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Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
Sponsor: Summit Therapeutics
Summary
Clinical study of ivonescimab for first-line treatment of metastatic NSCLC patients with high PD-L1. Evaluating overall survival and progression free survival.
Official title: A Randomized, Double-blinded, Multiregional Phase 3 Study of Ivonescimab Versus Pembrolizumab for the First-line Treatment of Metastatic Non-small Cell Lung Cancer in Patients Whose Tumors Demonstrate High PD-L1 Expression
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
780
Start Date
2025-02-27
Completion Date
2029-06
Last Updated
2026-09-18
Healthy Volunteers
No
Conditions
Interventions
Ivonescimab Injection
Subject will receive ivonescimab as an IV injection
Pembrolizumab Injection
Subject will receive Pembrolizumab as an IV injection
Locations (285)
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Chandler, Arizona, United States
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Phoenix, Arizona, United States
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Hot Springs, Arkansas, United States
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Jonesboro, Arkansas, United States
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Alameda, California, United States
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Anaheim, California, United States
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Beverly Hills, California, United States
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Cerritos, California, United States
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Los Angeles, California, United States
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Los Angeles, California, United States
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Orange, California, United States
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Oxnard, California, United States
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San Diego, California, United States
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Sunnyvale, California, United States
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Torrance, California, United States
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Aurora, Colorado, United States
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Denver, Colorado, United States
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Grand Junction, Colorado, United States
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Lone Tree, Colorado, United States
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Loveland, Colorado, United States
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Fort Lauderdale, Florida, United States
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Fort Lauderdale, Florida, United States
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Jacksonville, Florida, United States
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Jacksonville Beach, Florida, United States
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North Venice, Florida, United States
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Ocala, Florida, United States
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Orlando, Florida, United States
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Pensacola, Florida, United States
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Plantation, Florida, United States
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St. Petersburg, Florida, United States
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Tallahassee, Florida, United States
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Tamarac, Florida, United States
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West Palm Beach, Florida, United States
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Atlanta, Georgia, United States
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Warner Robins, Georgia, United States
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Carterville, Illinois, United States
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Chicago, Illinois, United States
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Chicago, Illinois, United States
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Evanston, Illinois, United States
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Indianapolis, Indiana, United States
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Waukee, Iowa, United States
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Lexington, Kentucky, United States
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Covington, Louisiana, United States
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Baltimore, Maryland, United States
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Boston, Massachusetts, United States
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Brighton, Massachusetts, United States
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Foxborough, Massachusetts, United States
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Methuen, Massachusetts, United States
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Milford, Massachusetts, United States
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Weymouth, Massachusetts, United States
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Worcester, Massachusetts, United States
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Ann Arbor, Michigan, United States
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Detroit, Michigan, United States
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Detroit, Michigan, United States
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Duluth, Minnesota, United States
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Minneapolis, Minnesota, United States
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Saint Paul, Minnesota, United States
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Hattiesburg, Mississippi, United States
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Kansas City, Missouri, United States
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St Louis, Missouri, United States
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St Louis, Missouri, United States
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Lebanon, New Hampshire, United States
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Mullica Hill, New Jersey, United States
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New Brunswick, New Jersey, United States
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New York, New York, United States
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Syracuse, New York, United States
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The Bronx, New York, United States
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Chapel Hill, North Carolina, United States
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Durham, North Carolina, United States
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Pinehurst, North Carolina, United States
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Cincinnati, Ohio, United States
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Cleveland, Ohio, United States
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Columbus, Ohio, United States
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Columbus, Ohio, United States
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Oklahoma City, Oklahoma, United States
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Eugene, Oregon, United States
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Portland, Oregon, United States
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Philadelphia, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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Greenville, South Carolina, United States
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Nashville, Tennessee, United States
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Nashville, Tennessee, United States
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Abilene, Texas, United States
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Austin, Texas, United States
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Dallas, Texas, United States
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Fort Worth, Texas, United States
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Houston, Texas, United States
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Tyler, Texas, United States
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Webster, Texas, United States
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Salt Lake City, Utah, United States
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Blacksburg, Virginia, United States
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Charlottesville, Virginia, United States
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Fairfax, Virginia, United States
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Richmond, Virginia, United States
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Richmond, Virginia, United States
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Seattle, Washington, United States
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Vancouver, Washington, United States
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Mons, Hainaut, Belgium
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Charleroi, Belgium
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Ghent, Belgium