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Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0
Sponsor: Indiana University
Summary
There is a growing focus on short- and long-term kidney health in neonates, including those with acute kidney injury (AKI). AKI occurs commonly in the Neonatal Intensive Care Unit (NICU) and is associated with adverse outcomes. In addition to poor outcomes during the hospitalization, infants discharged from the NICU may have an increased burden of kidney disease during childhood. Studies of long-term kidney function in children born prematurely show a fourfold increase in chronic kidney disease (CKD) by adolescence and into adulthood. Despite the landmark findings of the Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) study, the limitations of this study are notable. First, the AWAKEN study enrolled infants admitted in 2014, making the data now over 10 years old. Much has changed in neonatal practice (e.g. increased AKI awareness, treatment strategies). Secondly, the findings of the AWAKEN study were geographically limited. While the AWAKEN study was multi-national and multi-center, it represented only 24 centers (22 from North America, 1 from India and 1 from Australia). Finally, information collected from AWAKEN ended at hospital discharge. The investigators seek to leverage the strength of the Neonatal Kidney Collaborative along with other organizations and collaboratives interested in neonatal kidney health to address these gaps. Therefore, the investigators are conducting a second, modified iteration of this study entitled "AWAKEN 2.0". AWAKEN 2.0 will be a multi-center multi-national retrospective analysis utilizing similar methodology to the AWAKEN study.
Official title: Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0: Towards Expanding Our Understanding of Neonatal Acute Kidney Injury
Key Details
Gender
All
Age Range
0 Minutes - 2 Weeks
Study Type
OBSERVATIONAL
Enrollment
8000
Start Date
2025-03-01
Completion Date
2027-06
Last Updated
2026-10-28
Healthy Volunteers
No
Conditions
Locations (125)
University of Alabama at Birmingham
Birmingham, Alabama, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Stanford Children's
Palo Alto, California, United States
Rady Children's Hospital/UCSD
San Diego, California, United States
Children's Hospital Colorado
Aurora, Colorado, United States
Connecticut Children's Medical Center
Hartford, Connecticut, United States
Yale University
New Haven, Connecticut, United States
Children's National Hospital
Washington D.C., District of Columbia, United States
Miami Children's / Nichlaus Children's Hospital
Miami, Florida, United States
Baptist Health South Florida/South Miami Hospital
South Miami, Florida, United States
Emory Healthcare / Children's Healthcare of Atlanta
Atlanta, Georgia, United States
Children's Hospital of Georgia
Augusta, Georgia, United States
Lurie Children's Hospital of Chicago
Chicago, Illinois, United States
SIU
Springfield, Illinois, United States
Indiana University School of Medicine
Indianapolis, Indiana, United States
Riley Hospital for Children
Indianapolis, Indiana, United States
University of Iowa
Iowa City, Iowa, United States
University of Kentucky
Lexington, Kentucky, United States
University of Louisville
Louisville, Kentucky, United States
University of Maryland
Baltimore, Maryland, United States
Johns Hopkins University/Hospital
Baltimore, Maryland, United States
Boston Children's Hospital
Boston, Massachusetts, United States
University of Michigan
Ann Arbor, Michigan, United States
University of Minnesota
Minneapolis, Minnesota, United States
Children's Mercy Hospital
Kansas City, Missouri, United States
Washington University
St Louis, Missouri, United States
Children's Nebraska
Omaha, Nebraska, United States
Maimonides Medical Center
Brooklyn, New York, United States
Cohen Children's Hospital
Queens, New York, United States
University of Rochester / Golisano Children's Hospital
