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Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder
Sponsor: University of Pennsylvania
Summary
This is a randomized, double-blind, crossover trial to evaluate the immediate effects of a nutritional ketone supplement, Kenotic compared to placebo on brain function and alcohol consumption in individuals with alcohol use disorder. Participants will complete 2 MRI scans, and 2 alcohol bar labs and will randomly receive Kenetik at one lab and the placebo at the next lab. During the bar labs participants will consume a dose of alcohol (based on weight), to bring their breath alcohol concentration to about 0.050%.
Official title: Effects of Ketone Supplementation on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder
Key Details
Gender
All
Age Range
21 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-12-01
Completion Date
2030-01-01
Last Updated
2026-10-21
Healthy Volunteers
No
Conditions
Interventions
Kenetik
Drink a single dose of ketone supplement 25g, three times, randomly given at 1 of 2 MRI scan visits, and 1 of 2 alcohol bar lab visits.
magnetic resonance imaging scan
Each subject will undergo 2 research MRI scan evaluations of the brain (up to 90 min.). The MRI is FDA-approved 7.0T Magentom Prisma scanner (Siemens Medical Solutions USA, Inc., Malvern, PA) with an approved radiofrequency head coil.
Alcohol bar lab
Each subject will undergo 2 alcohol bar labs. Subjects will drink about 2 ½ standard alcohol beverages, based on their weight to reach a breath alcohol level of 0.050%.
Placebo beverage
Drink a single dose of placebo beverage, that will look and taste the same as the ketone supplement. Subjects will receive the beverage three times, randomly given at 1 of 2 MRI scan visits, and 1 of 2 alcohol bar lab visits, opposite of the Kenetik beverage.
Locations (1)
Center for Studies of Addiction
Philadelphia, Pennsylvania, United States