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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)
Sponsor: AstraZeneca
Summary
The purpose of ARTEMIDE-Lung02 is to assess the efficacy and safety of rilvegostomig in combination with platinum-based chemotherapy for the first-line (1L) treatment of patients with locally advanced or metastatic squamous non-small cell lung cancer (mNSCLC) whose tumors express programmed death-ligand 1 (PD-L1).
Official title: A Phase III, Randomized, Double-blind, Multicenter, Global Study of Rilvegostomig or Pembrolizumab in Combination With Platinum-based Chemotherapy for the First-line Treatment of Patients With Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer Whose Tumors Express PD-L1 (ARTEMIDE-Lung02)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1160
Start Date
2024-11-18
Completion Date
2030-07-01
Last Updated
2026-10-29
Healthy Volunteers
No
Conditions
Interventions
Rilvegostomig
Administered intravenously (IV) on Day 1 of each 21-day cycle
Pembrolizumab
Administered intravenously (IV) on Day 1 of each 21-day cycle
Carboplatin
Administered intravenously (IV) on Day 1 of each 21-day cycle up to 4 cycles
Paclitaxel
Administered intravenously (IV) on Day 1 of each 21-day cycle up to 4 cycles
Nab-paclitaxel
Administered intravenously (IV) on Days 1, 8, and 15 of each 21-day cycle up to 4 cycles
Locations (333)
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Tucson, Arizona, United States
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Springdale, Arkansas, United States
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Anaheim, California, United States
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Beverly Hills, California, United States
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Loma Linda, California, United States
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Los Alamitos, California, United States
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Redlands, California, United States
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San Francisco, California, United States
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Walnut Creek, California, United States
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West Haven, Connecticut, United States
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Newark, Delaware, United States
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Bay Pines, Florida, United States
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Fort Lauderdale, Florida, United States
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Gainesville, Florida, United States
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Gainesville, Florida, United States
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Jacksonville, Florida, United States
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Athens, Georgia, United States
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Atlanta, Georgia, United States
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Savannah, Georgia, United States
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Boise, Idaho, United States
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Chicago, Illinois, United States
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Decatur, Illinois, United States
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Hinsdale, Illinois, United States
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Quincy, Illinois, United States
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Rockford, Illinois, United States
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Fort Wayne, Indiana, United States
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Waterloo, Iowa, United States
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Lexington, Kentucky, United States
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Lexington, Kentucky, United States
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Louisville, Kentucky, United States
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Louisville, Kentucky, United States
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Alexandria, Louisiana, United States
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Baton Rouge, Louisiana, United States
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Covington, Louisiana, United States
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Shreveport, Louisiana, United States
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Shreveport, Louisiana, United States
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Scarborough, Maine, United States
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Baltimore, Maryland, United States
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Bethesda, Maryland, United States
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Bethesda, Maryland, United States
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Detroit, Michigan, United States
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Grand Rapids, Michigan, United States
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Saginaw, Michigan, United States
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Duluth, Minnesota, United States
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Rochester, Minnesota, United States
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Bridgeton, Missouri, United States
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Columbia, Missouri, United States
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Kansas City, Missouri, United States
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Lincoln, Nebraska, United States
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Camden, New Jersey, United States
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Buffalo, New York, United States
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East Syracuse, New York, United States
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Westbury, New York, United States
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Wilson, North Carolina, United States
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Grand Forks, North Dakota, United States
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Cincinnati, Ohio, United States
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Bend, Oregon, United States
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Medford, Oregon, United States
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Salem, Oregon, United States
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Hershey, Pennsylvania, United States
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York, Pennsylvania, United States
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Sioux Falls, South Dakota, United States
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Chattanooga, Tennessee, United States
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Nashville, Tennessee, United States
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Fort Worth, Texas, United States
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Houston, Texas, United States
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Kingwood, Texas, United States
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Lubbock, Texas, United States
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Round Rock, Texas, United States
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Fairfax, Virginia, United States
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Fredericksburg, Virginia, United States
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Olympia, Washington, United States
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Seattle, Washington, United States
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Silverdale, Washington, United States
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Spokane, Washington, United States
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Tacoma, Washington, United States
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Wenatchee, Washington, United States
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Buenos Aires, Argentina
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CABA, Argentina
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La Plata, Argentina
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Pilar, Argentina
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Rosario, Argentina
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Darlinghurst, Australia
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Hyde Park, Australia
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Southport, Australia
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Wollongong, Australia
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Innsbruck, Austria
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Krems, Austria
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Rankweil, Austria
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Vienna, Austria
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Vienna, Austria
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Anderlecht, Belgium
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Brussels, Belgium
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Charleroi, Belgium
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Kortrijk, Belgium
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Ottignies, Belgium
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Sint-Niklaas, Belgium
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Barretos, Brazil
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Florianópolis, Brazil
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Ijuí, Brazil