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Sedation and Guided Education for Depression Study
Sponsor: Stanford University
Summary
The goal of this clinical trial is to understand how patient education surrounding a one-time, consciousness-altering medical intervention impacts the antidepressant response to the intervention in adults with major depressive disorder. In this study, the consciousness-altering medical intervention is a single infusion of propofol, an intravenous anesthetic. In Part 1 of this study, we aim to answer: Does the focus of patient education influence the antidepressant response to a single intravenous infusion of propofol? In Part 2 of this study, we aim to answer: Does blocking opioid signaling affect the antidepressant response of patient education? Qualifying participants will: * Undergo a single intravenous infusion of propofol which will induce a temporary state of sedation * Wear an EEG cap that records brain activity during sedation * For Part 1: Be randomized to receive either response-focused or diagnosis-focused education about their brain signals after they recover from sedation. * For Part 2: Be randomized to receive a single dose of IV naloxone or IV saline during an educational intervention. * Be asked to fill out surveys about their mood and other measures of well-being throughout the study.
Official title: Randomized Controlled Trial Comparing the Impact of Patient Education Strategies on the Antidepressant Response to Propofol Sedation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-09
Completion Date
2028-10
Last Updated
2026-10-27
Healthy Volunteers
No
Conditions
Interventions
Response-focused education
Once participants recover from sedation, they will receive education that is focused on their response to treatment.
Diagnosis-focused education
Once participants recover from sedation, they will be provided education that is focused on their diagnosis of major depressive disorder.
IV naloxone
A single dose of IV naloxone given during the educational intervention.
IV saline
A single dose of IV saline given during the educational intervention.