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Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
Sponsor: AstraZeneca
Summary
This is a Phase III, randomised, open-label, sponsor-blinded, 3-arm, multicentre, global study assessing the efficacy and safety of rilvegostomig in combination with bevacizumab with or without tremelimumab compared to atezolizumab in combination with bevacizumab. This study will be conducted in participants with advanced HCC who are not amenable to curative therapy or locoregional therapy
Official title: A Phase III, Randomised, Open-label, Sponsor-blinded, Multicentre Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1220
Start Date
2025-05-06
Completion Date
2030-03-15
Last Updated
2026-10-13
Healthy Volunteers
No
Conditions
Interventions
Tremelimumab
IV therapy
Rilvegostomig
IV therapy
Bevacizumab
IV therapy
Atezolizumab
IV therapy
Locations (226)
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Phoenix, Arizona, United States
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Tucson, Arizona, United States
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Los Angeles, California, United States
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Palo Alto, California, United States
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Denver, Colorado, United States
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New Haven, Connecticut, United States
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Newark, Delaware, United States
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Jacksonville, Florida, United States
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Orlando, Florida, United States
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Atlanta, Georgia, United States
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Atlanta, Georgia, United States
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Honolulu, Hawaii, United States
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Chicago, Illinois, United States
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Indianapolis, Indiana, United States
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Shreveport, Louisiana, United States
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Detroit, Michigan, United States
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Grand Rapids, Michigan, United States
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Rochester, Minnesota, United States
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St Louis, Missouri, United States
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New Brunswick, New Jersey, United States
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New York, New York, United States
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New York, New York, United States
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New York, New York, United States
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Cleveland, Ohio, United States
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Oklahoma City, Oklahoma, United States
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Philadelphia, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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Amarillo, Texas, United States
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Austin, Texas, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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San Antonio, Texas, United States
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Tyler, Texas, United States
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Arlington, Virginia, United States
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Salem, Virginia, United States
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Seattle, Washington, United States
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Milwaukee, Wisconsin, United States
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Camperdown, Australia
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Clayton, Australia
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Heidelberg, Australia
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Randwick, Australia
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South Brisbane, Australia
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Barretos, Brazil
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Porto Alegre, Brazil
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Santa Maria, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Vitória, Brazil
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Edmonton, Alberta, Canada
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Halifax, Nova Scotia, Canada
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Barrie, Ontario, Canada
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Brampton, Ontario, Canada
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Cambridge, Ontario, Canada
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Ottawa, Ontario, Canada
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Toronto, Ontario, Canada
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Montreal, Quebec, Canada
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Québec, Quebec, Canada
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Beijing, China
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Beijing, China
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Beijing, China
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Changchun, China
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Changsha, China
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Chengdu, China
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Chifeng, China
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Chongqing, China
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Deyang, China
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Fuzhou, China
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Guangzhou, China
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Guangzhou, China
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Guiyang, China
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Harbin, China
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Hefei, China
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Hohhot, China
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Kunming, China
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Linyi, China
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Lishui, China
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Luoyang, China
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Nanchang, China
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Nanchang, China
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Nanjing, China
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Nanning, China
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Nantong, China
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Neijiang, China
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Shandong, China
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Shanghai, China
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Shenyang, China
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Shenyang, China
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Weifang, China
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Wenzhou, China
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Wuhan, China
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Xi'an, China
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Zhengzhou, China
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Clichy, France
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Lille, France
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Lyon, France
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Montpellier, France
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Nantes, France
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Nice, France
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Pessac, France
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Rennes, France