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Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
Sponsor: Eli Lilly and Company
Summary
The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if olomorasib in combination with durvalumab is more effective than the durvalumab and placebo combination in part B in participants with unresectable KRAS G12C-mutant non-small cell lung cancer. The study may last up to 3 years for each participant.
Official title: A Phase 3, Multicenter, Double-Blind, Placebo-controlled Study Assessing the Efficacy and Safety of Olomorasib in Combination With Standard of Care Immunotherapy in Participants With Resected or Unresectable KRAS G12C-Mutant, Non-Small Cell Lung Cancer - SUNRAY-02
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
700
Start Date
2025-03-27
Completion Date
2032-02
Last Updated
2026-10-07
Healthy Volunteers
No
Conditions
Interventions
Olomorasib
Administered orally.
Pembrolizumab
Administered intravenously (IV).
Durvalumab
Administered IV.
Placebo
Administered orally.
Locations (366)
Clearview Cancer Institute
Huntsville, Alabama, United States
Infirmary Cancer Care
Mobile, Alabama, United States
City of Hope, Phoenix
Phoenix, Arizona, United States
The University of Arizona Cancer Center - North Campus
Tucson, Arizona, United States
Highlands Oncology Group
Springdale, Arkansas, United States
UCLA Hematology/Oncology - Santa Monica
Los Angeles, California, United States
Profound Research LLC
Oceanside, California, United States
University of California, Irvine (UCI) Health - UC Irvine Medical Center
Orange, California, United States
Stanford Cancer Center
Palo Alto, California, United States
Kaiser Permanente San Diego Mission Road
San Diego, California, United States
BASS Cancer Center
Walnut Creek, California, United States
Hartford Hospital (HH)
Hartford, Connecticut, United States
Sibley Memorial Hospital
Washington D.C., District of Columbia, United States
Boca Raton Regional Hospital
Boca Raton, Florida, United States
Florida Cancer Specialists - South
Fort Myers, Florida, United States
Miami Cancer Institute at Baptist Health, Inc.
Miami, Florida, United States
Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala
Ocala, Florida, United States
Florida Cancer Specialists North
St. Petersburg, Florida, United States
Comprehensive Hematology Oncology
St. Petersburg, Florida, United States
Moffitt Cancer Center
Tampa, Florida, United States
Florida Cancer Specialists East
West Palm Beach, Florida, United States
University Cancer & Blood Center, LLC
Athens, Georgia, United States
Winship Cancer Institute
Atlanta, Georgia, United States
City of Hope National Medical Center, Atlanta Cancer Center
Newnan, Georgia, United States
City of Hope, Chicago
Chicago, Illinois, United States
Northwestern Memorial Hospital
Chicago, Illinois, United States
University of Illinois at Chicago
Chicago, Illinois, United States
University of Chicago Medical Center
Chicago, Illinois, United States
Captain James A. Lovell Federal Health Care Center
North Chicago, Illinois, United States
OSF Saint Francis Medical Center
Peoria, Illinois, United States
Springfield Clinic Main Campus
Springfield, Illinois, United States
Parkview Research Center at Parkview Regional Medical Center
Fort Wayne, Indiana, United States
Franciscan Health
Indianapolis, Indiana, United States
Baptist Health Lexington
Lexington, Kentucky, United States
Baptist Health Hamburg
Lexington, Kentucky, United States
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, United States
Ochsner Health Ochsner Cancer Center - Baton Rouge
Baton Rouge, Louisiana, United States
Ochsner Clinic Foundation
New Orleans, Louisiana, United States
New England Cancer Specialists
Westbrook, Maine, United States
University of Maryland
Baltimore, Maryland, United States
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States
James M Stockman Cancer Institute
Frederick, Maryland, United States
Lahey Hospital & Medical Center
Burlington, Massachusetts, United States
Reliant Medical Group
Worcester, Massachusetts, United States
Karmanos Cancer Institute
Detroit, Michigan, United States
Missouri Baptist Medical Center
St Louis, Missouri, United States
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States
Jefferson Health - Cherry Hill
Cherry Hill, New Jersey, United States
Sidney Kimmel Cancer Center - Washington Township
Sewell, New Jersey, United States
Columbia University Irving Medical Center
New York, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Northport VA Medical Center
Northport, New York, United States
WakeMed Raleigh Campus
Raleigh, North Carolina, United States
Aultman Hospital
Canton, Ohio, United States
Miami Valley Hospital South
Centerville, Ohio, United States
Fairview Hospital
Cleveland, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T
Columbus, Ohio, United States
OhioHealth Riverside Methodist Hospital
Columbus, Ohio, United States
Cleveland Clinic - Hillcrest Hospital
Mayfield Heights, Ohio, United States
Providence Portland Medical Center
Portland, Oregon, United States
Providence St. Vincent Medical Center
Portland, Oregon, United States
Kaiser Permanente Interstate Medical Office Central
Portland, Oregon, United States
Oregon Health and Science University
Portland, Oregon, United States
Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office
Philadelphia, Pennsylvania, United States
Jefferson Hospital Northeast
Philadelphia, Pennsylvania, United States
AHN Allegheny General Hospital
Pittsburgh, Pennsylvania, United States
Medical University of South Carolina
Charleston, South Carolina, United States
Lexington Medical Center
West Columbia, South Carolina, United States
Avera Cancer Institute- Research
Sioux Falls, South Dakota, United States
Tennessee Oncology Chattanooga
Chattanooga, Tennessee, United States
University of Tennessee Medical Center
Knoxville, Tennessee, United States
Sarah Cannon Research Institute
Nashville, Tennessee, United States
SCRI Oncology Partners
Nashville, Tennessee, United States
Tennessee Oncology
Nashville, Tennessee, United States
The Center for Cancer and Blood Disorders
Fort Worth, Texas, United States
Kelsey-Seybold Clinic
Houston, Texas, United States
Houston Methodist Hospital
Houston, Texas, United States
University of Texas MD Anderson Cancer Center
Houston, Texas, United States
USO - Texas Oncology - San Antonio
San Antonio, Texas, United States
USO - Texas Oncology Gulf Coast
Sugar Land, Texas, United States
USO - US Oncology Research Network
The Woodlands, Texas, United States
The University of Vermont Medical Center Inc.
Burlington, Vermont, United States
University of Virginia Health System
Charlottesville, Virginia, United States
VCU Health Adult Outpatient Pavillion
Richmond, Virginia, United States
Swedish Cancer Institute - Edmonds
Edmonds, Washington, United States
Swedish Medical Center
Seattle, Washington, United States
Cancer Care Northwest - Vercler
Spokane Valley, Washington, United States
Northwest Cancer Specialists PC
Vancouver, Washington, United States
University Hospital and UW Health Clinics
Madison, Wisconsin, United States
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Icon Cancer Centre Wesley
Auchenflower, Australia
Sunshine Coast University Hospital
Birtinya, Australia
Austin Health
Heidelberg, Australia
ICON Cancer Centre - Kurralta Park
Kurralta Park, Australia
Tamworth Hospital
North Tamworth, Australia
Sir Charles Gairdner Hospital
Perth, Australia
Goulburn Valley Health
Shepparton, Australia
Latrobe Regional Health
Traralgon, Australia
Medizinische Universität Graz
Graz, Austria