Rochester, New York, United States
Stony Brook Medicine
Stony Brook, New York, United States
Children's Hospital at Montefiore
The Bronx, New York, United States
Westchester Medical Center/Maria Fareri Children's Hospital
Westchester, New York, United States
UNC
Chapel Hill, North Carolina, United States
Wake Forest
Winston-Salem, North Carolina, United States
Akron Children's Hospital
Akron, Ohio, United States
Cincinnati Children's Hospital
Cincinnati, Ohio, United States
Nationwide Children's
Columbus, Ohio, United States
OHSU
Portland, Oregon, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States
Medical University of South Carolina
Charleston, South Carolina, United States
Monroe Carell Jr. Children's Hospital at Vanderbilt
Nashville, Tennessee, United States
UT Southwestern
Dallas, Texas, United States
Texas Children's Hospital
Houston, Texas, United States
Texas Tech
Lubbock, Texas, United States
Christus Children's Hospital
San Antonio, Texas, United States
Primary Children's Hospital
Salt Lake City, Utah, United States
Golisano Children's Hospital at University of Vermont Health
Burlington, Vermont, United States
University of Virginia
Charlottesville, Virginia, United States
Seattle Children's Hospital / University of Washington
Seattle, Washington, United States
University of Wisconsin
Madison, Wisconsin, United States
Medical College of Wisconsin / Children's Wisconsin
Milwaukee, Wisconsin, United States
Hospital Italiano de Buenos Aires
Buenos Aires, Argentina
The Royal Children's Hospital Melbourne
Melbourne, Victoria, Australia
Canberra Hospital
Canberra, Australia
Royal Women's Hospital
Melbourne, Australia
Royal North Shore Hospital
North Sydney, Australia
Perth Children's Hospital
Perth, Australia
Sydney Children's Hospital Westmead
Sydney, Australia
Complexo Hospital de Clinicas da Universidade Federal do Parana (HCUFPR)
Curitiba, Brazil
Joana de Gusmao Children's Hospital
Florianópolis, Brazil
Hospital de Clinicas de Porto Alegre
Porto Alegre, Brazil
Centro Neonatal do Instituto da Criança e do Adolescente do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP)
São Paulo, Brazil
University of Sao Paulo
São Paulo, Brazil
British Columbia Children's Hospital
Vancouver, British Columbia, Canada
Mount Sinai Hospital
Toronto, Ontario, Canada
The Hospital for Sick Children
Toronto, Ontario, Canada
Alberta Children's Hospital/University of Calgary
Calgary, Canada
Stollery Children's Hospital
Edmonton, Canada
McMaster Children's Hospital
Hamilton, Canada
McGill University
Montreal, Canada
Sunnybrook Health Sciences Center
Toronto, Canada
Hospital Guillermo Grant Benavente
Concepción, Chile
Hospital Clinico Universidad Catolica de Chile
Santiago, Chile
Hospital Occidente de Kennedy
Bogotá, Colombia
Fundacion Valle del Lili Cali
Cali, Colombia
Clínica Universitaria Bolivariana
Medellín, Colombia
Hospital General de Medellin
Medellín, Colombia
Institute for the Care of Mother and Child
Prague, Czechia
Copenhagen University Hospital
Copenhagen, Denmark
Hopital des Enfants
Toulouse, France
Vian M. Iashvili Children's Central Hospital
Tbilisi, Georgia
University of Cologne
Cologne, Germany
Heidelberg University Hospital
Heidelberg, Germany
University of Marburg
Marburg, Germany
Aghia Sofia Children's Hospital
Athens, Greece
University Hospital of Heraklion
Heraklion, Greece
Aristotle University
Thessaloniki, Greece
Hippokration General Hospital of Thessaloniki
Thessaloniki, Greece
Papageorgiou General Hospital Thessaloniki
Thessaloniki, Greece
Hong Kong Children's Hospital
Hong Kong, Hong Kong
University of Szeged Children's Hospital
Szeged, Hungary
St. John's Medical College Hospital
Bengaluru, India
Dr. Mehta's Hospitals
Chennai, India
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Lucknow, India
Christian Medical College
Vellore, India
Dr. Cipto Mangunkusumo National General Hospital
Jakarta, Indonesia
Rambam Health Care Campus
Haifa, Israel
University Hospital of Padua
Padova, Italy