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Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
Sponsor: Amgen
Summary
The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight.
Official title: A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
3853
Start Date
2025-03-12
Completion Date
2027-04-16
Last Updated
2026-09-17
Healthy Volunteers
No
Conditions
Interventions
Maridebart Cafraglutide
Maridebart cafraglutide will be administered SC.
Placebo
Placebo will be administered SC.
Locations (243)
Pinnacle Research Group LLC
Anniston, Alabama, United States
Alliance For Multispecialty Research - Daphne
Daphne, Alabama, United States
Alliance for Multispecialty Research Mobile
Mobile, Alabama, United States
Avacare Foothills Research Center
Phoenix, Arizona, United States
Ark Clinical Research- Tustin
Fountain Valley, California, United States
Long Beach Clinical Trials Services Inc
Long Beach, California, United States
Ark Clinical Research- Long Beach
Long Beach, California, United States
Catalina Research Institute
Montclair, California, United States
Artemis Institute for Clinical Research
Riverside, California, United States
Artemis Institute for Clinical Research
San Diego, California, United States
Apex Clinical Research
San Diego, California, United States
Southern California Clinical Research
Santa Ana, California, United States
Diablo Clinical Research
Walnut Creek, California, United States
Yale School of Medicine
New Haven, Connecticut, United States
Chase Medical Research LLC
Waterbury, Connecticut, United States
Indago Research and Health Center
Hialeah, Florida, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
Clinical Neuroscience Solutions - Jacksonville
Jacksonville, Florida, United States
South Florida Wellness and Clinical Research Institute
Margate, Florida, United States
Optimus U Corporation
Miami, Florida, United States
Research Institute of South Florida
Miami, Florida, United States
Renstar Medical Research
Ocala, Florida, United States
Clinical Neuroscience Solutions - Orlando
Orlando, Florida, United States
Combined Research Orlando Phase I IV
Orlando, Florida, United States
Florida Institute for Clinical Research
Orlando, Florida, United States
Encore Medical Research of Weston LLC
Weston, Florida, United States
Center for Advanced Research and Education
Gainesville, Georgia, United States
Rophe Adult and Pediatric Medicine/Sky Clinical Research Network Group
Union City, Georgia, United States
East-West Medical Research
Honolulu, Hawaii, United States
Solaris Clinical Research
Meridian, Idaho, United States
Flourish Research - Great Lakes Clinical Trials
Chicago, Illinois, United States
Endeavor Health Medical Group - Endocrinology and Diabetes- Skokie
Skokie, Illinois, United States
Evanston Premier Healthcare Research LLC
Skokie, Illinois, United States
Alliance for Multispecialty Research Newton
Newton, Kansas, United States
Louisville Metabolic and Atherosclerosis Research Center
Louisville, Kentucky, United States
Velocity Clinical Research - Baton Rouge
Baton Rouge, Louisiana, United States
Tandem Clinical Research - Marrero
Marrero, Louisiana, United States
Headlands Research - Detroit
Southfield, Michigan, United States
Prime Health and Wellness Sky Clinical Research Network Group
Fayette, Mississippi, United States
Alliance for Multispecialty Research - Kansas City
Kansas City, Missouri, United States
Palm Research Center Inc
Las Vegas, Nevada, United States
Vector Clinical Trials
Las Vegas, Nevada, United States
Rochester Clinical Research
Rochester, New York, United States
Velocity Clinical Research- Binghamton
Vestal, New York, United States
Accellacare of Hickory
Hickory, North Carolina, United States
Carolina Research Center Inc
Shelby, North Carolina, United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States
Clinical Trial Investigator Clinical Research Center
Cincinnati, Ohio, United States
Velocity Clinical Research - Cincinnati
Cincinnati, Ohio, United States
Alliance for Multispecialty Research - Norman
Norman, Oklahoma, United States
Capital Area Research LLC
Newport, Pennsylvania, United States
Velocity Clinical Research - Providence
East Greenwich, Rhode Island, United States
Tribe Clinical Research LLC Dba Mountain View Clinical Research
Greenville, South Carolina, United States
New Phase Research and Development
Knoxville, Tennessee, United States
Accellacare US Inc., d/b/a Accellacare of Knoxville
Knoxville, Tennessee, United States
Elligo Clinical Research Center
Austin, Texas, United States
Cedar Health Research, LLC
Dallas, Texas, United States
Epic Medical Research - Texas
DeSoto, Texas, United States
Great Lakes Research Institute El Paso Research
El Paso, Texas, United States
Cedar Health Research, LLC
Euless, Texas, United States
Juno Research LLC
Houston, Texas, United States
Biopharma Informatic, LLC
Houston, Texas, United States
Juno Research LLC
Houston, Texas, United States
Southern Endocrinology Associates PA
Mesquite, Texas, United States
Great Lakes Research Institute - McAllen Research
Pharr, Texas, United States
Clinical Trials of Texas
San Antonio, Texas, United States
Sugar Lakes Family Practice
Sugar Land, Texas, United States
Pantheon Clinical Research
Bountiful, Utah, United States
Alliance for Multispecialty Research Layton Research Center
Layton, Utah, United States
Chrysalis Clinical Research, LLC
St. George, Utah, United States
Washington Center for Weight Management and Research, Inc
Arlington, Virginia, United States
Health Research of Hampton Roads
Newport News, Virginia, United States
Selma Medical Associates
Winchester, Virginia, United States
Allegiance Research Specialists
Milwaukee, Wisconsin, United States
Cedic - Centro de Investigacion Clinica
CABA, Buenos Aires, Argentina
Centro Medico Viamonte
CABA, Buenos Aires, Argentina
Cemedic Centro de Especialidades Medicas
CABA, Buenos Aires, Argentina
Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada
CABA, Buenos Aires, Argentina
Consultorios Medicos Dr Besada
CABA, Buenos Aires, Argentina
Fundacion Respirar
CABA, Buenos Aires, Argentina
Cinme - Centro de Investigaciones Metabolicas
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Ciprec - Centro de Investigacion y Prevencion Cardiovascular
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Emeritus Research Sydney
Botany, New South Wales, Australia
Novatrials
Charlestown, New South Wales, Australia
Canopy Clinical Sutherland
Miranda, New South Wales, Australia
Royal North Shore Hospital
St Leonards, New South Wales, Australia
Canopy Clinical Wollongong
Wollongong, New South Wales, Australia
Logan Hospital
Meadowbrook, Queensland, Australia
Fusion Clinical Research
Norwood, South Australia, Australia
Southern Adelaide Diabetes and Endocrine Services
Oaklands Park, South Australia, Australia
Emeritus Research Camberwell
Camberwell, Victoria, Australia
Austin Health, Heidelberg Repatriation Hospital
Heidelberg West, Victoria, Australia
Canopy Clinical Altona North
North Altona, Victoria, Australia
Universitair Ziekenhuis Antwerpen
Edegem, Belgium
Universitair Ziekenhuis Gent
Ghent, Belgium
Algemeen Ziekenhuis Groeninge - Campus Kennedylaan
Kortrijk, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
Leuven, Belgium
Centre Hospitalier Universitaire de Liege - Sart Tilman
Liège, Belgium
Algemeen Ziekenhuis Sint-Maarten
Mechelen, Belgium
Centres Hospitaliers Universitaires HELORA - Hôpital de Mons - Site Constantinople
Mons, Belgium