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A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer
Sponsor: Celgene
Summary
The purpose of this study is to compare the efficacy and safety of BMS-986365 versus the investigator's choice of therapy in participants with Metastatic Castration-resistant Prostate Cancer.
Official title: A Phase 3, Two-part, Randomized, Open-label, Adaptive Study Comparing BMS-986365 Versus Investigator's Choice of Therapy Comprising Either Docetaxel or Second Androgen Receptor Pathway Inhibitor (ARPI), in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) - rechARge
Key Details
Gender
MALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
960
Start Date
2025-03-13
Completion Date
2029-01-19
Last Updated
2026-09-30
Healthy Volunteers
No
Interventions
BMS-986365
Specified dose on specified days
Enzalutamide
Specified dose on specified days
Abiraterone
Specified dose on specified days
Docetaxel
Specified dose on specified days
Predinsone/Prednisolone
Specified dose on specified days
Locations (227)
Local Institution - 0330
Birmingham, Alabama, United States
Local Institution - 0329
Gilbert, Arizona, United States
Local Institution - 0370
Anaheim, California, United States
Local Institution - 0015
La Jolla, California, United States
Local Institution - 0224
Los Alamitos, California, United States
Local Institution - 0016
San Francisco, California, United States
Local Institution - 0411
San Francisco, California, United States
Local Institution - 0238
Aurora, Colorado, United States
Local Institution - 0294
Denver, Colorado, United States
Local Institution - 0419
Lakewood, Colorado, United States
Local Institution - 0413
Washington D.C., District of Columbia, United States
Local Institution - 0426
Lakeland, Florida, United States
Local Institution - 0077
Athens, Georgia, United States
Local Institution - 0048
Chicago, Illinois, United States
Local Institution - 0331
Westwood, Kansas, United States
Local Institution - 0060
Wichita, Kansas, United States
Local Institution - 0054
Baltimore, Maryland, United States
Local Institution - 0019
Baltimore, Maryland, United States
Local Institution - 0344
Frederick, Maryland, United States
Local Institution - 0429
Sewell, New Jersey, United States
Local Institution - 0081
Albuquerque, New Mexico, United States
Local Institution - 0334
Albuquerque, New Mexico, United States
Local Institution - 0197
Buffalo, New York, United States
Local Institution - 0412
Mineola, New York, United States
Local Institution - 0069
New York, New York, United States
Local Institution - 0076
New York, New York, United States
Local Institution - 0085
New York, New York, United States
Local Institution - 0071
New York, New York, United States
Local Institution - 0225
Syracuse, New York, United States
Local Institution - 0056
Columbus, Ohio, United States
Local Institution - 0067
Portland, Oregon, United States
Local Institution - 0416
Portland, Oregon, United States
Local Institution - 0345
Philadelphia, Pennsylvania, United States
Local Institution - 0414
Philadelphia, Pennsylvania, United States
Local Institution - 0057
Philadelphia, Pennsylvania, United States
Local Institution - 0349
Willow Grove, Pennsylvania, United States
Local Institution - 0055
Charleston, South Carolina, United States
Local Institution - 0079
Myrtle Beach, South Carolina, United States
Local Institution - 0335
Nashville, Tennessee, United States
Local Institution - 0018
Austin, Texas, United States
Local Institution - 0114
Austin, Texas, United States
Local Institution - 0042
Houston, Texas, United States
Local Institution - 0220
Houston, Texas, United States
Local Institution - 0109
Murray, Utah, United States
Local Institution - 0050
Charlottesville, Virginia, United States
Local Institution - 0078
Seattle, Washington, United States
Local Institution - 0293
Vancouver, Washington, United States
Local Institution - 0112
Milwaukee, Wisconsin, United States
Local Institution - 0125
CABA, Buenos Aires, Argentina
Local Institution - 0124
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Local Institution - 0128
ABB, Buenos Aires F.D., Argentina
Local Institution - 0235
Córdoba, Córdoba Province, Argentina
Local Institution - 0130
Río Cuarto, Córdoba Province, Argentina
Local Institution - 0136
Viedma, R, Argentina
Local Institution - 0129
Buenos Aires, Argentina
Local Institution - 0430
Córdoba, Argentina
Local Institution - 0366
Campbelltown, New South Wales, Australia
Local Institution - 0359
Darlinghurst, New South Wales, Australia
Local Institution - 0356
Macquarie University, New South Wales, Australia
Local Institution - 0360
Port Macquarie, New South Wales, Australia
Local Institution - 0355
Wahroonga, New South Wales, Australia
Local Institution - 0347
Greenslopes, Queensland, Australia
Local Institution - 0351
Southport, Queensland, Australia
Local Institution - 0362
Adelaide, South Australia, Australia
Local Institution - 0358
Elizabeth Vale, South Australia, Australia
Local Institution - 0352
Kurralta Park, South Australia, Australia
Local Institution - 0354
Hobart, Tasmania, Australia
Local Institution - 0363
Heidelberg, Victoria, Australia
Local Institution - 0353
Malvern, Victoria, Australia
Local Institution - 0348
Melbourne, Victoria, Australia
Local Institution - 0361
Melbourne, Victoria, Australia
Local Institution - 0357
Murdoch, Western Australia, Australia
Local Institution - 0369
Krems, Lower Austria, Austria
Local Institution - 0373
Linz, Upper Austria, Austria
Local Institution - 0367
Salzburg, Austria
Local Institution - 0368
Vienna, Austria
Local Institution - 0025
Belo Horizonte, Minas Gerais, Brazil
Local Institution - 0035
Natal, Rio Grande do Norte, Brazil
Local Institution - 0026
Porto Alegre, Rio Grande do Sul, Brazil
Local Institution - 0395
São Paulo, São Paulo, Brazil
Local Institution - 0031
São Paulo, São Paulo, Brazil
Local Institution - 0304
Kelowna, British Columbia, Canada
Local Institution - 0152
Vancouver, British Columbia, Canada
Local Institution - 0151
Halifax, Nova Scotia, Canada
Local Institution - 0193
Toronto, Ontario, Canada
Local Institution - 0093
Chicoutimi, Quebec, Canada
Local Institution - 0149
Montreal, Quebec, Canada
Local Institution - 0305
Montreal, Quebec, Canada
Local Institution - 0150
Québec, Quebec, Canada
Local Institution - 0164
Rimouski, Quebec, Canada
Local Institution - 0236
Valdivia, Los Ríos Region, Chile
Local Institution - 0135
Santiago, Santiago Metropolitan, Chile
Local Institution - 0132
Santiago, Santiago Metropolitan, Chile
Local Institution - 0127
Viña del Mar, Valparaiso, Chile
Local Institution - 0232
Hefei, Anhui, China
Local Institution - 0192
Beijing, Beijing Municipality, China
Local Institution - 0249
Fuzhou, Fujian, China
Local Institution - 0213
Xiamen, Fujian, China
Local Institution - 0226
Guangzhou, Guangdong, China
Local Institution - 0180
Guangzhou, Guangdong, China