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Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
Sponsor: Amgen
Summary
The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight.
Official title: A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight (MARITIME-2)
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
1105
Start Date
2025-03-17
Completion Date
2027-04-16
Last Updated
2025-12-31
Healthy Volunteers
No
Interventions
Maridebart cafraglutide
Maridebart cafraglutide will be adminstered SC.
Placebo
Placebo will be adminstered SC.
Locations (187)
Alliance for Multispecialty Research Mobile
Mobile, Alabama, United States
Gilbert Center for Family Medicine
Gilbert, Arizona, United States
Desert Clinical Research
Mesa, Arizona, United States
Avacare Foothills Research Center
Phoenix, Arizona, United States
San Fernando Valley Health Institute
Canoga Park, California, United States
Core Healthcare Group
Cerritos, California, United States
Velocity Clinical Research Chula Vista
Chula Vista, California, United States
Headlands Research California
Escondido, California, United States
Paradigm Clinical Research
Modesto, California, United States
Flourish Research
Northridge, California, United States
University of California Irvine
Orange, California, United States
Empire Clinical Research
Pomona, California, United States
Infinity Clinical Trials
San Diego, California, United States
Greenwich Clinical Trials
Riverside, Connecticut, United States
Indago Research and Health Center
Hialeah, Florida, United States
Optimus U Corporation
Miami, Florida, United States
New Horizon Research Center
Miami, Florida, United States
San Marcus Research Clinic Inc
Miami Lakes, Florida, United States
Florida Institute for Clinical Research
Orlando, Florida, United States
Encore Medical Research of Weston LLC
Weston, Florida, United States
Conquest Research - Winter Park
Winter Park, Florida, United States
Alliance For Multispecialty Research - Oak Brook
Oak Brook, Illinois, United States
Alliance for Multispecialty Research, LLC - Park Ridge
Park Ridge, Illinois, United States
Endeavor Health Medical Group - Endocrinology and Diabetes- Skokie
Skokie, Illinois, United States
Indiana Medical Research Institute
Merrillville, Indiana, United States
Iowa Diabetes Research
West Des Moines, Iowa, United States
Alliance for Multispecialty Research Newton
Newton, Kansas, United States
Alliance for Multispecialty Research LLC
Wichita, Kansas, United States
Advanced Internal Medicine
Paducah, Kentucky, United States
Ima Clinical Research- Monroe
Monroe, Louisiana, United States
Annapolis Internal Medicine, LLC
Annapolis, Maryland, United States
Brigham and Womens Hospital
Boston, Massachusetts, United States
International Diabetes Center - HealthPartners Institute
Minneapolis, Minnesota, United States
Alliance for Multispecialty Research - Kansas City
Kansas City, Missouri, United States
Palm Research Center Inc
Las Vegas, Nevada, United States
Vector Clinical Trials
Sparks, Nevada, United States
Premier Research
Trenton, New Jersey, United States
Albany Medical College
Albany, New York, United States
Asheville Clinical Research
Asheville, North Carolina, United States
Physicians East
Greenville, North Carolina, United States
Carteret Medical Group
Morehead City, North Carolina, United States
West Clinical Research
Morehead City, North Carolina, United States
Velocity Clinical Research - Cincinnati
Blue Ash, Ohio, United States
Velocity Clinical Research - Springdale
Cincinnati, Ohio, United States
Velocity Clinical Research - Providence
East Greenwich, Rhode Island, United States
Medical Care LLC
Elizabethton, Tennessee, United States
Elligo Clinical Research Center
Austin, Texas, United States
Osvaldo A Brusco MD PA
Corpus Christi, Texas, United States
Cedar Health Research, LLC
Dallas, Texas, United States
Soma Clinical Trials, LLC
Denison, Texas, United States
Cedar Health Research, LLC
Euless, Texas, United States
Juno Research LLC
Houston, Texas, United States
Juno Research LLC
Houston, Texas, United States
Tekton Research
McKinney, Texas, United States
Northeast Clinical Research of San Antonio LLC
San Antonio, Texas, United States
Alliance for Multispecialty Research - Layton
Layton, Utah, United States
Manassas Clinical Research Center Inc
Manassas, Virginia, United States
VA Puget Sound Healthcare System
Seattle, Washington, United States
Ima Clinical Research - West Virginia
Morgantown, West Virginia, United States
Centro Medico Viamonte
CABA, Buenos Aires, Argentina
Cedic Centro de Investigacion Clinica
CABA, Buenos Aires, Argentina
Cemedic Centro de Especialidades Medicas
CABA, Buenos Aires, Argentina
Maffei Centro Medico
CABA, Buenos Aires, Argentina
Consultorios Medicos Dr Besada
CABA, Buenos Aires, Argentina
Cinme - Centro de Investigaciones Metabolicas
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Ciprec Centro de Investigacion y Prevencion Cardiovascular
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Ambulatory for specialized outpatient medical aid in endocrinology-Dr Albena Dinkova EOOD
Pleven, Bulgaria
Diagnostic - Consultative Center XX - Sofia EOOD
Sofia, Bulgaria
Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD
Sofia, Bulgaria
University Multiprofile Hospital for Active Treatment Sofiamed OOD
Sofia, Bulgaria
Prevencia-2000-Medical center for outpatient medical aid OOD
Stara Zagora, Bulgaria
Medical Center Berbatov EOOD
Yambol, Bulgaria
tlc Diabetes and Endocrinology
Surrey, British Columbia, Canada
Chronic Disease Innovation Centre
Winnipeg, Manitoba, Canada
Nova Scotia Health Authority, Queen Elizabeth ii Health Sciences Centre
Halifax, Nova Scotia, Canada
Centricity Research Brampton
Brampton, Ontario, Canada
Aggarwal and Associates Ltd
Brampton, Ontario, Canada
Centricity Research Vaughan
Concord, Ontario, Canada
Winterberry Family Medicine
Hamilton, Ontario, Canada
Premier Clinical Trial Network
Hamilton, Ontario, Canada
Milestone Research
London, Ontario, Canada
Centricity Research Ottawa LMC
Nepean, Ontario, Canada
Your Research Network Inc.
Niagara Falls, Ontario, Canada
North York Diagnostic and Cardiac Centre
North York, Ontario, Canada
Bluewater Clinical Research Group Incorporated
Sarnia, Ontario, Canada
Albion Finch Medical Centre
Toronto, Ontario, Canada
Centricity Research Quebec City
Lévis, Quebec, Canada
Institut de recherches cliniques de Montreal
Montreal, Quebec, Canada
Centre Medical Acadie
Montreal, Quebec, Canada
Centricity Research Pointe-Claire
Pointe-Claire, Quebec, Canada
Diex Recherche Trois Rivieres
Trois-Rivières, Quebec, Canada
Fakultni nemocnice Brno
Brno, Czechia
CCR Ostrava sro
Ostrava, Czechia
Diahelp sro
Pardubice, Czechia
Pratia Pardubice as
Pardubice, Czechia
Fakultni nemocnice Kralovske Vinohrady
Prague, Czechia
Vseobecna fakultni nemocnice v Praze
Prague, Czechia
Institut klinicke a experimentalni mediciny
Prague, Czechia
Milan Kvapil sro
Prague, Czechia
Restrial sro
Prague, Czechia