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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
Sponsor: AstraZeneca
Summary
A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Tezepelumab in Adults with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD)
Official title: A Randomised, Double-blind, Placebo-controlled, Parallel Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Key Details
Gender
All
Age Range
40 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
990
Start Date
2025-03-18
Completion Date
2029-06-05
Last Updated
2026-09-03
Healthy Volunteers
No
Interventions
Tezepelumab
Tezepelumab subcutaneous injection
Placebo
Placebo subcutaneous injection
Locations (305)
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Foley, Alabama, United States
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Mobile, Alabama, United States
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Sheffield, Alabama, United States
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Phoenix, Arizona, United States
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Phoenix, Arizona, United States
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Tucson, Arizona, United States
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Garden Grove, California, United States
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Newport Beach, California, United States
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Torrance, California, United States
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Clearwater, Florida, United States
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Cutler Bay, Florida, United States
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Cutler Bay, Florida, United States
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DeBary, Florida, United States
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Gainesville, Florida, United States
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Homestead, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Orlando, Florida, United States
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Tampa, Florida, United States
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Tampa, Florida, United States
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Atlanta, Georgia, United States
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Lithonia, Georgia, United States
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Rincon, Georgia, United States
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Meridian, Idaho, United States
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Chicago, Illinois, United States
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Palos Hills, Illinois, United States
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Winfield, Illinois, United States
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Munster, Indiana, United States
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Baltimore, Maryland, United States
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Columbia, Maryland, United States
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North Dartmouth, Massachusetts, United States
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Farmington Hills, Michigan, United States
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Saint Cloud, Minnesota, United States
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St Louis, Missouri, United States
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St Louis, Missouri, United States
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Missoula, Montana, United States
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Papillion, Nebraska, United States
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Las Vegas, Nevada, United States
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Millville, New Jersey, United States
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Sewell, New Jersey, United States
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Toms River, New Jersey, United States
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Albuquerque, New Mexico, United States
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Buffalo, New York, United States
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Buffalo, New York, United States
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Cortland, New York, United States
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Horseheads, New York, United States
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Massapequa, New York, United States
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The Bronx, New York, United States
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High Point, North Carolina, United States
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Kings Mountain, North Carolina, United States
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New Bern, North Carolina, United States
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Wilmington, North Carolina, United States
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Winston-Salem, North Carolina, United States
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Columbus, Ohio, United States
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Oklahoma City, Oklahoma, United States
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DuBois, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Rock Hill, South Carolina, United States
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Franklin, Tennessee, United States
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Johnson City, Tennessee, United States
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Dallas, Texas, United States
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Forney, Texas, United States
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Fort Worth, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Humble, Texas, United States
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Kerrville, Texas, United States
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Mansfield, Texas, United States
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Clearfield, Utah, United States
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Morgantown, West Virginia, United States
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Cudahy, Wisconsin, United States
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Milwaukee, Wisconsin, United States
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Bragança Paulista, Brazil
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Brasília, Brazil
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Campinas, Brazil
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Chapecó, Brazil
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Curitiba, Brazil
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Jaú, Brazil
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Mossoró, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Salvador, Brazil
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São José do Rio Preto, Brazil
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Vitória, Brazil
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Calgary, Alberta, Canada
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Vancouver, British Columbia, Canada
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Ajax, Ontario, Canada
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Burlington, Ontario, Canada
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Scarborough Village, Ontario, Canada
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Toronto, Ontario, Canada
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Winchester, Ontario, Canada
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Windsor, Ontario, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Québec, Quebec, Canada
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Québec, Quebec, Canada