Clinical Research Directory
Browse clinical research sites, groups, and studies.
Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)
Sponsor: Daiichi Sankyo
Summary
This clinical trial is designed to evaluate the efficacy and safety of T-DXd in combination with bevacizumab versus bevacizumab monotherapy as first-line maintenance therapy, in participants with human epidermal growth factor 2 (HER2)-expressing (immunohistochemistry \[IHC\] 3+/2+/1+) advanced high-grade epithelial ovarian cancer.
Official title: A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Therapy in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01/ENGOT-ov89/GEICO144-O/GOG-3112/APGOT-OV13)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
582
Start Date
2025-03-19
Completion Date
2032-01-31
Last Updated
2026-10-28
Healthy Volunteers
No
Conditions
Interventions
Trastuzumab Deruxtecan
T-DXd will be administered at a dose of 5.4 mg/kg intravenously (IV) every 3 weeks (Q3W).
Bevacizumab
Bevacizumab will be administered at a dose of 15 mg/kg IV Q3W.
Locations (232)
Disney Family Cancer Center
Burbank, California, United States
Scripps Clinic
La Jolla, California, United States
Palo Alto Medical Foundation
Palo Alto, California, United States
Broward Health Medical Center
Fort Lauderdale, Florida, United States
Jupiter Medical Center
Jupiter, Florida, United States
Mount Sinai Medical Center
Miami Beach, Florida, United States
AdventHealth Cancer Institute
Orlando, Florida, United States
Woman's Care FL
St. Petersburg, Florida, United States
Nancy N. & J.C Lewis Cancer & Research Pavillion- St. Josephs/ Candler Health System
Savannah, Georgia, United States
Endeavor Health Evanston Kellogg Cancer Care Center
Evanston, Illinois, United States
Indiana University
Indianapolis, Indiana, United States
Trials365 LLC
Shreveport, Louisiana, United States
Greater Baltimore Medical Center
Towson, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Trinity Health St. Joseph Mercy Ann Arbor
Ann Arbor, Michigan, United States
Corewell Health
Grand Rapids, Michigan, United States
Minnesota Oncology Hematology PA
Minneapolis, Minnesota, United States
St. Vincent Gynecologic Oncology
Billings, Montana, United States
Valley Health System
Paramus, New Jersey, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, United States
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Columbia University
New York, New York, United States
UNC Hospital
Chapel Hill, North Carolina, United States
Miami Valley Hospital South
Centerville, Ohio, United States
Legacy Medical Group Gynecologic Oncology
Portland, Oregon, United States
Providence Cancer Center Oncology
Portland, Oregon, United States
St. Lukes University Health Network
Bethlehem, Pennsylvania, United States
Ann B Barshinger Cancer Institute
Lancaster, Pennsylvania, United States
Avera Medical Group Gynecologic
Sioux Falls, South Dakota, United States
Sarah Cannon Research Institute (Oncology Associates of Oregon PC)
Nashville, Tennessee, United States
Utah Cancer Specialists Network
Salt Lake City, Utah, United States
University of Wisconsin
Madison, Wisconsin, United States
Genesiscare St Andrews Hospital
Adelaide, Australia
Icon Cancer Centre Wesley
Auchenflower, Australia
Icon Cancer Centre Hobart
Hobart, Australia
Sir Charles Gairdner Hospital
Perth, Australia
Epworth Healthcare
Richmond, Australia
Genesis Care North Shore (Oncology)
St Leonards, Australia
Westmead Hospital
Sydney, Australia
Townsville University Hospital Cancer Centre
Townsville, Australia
Medizinische Universitat Innsbruck
Innsbruck, Austria
AZ Sint-Lucas
Ghent, Belgium
UZ Leuven
Leuven, Belgium
Groupe Sante CHC/Clinique du MontLegia
Liège, Belgium
CHU UCL Namur
Namur, Belgium
Cliniques Universitaires Saint-LUC
Woluwe-Saint-Lambert, Belgium
Oncocentro Belo Horizonte
Belo Horizonte, Brazil
Centro De Pesquisas Clinica Reichow
Blumenau, Brazil
Fundação Doutor Amaral Carvalho
Jaú, Brazil
Liga Norte-Rio-Grandense Contra o Cancer
Natal, Brazil
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa Hospital Mae de Deus
Porto Alegre, Brazil
Irmandade Da Santa Casa De Misericordia De Porto Alegre
Porto Alegre, Brazil
Ceon Pesquisas
Santo André, Brazil
Fundacao Faculdade Regional De Medicina De Sao Jose Do Rio Preto
São José do Rio Preto, Brazil
BP A Beneficencia Portuguesa de Sao Paulo
São Paulo, Brazil
Complex Oncology Center- Plovdiv EOOD
Plovdiv, Bulgaria
MHAT Park Hospital EOOD
Plovdiv, Bulgaria
MHAT Serdika EOOD
Sofia, Bulgaria
UMHAT Sofiamed EOOD
Sofia, Bulgaria
UMHAT Tsaritsa Yoanna ISUL EAD
Sofia, Bulgaria
Ushato Prof Ivan Chernozemski Ead
Sofia, Bulgaria
Beijing Cancer Hospital
Beijing, China
The First Hospital of Jilin University
Changchun, China
Hunan Cancer Hospital
Changsha, China
Sichuan University West China Second University Hospital
Chengdu, China
Chongqing Cancer Hospital
Chongqing, China
The Second Hospital of Dalian Medical University
Dalian, China
Fujian Cancer Hospital
Fuzhou, China
Sun Yat-Sen University Cancer Center
Guangzhou, China
Hainan General Hospital
Haikou, China
Women's Hospital School of Medicine Zhejiang University
Hangzhou, China
Zhejiang Cancer Hospital
Hangzhou, China
Harbin Medical University - Tumor Hospital
Harbin, China
Shandong Cancer Hospital
Jinan, China
Yunnan Cancer Hospital
Kunming, China
Jiangxi Maternal and Child Health Hospital
Nanchang, China
Zhong Da Hospital, Southeast University
Nanjing, China
Guangxi Medical University Cancer Hopstial
Nanning, China
Fudan University Shanghai Cancer Center
Shanghai, China
Liaoning Cancer Hospital & Institute
Shenyang, China
Affiliated Hospital (Suzhou First People's Hospital)
Suzhou, China
Shanxi Cancer Hospital
Taiyuan, China
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
Hubei Cancer Hospital
Wuhan, China
Tongji Hospital Tongji Medical College of HUST
Wuhan, China
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
Yantai Yuhuangding Hospital
Yantai, China
Henan Cancer Hospital
Zhengzhou, China
Fakultni Nemocnice Ostrava
Ostrava-Poruba, Czechia
Fakultni Nemocnice Bulovka
Prague, Czechia
Fakultni Nemocnice Kralovske Vinohrady
Prague, Czechia
Fakultni Nemocnice V Motole
Prague, Czechia
Vseobecna Fakultni Nemocnice V Praze
Prague, Czechia
Aarhus University Hospital
Aarhus, Denmark
Rigshospitalet
Copenhagen, Denmark
Sjællands Universitet Hospital
Roskilde, Denmark
Institut Bergonie
Bordeaux, France
Centre Georges Francois Leclerc
Dijon, France
Hopital Claude Huriez- CHU Lille
Lille, France