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RECRUITING
NCT06807918
PHASE2/PHASE3

Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder

Sponsor: University of Pennsylvania

View on ClinicalTrials.gov

Summary

This is a randomized, double-blind, crossover trial to evaluate the immediate effects of a nutritional ketone supplement, Kenotic compared to placebo on brain function and alcohol consumption in individuals with alcohol use disorder. Participants will complete 2 MRI scans, and 2 alcohol bar labs and will randomly receive Kenetik at one lab and the placebo at the next lab. During the bar labs participants will consume a dose of alcohol (based on weight), to bring their breath alcohol concentration to about 0.050%.

Official title: Effects of Ketone Supplementation on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder

Key Details

Gender

All

Age Range

21 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2026-12-01

Completion Date

2030-01-01

Last Updated

2026-10-21

Healthy Volunteers

No

Interventions

DIETARY_SUPPLEMENT

Kenetik

Drink a single dose of ketone supplement 25g, three times, randomly given at 1 of 2 MRI scan visits, and 1 of 2 alcohol bar lab visits.

OTHER

magnetic resonance imaging scan

Each subject will undergo 2 research MRI scan evaluations of the brain (up to 90 min.). The MRI is FDA-approved 7.0T Magentom Prisma scanner (Siemens Medical Solutions USA, Inc., Malvern, PA) with an approved radiofrequency head coil.

OTHER

Alcohol bar lab

Each subject will undergo 2 alcohol bar labs. Subjects will drink about 2 ½ standard alcohol beverages, based on their weight to reach a breath alcohol level of 0.050%.

OTHER

Placebo beverage

Drink a single dose of placebo beverage, that will look and taste the same as the ketone supplement. Subjects will receive the beverage three times, randomly given at 1 of 2 MRI scan visits, and 1 of 2 alcohol bar lab visits, opposite of the Kenetik beverage.

Locations (1)

Center for Studies of Addiction

Philadelphia, Pennsylvania, United States