Clinical Research Directory

Inclusion Criteria: * Age: Participants must be 22 years or older. * Lesion Characteristics: Participants must have primary skin lesions (i.e., not metastases or recurrent lesions) that are identified as suspicious by the patient or chosen for biopsy by non-dermatologist clinicians. * Lesion Size: The skin lesion must be 4 mm in diameter or greater. * Multiple Lesions: If a participant has multiple skin lesions, all lesions to be biopsied will be identified as individual skin lesions for the study. A maximum of three skin lesions may be measured per participant. * Informed Consent: Participants must be willing and able to read, comprehend, and sign the study-specific informed consent form. Exclusion Criteria: * Non-measurable Skin Surface: Lesions on skin surfaces that cannot be measured (e.g., lesions on a stalk). * Inaccessible Skin Surface: Lesions on skin surfaces that are not accessible (e.g., inside ears, under nails). * Specific Body Parts: Lesions located on the nose, lips, ears, or eyelids. * Acral Skin: Lesions located on acral skin (e.g., soles of the feet, palms of the hands). * Skin Conditions: Lesions located on areas with scars, crusts, psoriasis, eczema, dermatitis, or similar skin conditions that could influence blood flow where the lesion is located. * Hair-covered Areas: Lesions on hair-covered areas (e.g., scalp, beards, mustaches) unless the lesion is not covered by hair. * Genitalia: Lesions located on the genitalia. * Previously Biopsied or Traumatized Areas: Lesions located in areas that have been previously biopsied, subjected to any kind of surgical intervention, or traumatized. * Mucosal Surfaces: Lesions located on mucosal surfaces. * Non-intact Skin: Skin in the measurement area that is not intact (e.g., bleeding or with clinically noticeable ulceration). * Foreign Matter: Lesions with foreign matter present (e.g., tattoos, splinters). * Acute Sunburn: Lesions located on areas with acute sunburn. * Collision Lesions: Lesions that are collision lesions (i.e., lesions that overlap or are adjacent to each other). * Light Sensitivities: Patients with porphyria or other light sensitivities, such as phototoxicity or photoallergic reactions from antibiotics. * Dermatologist-selected Lesions: Lesions that have been selected by a dermatologist.