Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
Sponsor: Janssen Research & Development, LLC
Summary
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) and and the length of time until a participant dies (overall survival), when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus either cetuximab or bevacizumab and FOLFIRI given to participants with Kirsten rat sarcoma viral oncogene/ neuroblastoma RAS viral oncogene homolog (KRAS/ NRAS) and v-raf murine sarcoma viral oncogene homolog B (BRAF) wild-type recurrent, unresectable or metastatic colorectal cancer who have previously received chemotherapy.
Official title: A Randomized, Open-label Phase 3 Study of Amivantamab + FOLFIRI Versus Cetuximab/Bevacizumab + FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Recurrent, Unresectable or Metastatic Colorectal Cancer Who Have Received Prior Chemotherapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
700
Start Date
2024-12-12
Completion Date
2029-04-13
Last Updated
2026-11-03
Healthy Volunteers
No
Conditions
Interventions
Amivantamab
Amivantamab will be administered.
Cetuximab
Cetuximab will be administered.
Bevacizumab
Bevacizumab will be administered.
5-fluorouracil
5-fluorouracil will be administered as chemotherapy regimen.
Leucovorin calcium/Levoleucovorin
Leucovorin calcium/Levoleucovorin will be administered as chemotherapy regimen.
Irinotecan
Irinotecan will be administered as chemotherapy regimen.
Locations (251)
Ironwood Cancer and Research Center
Chandler, Arizona, United States
Banner MD Anderson Cancer Center
Gilbert, Arizona, United States
Arizona Oncology Associates PC NAHOA
Prescott, Arizona, United States
St. Bernard's Medical Center
Jonesboro, Arkansas, United States
Highlands Oncology Group
Springdale, Arkansas, United States
CBCC Global Research
Bakersfield, California, United States
Los Angeles Cancer Network
Glendale, California, United States
Cancer and Blood Specialty Clinic
Los Alamitos, California, United States
USC Norris Comprehensive Cancer Center
Los Angeles, California, United States
UCLA
Santa Monica, California, United States
Providence Medical Foundation
Santa Rosa, California, United States
Torrance Memorial Physicians Network
Torrance, California, United States
University of Colorado Denver Anschultz Medical Campus
Aurora, Colorado, United States
Rocky Mountain Cancer Centers
Denver, Colorado, United States
Eastern Connecticut Hematology & Oncology Assoc.
Norwich, Connecticut, United States
Florida Cancer Specialists South
Fort Myers, Florida, United States
Mount Sinai Medical Center Campus
Miami Beach, Florida, United States
AdventHealth Cancer Institute
Orlando, Florida, United States
Florida Cancer Specialists North Region
St. Petersburg, Florida, United States
Florida Cancer Specialists East
West Palm Beach, Florida, United States
University Cancer And Blood Center LLC
Athens, Georgia, United States
Grady Memorial Hospital
Atlanta, Georgia, United States
Piedmont Cancer Institute
Atlanta, Georgia, United States
Winship Cancer Institute Emory University
Atlanta, Georgia, United States
Illinois Cancer Specialists
Arlington Heights, Illinois, United States
Illinois CancerCare
Peoria, Illinois, United States
Franciscan Health
Indianapolis, Indiana, United States
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States
Mission Cancer Blood
Waukee, Iowa, United States
Cancer Center of Kansas
Wichita, Kansas, United States
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, United States
MedStar Franklin Square Medical Center
Baltimore, Maryland, United States
Frederick Health Hospital - James M Stockman Cancer Institute
Frederick, Maryland, United States
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States
Henry Ford Hospital
Detroit, Michigan, United States
Cancer And Hematology Centers of Western Michigan PC
Grand Rapids, Michigan, United States
Hattiesburg Clinic
Hattiesburg, Mississippi, United States
Washington University School Of Medicine
St Louis, Missouri, United States
Nebraska Cancer Specialists
Omaha, Nebraska, United States
Astera Cancer Care
East Brunswick, New Jersey, United States
Perlmutter Cancer Center at NYU Long Island
Mineola, New York, United States
NYU Langone Medical Center NYU Hematology Associates
New York, New York, United States
New York Cancer and Blood Specialists
Shirley, New York, United States
Montefiore Einstein Comprehensive Cancer Center
The Bronx, New York, United States
University of Buffalo Kaleida Health Cancer Care
Williamsville, New York, United States
Gabrail Cancer Center
Canton, Ohio, United States
University Hospital of Cleveland
Cleveland, Ohio, United States
Oregon Health And Science University
Portland, Oregon, United States
Alliance Cancer Specialists at Main Line
Penn Wynne, Pennsylvania, United States
Thomas Jefferson University
Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States
Tennessee Oncology Chattanooga
Chattanooga, Tennessee, United States
SCRI Oncology Partners
Nashville, Tennessee, United States
Tennessee Oncology
Nashville, Tennessee, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Texas Oncology West Texas
Abilene, Texas, United States
Parkland Health and Hospital System
Dallas, Texas, United States
Texas Oncology DFW
Dallas, Texas, United States
UT Southwestern Medical Center
Dallas, Texas, United States
MD Anderson Cancer Center
Houston, Texas, United States
Baylor Scott & White Medical Center
Round Rock, Texas, United States
Texas Oncology - San Antonio
San Antonio, Texas, United States
Scott And White Memorial Hospital
Temple, Texas, United States
UT Health East Texas HOPE Cancer Center
Tyler, Texas, United States
Virginia Cancer Specialists
Arlington, Virginia, United States
Richmond VA Medical Center
Richmond, Virginia, United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia, United States
Providence Regional Cancer System
Lacey, Washington, United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States
Medical College Of Wisconsin
Milwaukee, Wisconsin, United States
Concord Hospital
Concord, Australia
Warringal Private Hospital
Heidelberg, Australia
Queen Elizabeth Hospital
South Woodville, Australia
Western Health Sunshine Hospital
St Albans, Australia
Institut Jules Bordet
Anderlecht, Belgium
UZ Antwerpen
Edegem, Belgium
AZ Maria Middelares
Ghent, Belgium
Jolimont
Haine Saint Paul La Louviere, Belgium
Az Groeninge
Kortrijk, Belgium
Universitair Ziekenhuis Leuven
Leuven, Belgium
Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman
Liège, Belgium
Fundacao Pio XII
Barretos, Brazil
Fundacao Universidade de Caxias do Sul
Caxias do Sul, Brazil
Fundacao Doutor Amaral Carvalho
Jaú, Brazil
Hospital Nossa Senhora da Conceicao S A
Porto Alegre, Brazil
Hospital Santa Izabel Santa Casa de Misericordia da Bahia
Salvador, Brazil
Funfarme Sjrp
São José do Rio Preto, Brazil
Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo
São Paulo, Brazil
Fundacao Antonio Prudente A C Camargo Cancer Center
São Paulo, Brazil
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
São Paulo, Brazil
Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia
Vitória, Brazil
Peking University First Hospital
Beijing, China
Beijing Friendship Hospital Capital Medical University
Beijing, China
Beijing Cancer Hospital
Beijing, China
The First Bethune Hospital of Jilin University
Changchun, China
Hunan Cancer hospital
Changsha, China
West China Hospital of Sichuan University
Chengdu, China
Ganzhou Cancer Hospital
Ganzhou, China
Sun Yat Sen University Cancer Center
Guangzhou, China