locations (303)
One of a Kind Clinical Research Center LLC
Scottsdale, Arizona, United States
Arizona Arthritis & Rheumatology Research, PLLC
Sun City, Arizona, United States
Arizona Arthritis & Rheumatology Research, PLLC
Tucson, Arizona, United States
Providence Medical Foundation
Fullerton, California, United States
Stanford University School of Medicine
Stanford, California, United States
University of Colorado
Aurora, Colorado, United States
Clinical Research of West Florida, Inc.
Clearwater, Florida, United States
Centre for Rheumatology, Immunology and Arthritis
Fort Lauderdale, Florida, United States
Finlay Medical Research Corp
Greenacres City, Florida, United States
University of Florida College of Medicine Jacksonville
Jacksonville, Florida, United States
Life Clinical Trials
Margate, Florida, United States
Clinical Research of West Florida, Inc.
Tampa, Florida, United States
Conquest Research
Winter Park, Florida, United States
Piedmont Healthcare, Inc.
Atlanta, Georgia, United States
St. Luke's Clinic - Rheumatology
Boise, Idaho, United States
Chicago Clinical Research Institute
Chicago, Illinois, United States
Great Lakes Clinical Trials, LLC Ravenswood dba Flourish Research
Chicago, Illinois, United States
Chicago Arthritis & Regenerative Medicine
Chicago, Illinois, United States
Greater Chicago Specialty Physicians LLC
Orland Park, Illinois, United States
Arizona Arthritis & Rheumatology Research, PLLC
Willowbrook, Illinois, United States
Lake Cumberland Rheumatology
New Albany, Indiana, United States
University of Iowa Hospital and Clinics
Iowa City, Iowa, United States
Accurate Clinical Research Inc.
Lake Charles, Louisiana, United States
The Johns Hopkins Hospital
Baltimore, Maryland, United States
Arthritis and Rheumatism Associates
Rockville, Maryland, United States
Washington University School of Medicine
St Louis, Missouri, United States
Joseph S. and Diane H. Steinberg Ambulatory Care Center
Brooklyn, New York, United States
Samaritan Health Services
Corvallis, Oregon, United States
East Penn Rheumatology Associates, P.C.
Bethlehem, Pennsylvania, United States
Rheumatic Disease Associates, Ltd.
Willow Grove, Pennsylvania, United States
Allen Arthritis
Allen, Texas, United States
Accurate Clinical Management
Baytown, Texas, United States
Novel Research LLC
Bellaire, Texas, United States
Precision Comprehensive Clinical Research Solution
Colleyville, Texas, United States
Southwest Family Medicine Associates
Dallas, Texas, United States
Arizona Arthritis & Rheumatology Research, PLLC
Fort Worth, Texas, United States
Accurate Clinical Research, Inc.
Houston, Texas, United States
North Houston Arthritis Center
Houston, Texas, United States
Arizona Arthritis & Rheumatology Research, PLLC
Irving, Texas, United States
R and H Clinical Research
Katy, Texas, United States
Simcare Medical Research LLC
Sugar Land, Texas, United States
Velocity Clinical Research Waco
Waco, Texas, United States
Centro Medico Arsema
CABA, Buenos Aires, Argentina
Centro de Investigaciones Medicas Mar del Plata
Mar del Plata, Buenos Aires, Argentina
Instituto de Investigaciones Clinicas Quilmes
Quilmes, Buenos Aires, Argentina
Centro de Investigaciones San Miguel
San Miguel, Buenos Aires, Argentina
Sanatorio Parque S.A.
Rosario, Santa Fe Province, Argentina
Instituto CAICI
Rosario, Santa Fe Province, Argentina
Centro de Investigaciones Medicas Tucuman
San Miguel de Tucumán, Tucumán Province, Argentina
Centro de Investigaciones Reumatológicas
San Miguel de Tucumán, Tucumán Province, Argentina
STAT Research S.A.
Buenos Aires, Argentina
Centro Medico Barrio Parque
Buenos Aires, Argentina
Consultorios Reumatologicos Pampa
Buenos Aires, Argentina
Hospital Britanico de Buenos Aires
Buenos Aires, Argentina
APRILLUS Asistencia e Investigacion
Buenos Aires, Argentina
Westmead Hospital
Sydney, New South Wales, Australia
The Queen Elizabeth Hospital
Woodville South, South Australia, Australia
Monash Medical Centre Clayton
Clayton, Victoria, Australia
Fiona Stanley Hospital
Murdoch, Australia
Rheuma-Zentrum Wien Oberlaa
Vienna, Austria
Erasme Hospital
Brussels, Belgium
University Hospital Antwerp
Edegem, Belgium
ReumaClinic
Genk, Belgium
UZ Gent
Ghent, Belgium
UZ Leuven
Leuven, Belgium
MC Artmed OOD
Plovdiv, Bulgaria
UMHAT "Pulmed" OOD
Plovdiv, Bulgaria
MHAT Dr Ivan Seliminski AD
Sliven, Bulgaria
DCC "Alexandrovska" EOOD
Sofia, Bulgaria
Applied Medical Informatics Research Inc.
Montreal, Quebec, Canada
CHUS - Hôtel-Dieu
Sherbrooke, Quebec, Canada
G.R.M.O Groupe De Recherche En Maladie Osseuses Inc
Québec, Canada
CTR Estudios
Santiago, Chile
Enroll Spa
Santiago, Chile
BioMedica Research Group
Santiago, Chile
Centro de Estudios Reumatologicos
Santiago, Chile
Centro Medico Prosalud
Santiago, Chile
Clinical Research Chile SpA.
Valdivia, Chile
The First Affiliated Hospital of Bengbu Medical College
Bengbu, Anhui, China
Anhui Provincial Hospital
Hefei, Anhui, China
Sun Yat-sen Memorial Hospital
Guangzhou, Guangdong, China
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, China
The Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi Zhuang, China
The Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, China
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
The First Affiliated Hospital of Henan University of Science and Technology
Luoyang, Henan, China
Xinxiang Central Hospital
Xinxiang, Henan, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
Wuhan, Hubei, China
Huai'an First People's Hospital
Huai'an, Jiangsu, China
Nanjing Drum Tower Hospital
Nanjing, Jiangsu, China
Ganzhou People's Hospital
Ganzhou, Jiangxi, China
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
Pingxiang People's Hospital
Pingxiang, Jiangxi, China
The Second Hospital of Dalian Medical University
Dalian, Liaoning, China
Jining No.1 People's Hospital
Jining, Shandong, China
Affiliated Hospital of Jining Medical University
Jining, Shandong, China
Linyi People's Hospital
Linyi, Shandong, China
Linfen Central Hospital
Linfen, Shanxi, China